Gap junctions are multimolecular complexes that link neighbouring cells and provide channels that allow small molecules to pass between them. They comprise members of the connexin family, mutations in which are associated with several disorders, including inherited forms of deafness, skin disease and cataracts. Recent work has provided significant insight into the structure and functions of gap junctions. In Cell Science at a Glance (see p. 4479 + poster), Bruce Nicholson surveys what we now know about gap junctions, their components and the phenotypes associated with connexin dysfunction.
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