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Leukocyte migration from a fish eye's view
Qing Deng, Anna Huttenlocher


In the last five years, the zebrafish (Danio rerio) has rapidly gained popularity as a model system for studying leukocyte migration and trafficking in vivo. The optical clarity of zebrafish embryos, as well as the potential for genetic manipulation and the development of tools for live imaging, have provided new insight into how leukocytes migrate in response to directional cues in live animals. This Commentary discusses recent progress in our understanding of how leukocytes migrate in vivo, including the role of intracellular signaling through phosphatidylinositol 3-kinase (PI3K) in both random and directed migration. The importance of leukocyte reverse migration in the resolution of inflammation will also be discussed. Finally, we will highlight how zebrafish models have helped to provide new insight into leukocyte migration and the way in which migration is altered in disease.


  • ‡Present address: 4205 Microbial Sciences Building, 1550 Linden Drive, Madison, WI 53706, USA

  • Funding

    This work was supported by National Institutes of Health Grants [grant number GM074827 to A.H.]. Deposited in PMC for release after 12 months.

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