Cover: a polyp of the cnidarian Hydractinia echinata showing acetylated tubulin (green), F-actin (red) and DNA (blue). Manipulating the expression of Nanos2 interferes with the fate of early neural progenitors, disrupting the balance between two distinct cell lineages in the nervous system of the animal. Image by R. C. Millane. See article by J. Kanska and U. Frank (pp. 3192–3203).