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Table of Contents

October 1, 2015; 128(19)






  • Collagen VI at a glance
    Matilde Cescon, Francesca Gattazzo, Peiwen Chen, Paolo Bonaldo

    Summary: Collagen VI is a remarkable component of the extracellular matrix, and studies have highlighted a crucial role for this protein in a wide range of tissues under physiological and pathological conditions.



  • PDGFRβ and oncogenic mutant PDGFRα D842V promote disassembly of primary cilia through a PLCγ- and AURKA-dependent mechanism
    Brian S. Nielsen, Raj R. Malinda, Fabian M. Schmid, Stine F. Pedersen, Søren T. Christensen, Lotte B. Pedersen

    Summary: Growth-factor-dependent primary cilia disassembly occurs at the G0–G1 transition. PDGFR-mediated PLCγ signaling induces deciliation by activating intracellular Ca2+ release and, thereby, AURKA.

  • Cytoophidium assembly reflects upregulation of IMPDH activity
    Chia-Chun Chang, Wei-Cheng Lin, Li-Mei Pai, Hsuan-Shu Lee, Shinn-Chih Wu, Shih-Torng Ding, Ji-Long Liu, Li-Ying Sung

    Summary: The formation of IMPDH cytoophidia reflects upregulation of purine nucleotide synthesis, suggesting that the IMPDH cytoophidium plays a distinct role from that of the CTPS cytoophidium in controlling nucleotide homeostasis.


  • RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells
    Luke H. Hoeppner, Sutapa Sinha, Ying Wang, Resham Bhattacharya, Shamit Dutta, Xun Gong, Victoria M. Bedell, Sandip Suresh, Changzoon Chun, Ramani Ramchandran, Stephen C. Ekker, Debabrata Mukhopadhyay

    Highlighted Article: RhoC maintains vascular homeostasis in endothelial cells yet is dispensable for vascular development. Inhibition of RhoC represents an attractive therapeutic approach to prevent cancer metastasis.

  • Genetic evidence for a microtubule-capture mechanism during polarised growth of Aspergillus nidulans
    Raphael Manck, Yuji Ishitsuka, Saturnino Herrero, Norio Takeshita, G. Ulrich Nienhaus, Reinhard Fischer

    Summary: Microtubule plus ends are guided in the tip of growing fungal hyphae along actin cables and converge in one point.

  • Tetraspanin-3 is an organizer of the multi-subunit Nogo-A signaling complex
    Nina K. Thiede-Stan, Björn Tews, David Albrecht, Zorica Ristic, Helge Ewers, Martin E. Schwab

    Highlighted Article: Tetraspanin-3 is an organizer of the multi-subunit Nogo-A signaling complex. It acts in a protein complex with Nogo-A-Δ20 and S1PR2, and is required during Nogo-A-Δ20-mediated cell spreading and inhibition of neurite outgrowth.

  • Low levels of endogenous or X-ray-induced DNA double-strand breaks activate apoptosis in adult neural stem cells
    Lara Barazzuol, Nicole Rickett, Limei Ju, Penny A. Jeggo

    Summary: This study shows that endogenous and radiation-induced DNA damage sensitively activates apoptosis in the adult sub-ventricular zone (SVZ). Developmentally regulated apoptosis is shown in the neonatal SVZ.

  • Altering lamina assembly reveals lamina-dependent and -independent functions for A-type lamins
    Monika Zwerger, Heidi Roschitzki-Voser, Reto Zbinden, Celine Denais, Harald Herrmann, Jan Lammerding, Markus G. Grütter, Ohad Medalia

    Highlighted Article: By using DARPin technology, we inhibit lamin A assembly in vitro and integration of lamin A/C into the native lamina to identify lamina-dependent and -independent functions for A-type lamins.

  • FoxO1 inhibits transcription and membrane trafficking of epithelial Na+ channel
    Yachen Shen, Weifeng Xu, Hui You, Dongming Su, Jing Xing, Min Li, Lei Li, Xiubin Liang

    Summary: FoxO1 is a key negative regulatory factor in the insulin-dependent control of ENaC expression, and FoxO1 phosphorylation promotes ENaC membrane trafficking by binding to 14-3-3ε in epithelium.

  • MyoD transcription factor induces myogenesis by inhibiting Twist-1 through miR-206
    Demetris Koutalianos, Andrie Koutsoulidou, Nikilaos P. Mastroyiannopoulos, Denis Furling, Leonidas A. Phylactou

    Highlighted Article: We identify a mechanism of myogenesis in which MyoD and miR-206 downregulate the expression of Twist-1. This pathway might also play an important role in muscle disease.

  • Yeast Pmp3p has an important role in plasma membrane organization
    Julien De Block, Aleksandra Szopinska, Bérengère Guerriat, Joanna Dodzian, Jennifer Villers, Jean-François Hochstenbach, Pierre Morsomme

    Summary: Yeast PMP3 has strong genetic interactions with the sphingolipid synthesis pathway. Pmp3p controls the plasma membrane composition and may act as a phosphoinositide-regulated stress sensor.

  • Polycomb RING1A- and RING1B-dependent histone H2A monoubiquitylation at pericentromeric regions promotes S-phase progression
    Mónica Bravo, Fabio Nicolini, Katarzyna Starowicz, Sonia Barroso, Carmela Calés, Andrés Aguilera, Miguel Vidal

    Highlighted Article: The polycomb E3 ligases RING1A and RING1B monoubiquitylate histone H2A in pericentromeric DNA to promote replication, and hence histone H2A has a function beyond transcription.

  • The fission yeast cytokinetic contractile ring regulates septum shape and closure
    Sathish Thiyagarajan, Emilia Laura Munteanu, Rajesh Arasada, Thomas D. Pollard, Ben O'Shaughnessy

    Summary: During cytokinesis in fission yeast the tension of the actomyosin contractile ring regulates septum closure by suppressing roughness of the septum edge, while septum growth sets the constriction rate.


From Development