‘... wow!’ – life made bicycle wheels!

Manuel Théry is the Guest Editor for the 2019 Reconstituting Cell Biology Special Issue. He runs the ‘CytoMorphoLab’ together with Laurent Blanchoin, directing the Paris branch at the Hôpital Saint Louis. Manuel investigates the (self-)assembly of the cytoskeleton and how this orchestrates cell geometry and mechanical information in the cell.

Cell Science at a Glance - Centriole assembly

In this article and poster, Pierre Gönczy and Georgios Hatzopoulos outline the initial steps leading to centriole assembly and highlight some of the important functions for the centriole organelle in cells.

This Review from Kristina Ganzinger and Petra Schwille focusses on how bottom-up reconstitution has furthered our understanding of cell biology, and how it will continue to do so as researchers reconstitute increasingly complex biomolecular processes.

Understanding of the mechanisms involved in T cell receptor activation has been greatly advanced by reconstitution systems. Katharina Gaus and team review how clustering of the T cell receptor impacts on signal transduction in T cells and how reconstitution systems have contributed to this knowledge.