Table of Contents
IN THIS ISSUE
CELL SCIENCE AT A GLANCE
- Cancer metabolism at a glance
Summary: This article indicates metabolic pathways essential for cancer growth and survival, with an emphasis on anticancer therapies that are associated with such metabolic vulnerabilities.
- Collective migration and cell jamming in asthma, cancer and development
Summary: In development and wound repair, cellular unjamming promotes cooperative cellular migration, whereas in cancer invasion, asthma and aberrant wound repair, it unleashes remarkably asocial cellular misbehavior.
- Efferocytosis and extrusion of leukocytes determine the progression of early mycobacterial pathogenesis
Highlighted Article: Mycobacterial infection in zebrafish larvae was explored using a combination of light and electron microscopy. Macrophage burst events resulted in a progression of infection, whereas epithelium-mediated extrusion of infected immune cells abated infection.
- The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin
Summary: We describe a new role for RNF146 and tankyrase in maintaining the Crumbs complex and apical-basal integrity in epithelial cells through regulation of ADP-ribosylation and ubiquitin-dependent degradation of the angiomotin AmotL2.
- Persistent nuclear actin filaments inhibit transcription by RNA polymerase II
Highlighted Article: Depletion of actin in the nucleus by polymerization into stable nuclear actin filaments inhibits the actin–polymerase-II interaction, resulting in impaired RNA polymerase II activity, localization, and gene recruitment.
- Drosophila Kette coordinates myoblast junction dissolution and the ratio of Scar-to-WASp during myoblast fusion
Summary: The Drosophila protein Kette is essential for myoblast fusion. It controls the dissolution of electron-dense plaques and the ratio of Scar and WASp proteins in fusion-competent myoblasts during fusion pore formation.
- Bradykinin promotes neuron-generating division of neural progenitor cells through ERK activation
Highlighted Article: Bradykinin induces neuron-generating division in vitro and in vivo, lengthening the G1 phase of the cell cycle and TIS21 expression. Neurogenesis through kinin-B2 receptor signaling was dependent on sustained ERK activation.
- Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity
Summary: Tensin 3 regulates podosome patterning in osteoclasts and bone resorption. Here, we show that tensin 3 is a partner of the Rac exchange factor Dock5 that stimulates its activity.
- Local Ras activation, PTEN pattern, and global actin flow in the chemotactic responses of oversized cells
Highlighted Article: The chemotactic response system of Dictyostelium cells can accommodate larger cells, in a way that involves asymmetric Ras activation in turning protrusions, unconventional PTEN patterns and tail-directed actin flow during the establishment of polarity.
- Proplatelet formation is selectively inhibited by collagen type I through Syk-independent GPVI signaling
Summary: Binding of collagen type I to GPVI on megakaryocytes inhibits premature proplatelet formation by a Syk-independent pathway that is distinct from GPVI signaling in platelets.
- The membrane trafficking and functionality of the K+-Cl− co-transporter KCC2 is regulated by TGF-β2
Summary: TGF-β2 promotes K+-Cl−-co-transporter KCC2 trafficking and functional activation in hippocampal neurons through a TGF-β2, CREB and Rab11b signaling pathway.
- Kinesin-1 sorting in axons controls the differential retraction of arbor terminals
Summary: Axonal transport of kinesin-1 and microtubule dynamics are differentially regulated between terminals in a single axon, and contribute to shaping the axonal arbor by differentially regulating retraction of terminals.
TOOLS AND TECHNIQUES
- Visualizing red blood cell sickling and the effects of inhibition of sphingosine kinase 1 using soft X-ray tomography
Highlighted Article: Soft X-ray cryotomography revealed an inverse relationship between sickle RBC volume and number of protrusions upon sickling. Subtomogram analysis showed beneficial effects with Sphk1 inhibitor treatment.
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