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Table of Contents

SPECIAL ISSUE: 3D Cell Biology
Guest editor: Andrew Ewald
January 1, 2017; 130 (1)

EDITORIAL

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    3D cell biology – the expanding frontier
    Andrew J. Ewald (Editor)
    J Cell Sci 2017 130: 1 doi: 10.1242/jcs.200543

FOREWORD

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    Goodbye flat biology – time for the 3rd and the 4th dimensions
    Mina J. Bissell
    J Cell Sci 2017 130: 3-5; doi: 10.1242/jcs.200550

CELL SCIENTISTS TO WATCH

  • You have accessSubscription required
    Interview with the Guest Editor – Andrew Ewald
    J Cell Sci 2017 130: 7-9; doi: 10.1242/jcs.199976
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    Cell scientist to watch – Madeline Lancaster
    J Cell Sci 2017 130: 11-13; doi: 10.1242/jcs.199984

CELL SCIENCE AT A GLANCE

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    Embryo–epithelium interactions during implantation at a glance
    John D. Aplin, Peter T. Ruane
    J Cell Sci 2017 130: 15-22; doi: 10.1242/jcs.175943

    Summary: At implantation, attachment of embryonic trophectoderm alters epithelial polarity and invasive trophoblast differentiates. We describe cellular and molecular events during the epithelial phase in rodent and human.

COMMENTARIES

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    Seeing is believing – multi-scale spatio-temporal imaging towards in vivo cell biology
    Gautier Follain, Luc Mercier, Naël Osmani, Sébastien Harlepp, Jacky G. Goetz
    J Cell Sci 2017 130: 23-38; doi: 10.1242/jcs.189001

    Summary: This Commentary provides an overview of the imaging technologies currently available for performing cell biology in vivo.

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    Microtubules in 3D cell motility
    Benjamin P. Bouchet, Anna Akhmanova
    J Cell Sci 2017 130: 39-50; doi: 10.1242/jcs.189431

    Summary: We discuss microtubule functions that control cell shape and motility in 3D matrices, and the differences of microtubule involvement in cell morphogenesis and motility between 2D and 3D environments.

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    How cells respond to environmental cues – insights from bio-functionalized substrates
    Verena Ruprecht, Pascale Monzo, Andrea Ravasio, Zhang Yue, Ekta Makhija, Pierre Olivier Strale, Nils Gauthier, G. V. Shivashankar, Vincent Studer, Corinne Albiges-Rizo, Virgile Viasnoff
    J Cell Sci 2017 130: 51-61; doi: 10.1242/jcs.196162

    Summary: Cells are sensitive to some biophysical aspects of the environment. This Commentary reviews how bio-functionalized substrates can be used to analyze how cells sense and interact with their environment.

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    3D culture models of tissues under tension
    Jeroen Eyckmans, Christopher S. Chen
    J Cell Sci 2017 130: 63-70; doi: 10.1242/jcs.198630

    Summary: Engineered 3D cultures of cells have mainly focused on epithelial tissues. In this Commentary, advances in engineered microtissue systems to model fibrous tissues under mechanical load are discussed.

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    Tissue mechanics regulate brain development, homeostasis and disease
    J. Matthew Barnes, Laralynne Przybyla, Valerie M. Weaver
    J Cell Sci 2017 130: 71-82; doi: 10.1242/jcs.191742

    Summary: In this Commentary, the roles of cell and tissue mechanics in brain development, homeostasis and neural degeneration, as well as in brain cancer, are reviewed.

SHORT REPORTS

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    3D electron tomography of brain tissue unveils distinct Golgi structures that sequester cytoplasmic contents in neurons
    Maria Rosario Fernandez-Fernandez, Desire Ruiz-Garcia, Eva Martin-Solana, Francisco Javier Chichon, Jose L. Carrascosa, Jose-Jesus Fernandez
    J Cell Sci 2017 130: 83-89; doi: 10.1242/jcs.188060

    Summary: The power of new 3D imaging technologies, and optimal preservation of tissue samples, has helped to identify previously uncharacterized Golgi structures that sequester cytoplasmic material in neurons.

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    Epidermal growth factor suppresses intestinal epithelial cell shedding through a MAPK-dependent pathway
    Jennifer C. Miguel, Adrienne A. Maxwell, Jonathan J. Hsieh, Lukas C. Harnisch, Denise Al Alam, D. Brent Polk, Ching-Ling Lien, Alastair J. M. Watson, Mark R. Frey
    J Cell Sci 2017 130: 90-96; doi: 10.1242/jcs.182584

    Summary: Regulated cell shedding is important for epithelial tissue turnover, but the signals controlling it are poorly understood. This study shows that epidermal growth factor suppresses shedding through MAPK activation.

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    Myosin II governs collective cell migration behaviour downstream of guidance receptor signalling
    Anne Combedazou, Valérie Choesmel-Cadamuro, Guillaume Gay, Jiaying Liu, Loïc Dupré, Damien Ramel, Xiaobo Wang
    J Cell Sci 2017 130: 97-103; doi: 10.1242/jcs.179952

    Summary: Non-muscle myosin II (NMII) is the key regulator for the control of border cell behaviours. Positively regulated by EGFR, NMII induces the switch of border cell movement from linear to rotational.

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    A basal cell defect promotes budding of prostatic intraepithelial neoplasia
    Mengdie Wang, Raymond B. Nagle, Beatrice S. Knudsen, Gregory C. Rogers, Anne E. Cress
    J Cell Sci 2017 130: 104-110; doi: 10.1242/jcs.188177

    Summary: A dynamic 3D model of HG-PIN was created using immortalized human prostate epithelial cells with a basal cell defect. The model can be used to test molecular events that disrupt cancer progression.

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    EphA2 proteomics in human keratinocytes reveals a novel association with afadin and epidermal tight junctions
    Bethany E. Perez White, Rosa Ventrella, Nihal Kaplan, Calvin J. Cable, Paul M. Thomas, Spiro Getsios
    J Cell Sci 2017 130: 111-118; doi: 10.1242/jcs.188169

    Summary: EphA2 was used as a prototypical receptor tyrosine kinase to map a signaling protein interaction network in 2D and 3D stratified epithelial tissue cultures composed of primary human skin cells.

RESEARCH ARTICLES

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    Cell-cycle-dependent TGFβ–BMP antagonism regulates neural tube closure by modulating tight junctions
    Smita Amarnath, Seema Agarwala
    J Cell Sci 2017 130: 119-131; doi: 10.1242/jcs.179192

    Summary: By modulating tight junctions, cell-cycle-dependent interactions among the TGFβ, BMP and apicobasal polarity pathways create a dynamic neural epithelium that can be shaped to form a closed neural tube.

  • Open Access
    Morphological process of podocyte development revealed by block-face scanning electron microscopy
    Koichiro Ichimura, Soichiro Kakuta, Yuto Kawasaki, Takayuki Miyaki, Takahiro Nonami, Naoyuki Miyazaki, Tomoyo Nakao, Sakiko Enomoto, Shigeo Arai, Masato Koike, Kazuyoshi Murata, Tatsuo Sakai
    J Cell Sci 2017 130: 132-142; doi: 10.1242/jcs.187815

    Summary: The unique 3D architecture of podocytes is difficult to visualize by conventional SEM. In this study, the developmental process of podocytes was investigated by block-face SEM imaging.

  • Open Access
    Cell polarity defines three distinct domains in pancreatic β-cells
    Wan J. Gan, Michael Zavortink, Christine Ludick, Rachel Templin, Robyn Webb, Richard Webb, Wei Ma, Philip Poronnik, Robert G. Parton, Herbert Y. Gaisano, Annette M. Shewan, Peter Thorn
    J Cell Sci 2017 130: 143-151; doi: 10.1242/jcs.185116

    Summary: 3D imaging methods identify three structural and functional domains within β-cells in islets: apical, lateral and basal.

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    Applied stretch initiates directional invasion through the action of Rap1 GTPase as a tension sensor
    Spencer A. Freeman, Sonja Christian, Pamela Austin, Irene Iu, Marcia L. Graves, Lin Huang, Shuo Tang, Daniel Coombs, Michael R. Gold, Calvin D. Roskelley
    J Cell Sci 2017 130: 152-163; doi: 10.1242/jcs.180612

    Summary: Tension applied through 3D matrices directs invasion of tumor cells along the tensional axis. Rap1 senses the tension and polarizes the cytoskeletal and subsequent adhesion remodeling.

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    The cytostome–cytopharynx complex of Trypanosoma cruzi epimastigotes disassembles during cell division
    Carolina de L. Alcantara, Juliana C. Vidal, Wanderley de Souza, Narcisa L. Cunha-e-Silva
    J Cell Sci 2017 130: 164-176; doi: 10.1242/jcs.187419

    Summary: As shown by focused ion beam scanning electron microscopy, the cytostome–cytopharynx complex of T. cruzi epimastigotes disassembles in mitosis, to assemble again in each daughter cell at the end of cell division.

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    Deep nuclear invaginations are linked to cytoskeletal filaments – integrated bioimaging of epithelial cells in 3D culture
    Danielle M. Jorgens, Jamie L. Inman, Michal Wojcik, Claire Robertson, Hildur Palsdottir, Wen-Ting Tsai, Haina Huang, Alexandre Bruni-Cardoso, Claudia S. López, Mina J. Bissell, Ke Xu, Manfred Auer
    J Cell Sci 2017 130: 177-189; doi: 10.1242/jcs.190967

    Summary: Fluorescence and electron microscopy analysis of HMECs grown in 3D reveals deep nuclear invaginations and tunnels that wrap around cytoskeleton cables, thus connecting the microenvironment to the nucleus.

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    Increased ROS production in non-polarized mammary epithelial cells induces monocyte infiltration in 3D culture
    Linzhang Li, Jie Chen, Gaofeng Xiong, Daret K. St Clair, Wei Xu, Ren Xu
    J Cell Sci 2017 130: 190-202; doi: 10.1242/jcs.186031

    Summary: Increased ROS levels contribute to the disruption of polarized acinar structures and induce monocyte recruitment through induction of the NF-κB pathway and cytokine expression.

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    Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT–mTOR–S6K signaling and drug responses
    Angelika Riedl, Michaela Schlederer, Karoline Pudelko, Mira Stadler, Stefanie Walter, Daniela Unterleuthner, Christine Unger, Nina Kramer, Markus Hengstschläger, Lukas Kenner, Dagmar Pfeiffer, Georg Krupitza, Helmut Dolznig
    J Cell Sci 2017 130: 203-218; doi: 10.1242/jcs.188102

    Summary: Colon cancer spheroids have decreased AKT–mTOR–S6K activity, spatial differences in signaling intensity as well as differing responses upon inhibition of the AKT–mTOR–S6K or MAPK axes in comparison with 2D cultures.

  • Open Access
    Pax8 controls thyroid follicular polarity through cadherin-16
    Petrina Koumarianou, Gonzalo Goméz-López, Pilar Santisteban
    J Cell Sci 2017 130: 219-231; doi: 10.1242/jcs.184291

    Summary: Using a 3D culture model of thyroid morphogenesis, it is revealed that thyroid follicular cell polarity depends on the Pax8 transcription factor and is linked to the β1-integrin–laminin pathway through Cdh16.

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    Ultrasound patterning technologies for studying vascular morphogenesis in 3D
    Eric S. Comeau, Denise C. Hocking, Diane Dalecki
    J Cell Sci 2017 130: 232-242; doi: 10.1242/jcs.188151

    Summary: Acoustic patterning techniques provide a non-invasive method to direct the spatial organization of endothelial cells within 3D collagen hydrogels and, in turn, control microvessel morphogenesis.

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    ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture
    Matthew A. Odenwald, Wangsun Choi, Aaron Buckley, Nitesh Shashikanth, Nora E. Joseph, Yitang Wang, Michael H. Warren, Mary M. Buschmann, Roman Pavlyuk, Jeffrey Hildebrand, Ben Margolis, Alan S. Fanning, Jerrold R. Turner
    J Cell Sci 2017 130: 243-259; doi: 10.1242/jcs.188185

    Summary: ZO-1–occludin interactions provide signals that are required for polarization and 3D morphogenesis; these results elucidate the contributions of tight junction structural proteins to 3D epithelial organization.

TOOLS AND TECHNIQUES

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    Three-dimensional imaging of the intracellular assembly of a functional viral RNA replicase complex
    Isabel Fernández de Castro, José J. Fernández, Daniel Barajas, Peter D. Nagy, Cristina Risco
    J Cell Sci 2017 130: 260-268; doi: 10.1242/jcs.181586

    Summary: Study of virus and cell functions by molecular mapping and three-dimensional imaging of a viral replication complex using a clonable tag for electron microscopy analysis.

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    A toolbox to study epidermal cell types in zebrafish
    George T. Eisenhoffer, Gloria Slattum, Oscar E. Ruiz, Hideo Otsuna, Chase D. Bryan, Justin Lopez, Daniel S. Wagner, Joshua L. Bonkowsky, Chi-Bin Chien, Richard I. Dorsky, Jody Rosenblatt
    J Cell Sci 2017 130: 269-277; doi: 10.1242/jcs.184341

    Summary: Here we introduce tools to easily track, ablate or monitor subsets of cells in the developing zebrafish epidermis, providing an excellent in vivo model system to study a living epithelium.

  • Open Access
    3D correlative light and electron microscopy of cultured cells using serial blockface scanning electron microscopy
    Matthew R. G. Russell, Thomas R. Lerner, Jemima J. Burden, David O. Nkwe, Annegret Pelchen-Matthews, Marie-Charlotte Domart, Joanne Durgan, Anne Weston, Martin L. Jones, Christopher J. Peddie, Raffaella Carzaniga, Oliver Florey, Mark Marsh, Maximiliano G. Gutierrez, Lucy M. Collinson
    J Cell Sci 2017 130: 278-291; doi: 10.1242/jcs.188433

    Summary: A new workflow for 3D correlative light and electron microscopy of cell monolayers, applied to studies of M.-tuberculosis-infected cells, HIV-1-infected cells and entotic cell-in-cell structures.

  • Open Access
    Shear-wave elasticity measurements of three-dimensional cell cultures for mechanobiology
    Po-Ling Kuo, Ching-Che Charng, Po-Chen Wu, Pai-Chi Li
    J Cell Sci 2017 130: 292-302; doi: 10.1242/jcs.186320

    Summary: Use of a non-direct-contact platform for measurement of the spatiotemporal dynamics of matrix elasticity when remodeled by cells cultured in three-dimensional contexts.

ARTICLES OF INTEREST IN OUR OTHER JOURNALS

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      Insights from imaging the implanting embryo and the uterine environment in three dimensions
      Arora Ripla, Fries Adam, Oelerich Karina, Marchuk Kyle, Sabeur Khalida, Giudice Linda C., Laird Diana J.
      J Cell Sci 2017 130: e1.1 doi: 10.1242/jcs.200535
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    RNAi screening identifies a mechanosensitive ROCK-JAK2-STAT3 network central to myofibroblast activation

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