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- Lamins in the nuclear interior − life outside the lamina
Summary: We discuss recent advances in the regulation of the lamina-independent pool of lamins in the nucleoplasm and their emerging functions in chromatin organization, mechanical regulation and disease.
- Molecular mechanisms of kinesin-14 motors in spindle assembly and chromosome segregation
Summary: During cell division, kinesin-14 motors are conserved regulators of spindle assembly and chromosome segregation. We provide a detailed view of their cellular functions in diverse organisms.
SHORT REPORT
- Substrate stiffness-dependent regulation of the SRF−Mkl1 co-activator complex requires the inner nuclear membrane protein Emerin
Summary: The nuclear lamina regulates SRF−Mkl1 activity specifically in cells grown within stiff mechanical environments.
RESEARCH ARTICLES
- Phosphatidylinositol 5-phosphate 4-kinase regulates early endosomal dynamics during clathrin-mediated endocytosis
Highlighted Article: Phosphatidylinositol 5-phosphate 4-kinase regulates early endosomal dynamics and trafficking of plasma membrane receptors through clathrin-mediated endocytosis in Drosophila cells.
- Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging
Summary: Differentiation of nociceptors relies on transcription factors, receptors and neuropeptides. We identify the importance of intracellular signaling, including pathways involved in neuronal memory, for postnatal nociceptor maturation.
- Unique cell biological profiles of retinal disease-causing missense mutations in the polarity protein Crumbs
Highlighted Article: Analysis of Drosophila crb mutations demonstrates that the Crb extracellular region controls protein level and distribution, and suggests that human disease-causing CRB1 missense mutations affect rhodopsin trafficking.
- A Wntless–SEC12 complex on the ER membrane regulates early Wnt secretory vesicle assembly and mature ligand export
Summary: WLS and SEC12 form a stable complex on ER membrane that binds to mature Wnt molecules. We find that several independent protein motifs within WLS are essential for the association of this complex with COPII ER-exiting machinery.
- A dual phenotype of MDA-MB-468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity
Highlighted Article: The cell−matrix adapter protein Tns3 is identified as a determinant of adhesion plasticity in subcultures of cancer cells. Tns3 gene expression constitutes a feedback loop controling cell adhesion and motility.
- The nuclear export factor CRM1 controls juxta-nuclear microtubule-dependent virus transport
Summary: The mechanism through which macromolecular complexes reach the nuclear pores is incompletely understood. We show that the cytoplasmic perinuclear ecology is tuned by CRM1 to control virus transport to the nuclear pore complex.
- TRPV4 mediates the Ca2+ influx required for the interaction between flightless-1 and non-muscle myosin, and collagen remodeling
Highlighted Article: TRPV4 is a Ca2+-permeable channel in the plasma membrane that regulates FliI–NMMIIA interactions, which in turn affects the cell extension formation necessary for the control of collagen remodeling and matrix biology.
- The Kv1-associated molecules TAG-1 and Caspr2 are selectively targeted to the axon initial segment in hippocampal neurons
Summary: The selective distribution of the cell adhesion molecules Caspr2 and TAG-1 might be responsible for positioning of Kv1 channels at the axon initial segment versus along the axon in hippocampal neurons.
ARTICLES OF INTEREST IN OUR OTHER JOURNALS
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Interview with 2019 Hooke medal winner Eugenia Piddini
“The combination of a good question, a powerful model system and a transformative technology is an ideal recipe to start an independent career.”
Eugenia Piddini just received the 2019 Hooke medal, established to recognize an emerging leader in cell biology. She is currently a Professor at the University of Bristol researching the role that cell competition plays in cancer. Eugenia speaks about her research, career choices, how to get the most out of meetings and more.
Catch up with early-career first authors in our First Person interviews. Recently, we spoke to Bertille Bance and Shailaja Seetharaman, Ioanna-Maria Gkotinakou, Norman Groves and Juan Tao.
Sally Wheatley and Dario Altieri highlight our current understanding of the structure, function and cancer implications of survivin biology 21 years on from its initial discovery.
Very little is known about whether, and how, prokaryotes sense and respond to mechanical inputs. Vernita Gordon and Liyun Wang review the emerging field of bacterial mechanosensing and indicate promising directions for future investigation.
Microtubule acetylation and detyrosination are independently regulated and have distinct functions during migration, with microtubule acetylation facilitating the turnover of focal adhesions, show Sandrine Etienne-Manneville and team.
Travelling Fellowships – Expanded understanding of leukaemia treatment
We offer Travelling Fellowships of up to £2,500 to graduate students and post-doctoral researchers wishing to make collaborative visits to other laboratories. The next deadline to apply is 31 May 2019.
Alexander García Ponce used a Travelling Fellowship to go to the Sanquin Blood Bank in The Netherlands. There he investigated how hematopoietic stem cells cross the vascular wall and reach the bone marrow for his PhD project.
Journal of Cell Science is pleased to welcome submissions for an upcoming special issue on 'Cell Biology of the Immune System' edited by Ana-Maria Lennon-Duménil. We invite you to showcase your breakthrough research on all aspects of cell biology as it relates to the immune system. The articles within this issue will receive extensive exposure to a broad audience of cell biologists and immunologists. Submission deadline: 30 June 2019.
Journal news – Fast-track decision process
Do you have a paper previously reviewed by another journal that you’d like to submit to Journal of Cell Science? We will consider your manuscript for fast-track decision making and give you an initial decision within a week. Find out more here.
Amberley Stephens highlights a preprint where the authors use a combination of imaging techniques in live cells to find that HIV-1 sequesters certain lipids to form its own assembly raft using its Gag protein.
Catch up with other recent preLights selected for the cell science community.
Articles of interest in our sister journals
Transient localization of the Arp2/3 complex initiates neuronal dendrite branching in vivo
Tomke Stürner, Anastasia Tatarnikova, Jan Mueller, Barbara Schaffran, Hermann Cuntz, Yun Zhang, Maria Nemethova, Sven Bogdan, Vic Small, Gaia Tavosanis
Development 2019 146: dev171397
Septate junction components control Drosophila hematopoiesis through the Hippo pathway
Rohan J. Khadilkar, Guy Tanentzapf
Development 2019 146: dev166819