Table of Contents
IN THIS ISSUE
STICKY WICKET
CELL SCIENTISTS TO WATCH
MEETING REPORT
COMMENTARIES
- Lamins in the nuclear interior − life outside the lamina
Summary: We discuss recent advances in the regulation of the lamina-independent pool of lamins in the nucleoplasm and their emerging functions in chromatin organization, mechanical regulation and disease.
- Molecular mechanisms of kinesin-14 motors in spindle assembly and chromosome segregation
Summary: During cell division, kinesin-14 motors are conserved regulators of spindle assembly and chromosome segregation. We provide a detailed view of their cellular functions in diverse organisms.
SHORT REPORT
- Substrate stiffness-dependent regulation of the SRF−Mkl1 co-activator complex requires the inner nuclear membrane protein Emerin
Summary: The nuclear lamina regulates SRF−Mkl1 activity specifically in cells grown within stiff mechanical environments.
RESEARCH ARTICLES
- Phosphatidylinositol 5-phosphate 4-kinase regulates early endosomal dynamics during clathrin-mediated endocytosis
Highlighted Article: Phosphatidylinositol 5-phosphate 4-kinase regulates early endosomal dynamics and trafficking of plasma membrane receptors through clathrin-mediated endocytosis in Drosophila cells.
- Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging
Summary: Differentiation of nociceptors relies on transcription factors, receptors and neuropeptides. We identify the importance of intracellular signaling, including pathways involved in neuronal memory, for postnatal nociceptor maturation.
- Unique cell biological profiles of retinal disease-causing missense mutations in the polarity protein Crumbs
Highlighted Article: Analysis of Drosophila crb mutations demonstrates that the Crb extracellular region controls protein level and distribution, and suggests that human disease-causing CRB1 missense mutations affect rhodopsin trafficking.
- A Wntless–SEC12 complex on the ER membrane regulates early Wnt secretory vesicle assembly and mature ligand export
Summary: WLS and SEC12 form a stable complex on ER membrane that binds to mature Wnt molecules. We find that several independent protein motifs within WLS are essential for the association of this complex with COPII ER-exiting machinery.
- A dual phenotype of MDA-MB-468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity
Highlighted Article: The cell−matrix adapter protein Tns3 is identified as a determinant of adhesion plasticity in subcultures of cancer cells. Tns3 gene expression constitutes a feedback loop controling cell adhesion and motility.
- The nuclear export factor CRM1 controls juxta-nuclear microtubule-dependent virus transport
Summary: The mechanism through which macromolecular complexes reach the nuclear pores is incompletely understood. We show that the cytoplasmic perinuclear ecology is tuned by CRM1 to control virus transport to the nuclear pore complex.
- TRPV4 mediates the Ca2+ influx required for the interaction between flightless-1 and non-muscle myosin, and collagen remodeling
Highlighted Article: TRPV4 is a Ca2+-permeable channel in the plasma membrane that regulates FliI–NMMIIA interactions, which in turn affects the cell extension formation necessary for the control of collagen remodeling and matrix biology.
- The Kv1-associated molecules TAG-1 and Caspr2 are selectively targeted to the axon initial segment in hippocampal neurons
Summary: The selective distribution of the cell adhesion molecules Caspr2 and TAG-1 might be responsible for positioning of Kv1 channels at the axon initial segment versus along the axon in hippocampal neurons.
ARTICLES OF INTEREST IN OUR OTHER JOURNALS
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Cell scientist to watch – Kevin Corbett
"[...]the most compelling science emerges when you put together a set of people with different expertise and outlooks on a problem.”
Kevin heads a research group at UC San Diego and the Ludwig Institute for Cancer Research, investigating meiosis and its links to carcinogenesis. He shares his thoughts on fostering successful collaborations and why momentum is key to getting a new lab up and running.
Cell science at a glance – Cellular functions of WASP family proteins at a glance
In this poster and accompanying article, Olga Alekhina, Ezra Burstein and Daniel D. Billadeau provides insight into new functions of WASP family proteins from regulating the biogenesis of autophagosomes to recently identified roles in the nucleus.
Sticky wicket – Peerless II
Mole continues his philosophising on grant applications, this time delving into how to frame your project to capture the imaginations of the review panel.
Have you met our resident insectivore? Read more of his manic musings here.
Meeting report – Emerging concepts in cell organization
In January this year, the 10th Annaberg EMBO workshop was held in a medieval castle in Goldegg am See, Austria. David Teis and Wanda Kukulski report back on this lively exchange of the ideas and new concepts shaping our understanding of how cells are organized and how this organization impacts cellular functions.
Transfer to Biology Open
If your submission to Journal of Cell Science is unsuccessful, did you know you can transfer your paper and any reviews directly to our sister journal, Biology Open? The majority of papers transferred with reviews are accepted for publication. Find out how here.