Table of Contents
IN THIS ISSUE
STICKY WICKET
CELL SCIENTISTS TO WATCH
MEETING REPORT
COMMENTARIES
- Lamins in the nuclear interior − life outside the lamina
Summary: We discuss recent advances in the regulation of the lamina-independent pool of lamins in the nucleoplasm and their emerging functions in chromatin organization, mechanical regulation and disease.
- Molecular mechanisms of kinesin-14 motors in spindle assembly and chromosome segregation
Summary: During cell division, kinesin-14 motors are conserved regulators of spindle assembly and chromosome segregation. We provide a detailed view of their cellular functions in diverse organisms.
SHORT REPORT
- Substrate stiffness-dependent regulation of the SRF−Mkl1 co-activator complex requires the inner nuclear membrane protein Emerin
Summary: The nuclear lamina regulates SRF−Mkl1 activity specifically in cells grown within stiff mechanical environments.
RESEARCH ARTICLES
- Phosphatidylinositol 5-phosphate 4-kinase regulates early endosomal dynamics during clathrin-mediated endocytosis
Highlighted Article: Phosphatidylinositol 5-phosphate 4-kinase regulates early endosomal dynamics and trafficking of plasma membrane receptors through clathrin-mediated endocytosis in Drosophila cells.
- Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging
Summary: Differentiation of nociceptors relies on transcription factors, receptors and neuropeptides. We identify the importance of intracellular signaling, including pathways involved in neuronal memory, for postnatal nociceptor maturation.
- Unique cell biological profiles of retinal disease-causing missense mutations in the polarity protein Crumbs
Highlighted Article: Analysis of Drosophila crb mutations demonstrates that the Crb extracellular region controls protein level and distribution, and suggests that human disease-causing CRB1 missense mutations affect rhodopsin trafficking.
- A Wntless–SEC12 complex on the ER membrane regulates early Wnt secretory vesicle assembly and mature ligand export
Summary: WLS and SEC12 form a stable complex on ER membrane that binds to mature Wnt molecules. We find that several independent protein motifs within WLS are essential for the association of this complex with COPII ER-exiting machinery.
- A dual phenotype of MDA-MB-468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity
Highlighted Article: The cell−matrix adapter protein Tns3 is identified as a determinant of adhesion plasticity in subcultures of cancer cells. Tns3 gene expression constitutes a feedback loop controling cell adhesion and motility.
- The nuclear export factor CRM1 controls juxta-nuclear microtubule-dependent virus transport
Summary: The mechanism through which macromolecular complexes reach the nuclear pores is incompletely understood. We show that the cytoplasmic perinuclear ecology is tuned by CRM1 to control virus transport to the nuclear pore complex.
- TRPV4 mediates the Ca2+ influx required for the interaction between flightless-1 and non-muscle myosin, and collagen remodeling
Highlighted Article: TRPV4 is a Ca2+-permeable channel in the plasma membrane that regulates FliI–NMMIIA interactions, which in turn affects the cell extension formation necessary for the control of collagen remodeling and matrix biology.
- The Kv1-associated molecules TAG-1 and Caspr2 are selectively targeted to the axon initial segment in hippocampal neurons
Summary: The selective distribution of the cell adhesion molecules Caspr2 and TAG-1 might be responsible for positioning of Kv1 channels at the axon initial segment versus along the axon in hippocampal neurons.
ARTICLES OF INTEREST IN OUR OTHER JOURNALS
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Call for papers – Reconstituting cell biology
Deadline for submissions: 1 May 2018
We are now accepting submissions for our upcoming special issue on ‘Reconstituting cell biology’, guest edited by Manuel Théry. Click here for more information.
Opinion – The triple helix of collagens
In a new Opinion article, Billy G. Hudson and colleagues argue that the triple helix is an ancient protein structure of fundamental importance in building the extracellular matrix that enabled animal multicellularity and tissue evolution.
JCS Meeting – Cell dynamics: organelle-cytoskeleton interface
The second in our series of cell dynamics meetings now turns to organelles. This May 2019 meeting in Lisbon, Portugal, aims to bring together scientists studying the interface between organelles and the cytoskeleton at different scales and perspectives using a range of model systems. Find out more and register your interest here.
Review – Dynamics of cortical domains in early Drosophila development
Cortical domains are a central feature of epithelial and polarised cells. Anja Schmidt and Jörg Grosshans present a Review of the dynamics of cortical domains in early Drosophila embryos and discuss underlying mechanisms for formation of cortical domains.
Cell scientist to watch – 2018 Hooke medal winner Andrew McAinsh
“…identify an interesting, good scientific question and try to answer it.”
Andrew McAinsh, Head of Division of Biomedical Sciences at Warwick Medical School, is interested in understanding how the chromosomal multi-protein complex, the kinetochore, ensures error-free chromosome segregation. He is the recipient of the 2018 Hooke medal, established to recognize an emerging leader in cell biology.
We also feature interviews with first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Check out our recent First Person interviews with Thibault Courtheoux and Alghassimou Diallo, Francesco Consolato and Emily Herman.
Articles of interest in our sister journals
Head formation requires Dishevelled degradation that is mediated by March2 in concert with Dapper1
Hyeyoon Lee, Seong-Moon Cheong, Wonhee Han, Youngmu Koo, Saet-Byeol Jo, Gun-Sik Cho, Jae-Seong Yang, Sanguk Kim, Jin-Kwan Han. Development 2018 145: dev143107
PUF-8 facilitates homologous chromosome pairing by promoting proteasome activity during meiotic entry in C. elegans
Ganga Anil Kumar, Kuppuswamy Subramaniam. Development 2018 145: dev163949