Cover: Cytoskeletal reorganization in B cells spreading on an anti-immunoglobulin-coated coverslip. F-actin (red) accumulates at the cell periphery and the microtubule organising centre (MTOC) relocalises to the central region of the cell from which F-actin has been cleared. Microtubules (blue) and CLIP-170 (green) extend from the MTOC and contact the peripheral ring of F-actin. Imaged by stimulated emission depletion microscopy. See article by J. Wang et al. (pp. 1094–1109).