Table of Contents
IN THIS ISSUE
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
- Real-time insights into regulated exocytosis
Summary: This Commentary focuses on recent developments in three-dimensional time-lapse imaging of regulated secretion occurring in living secreting organs.
- Neuropilin 1 binds PDGF-D and is a co-receptor in PDGF-D–PDGFRβ signaling
- Lineage-specific proteins essential for endocytosis in trypanosomes
Summary: Endocytosis is a vital process in most cells, and here we identify important proteins required for this process in trypanosomes. Significantly, these are unique and not present in animals, fungi or plants.
- A functional coupling between CRMP1 and Nav1.7 for retrograde propagation of Semaphorin3A signaling
- GSK3-mediated CLASP2 phosphorylation modulates kinetochore dynamics
Summary: Kinetochore–microtubule interactions are essential for faithful chromosome segregation. Here, we describe consequences of GSK3 phosphorylation-site mutations that control CLASP2 interactions with microtubules during mitosis.
- Proline dehydrogenase promotes senescence through the generation of reactive oxygen species
Highlighted Article: This study reveals a new role of proline dehydrogenase in p53-dependent cellular senescence and raises the possibility that an alteration in amino acid metabolism can promote the senescence process.
- Evolution of the endomembrane systems of trypanosomatids – conservation and specialisation
Summary: The trafficking systems of trypanosomes are shown to vary considerably, with much minimisation in systems with antigenic variation and more complexity in cell invasive forms.
- Neuronal hyperactivity causes Na+/H+ exchanger-induced extracellular acidification at active synapses
Highlighted Article: A novel extracellular pH-indicator that is sensitive to acidic shifts reveals that neuronal hyperactivity causes acidic shifts that are localized to active synapses and generated by the Na+/H+ exchanger.
- The centriolar satellite protein CCDC66 interacts with CEP290 and functions in cilium formation and trafficking
Summary: The retinal degeneration gene product CCDC66 is a microtubule-associated protein that localizes to the centrosome and cilium complex, and functions in cilium formation and recruitment of BBS4 to the cilium.
- Tex19 paralogs are new members of the piRNA pathway controlling retrotransposon suppression
Summary: In vitro and in vivo experiments demonstrate that the two TEX19 paralogs belong to the family of piRNA-interacting proteins.
- Missing-in-metastasis protein downregulates CXCR4 by promoting ubiquitylation and interaction with small Rab GTPases
Summary: MIM promotes CXCR4 ubiquitylation by interacting with AIP4; this interaction is also required for CXCR4 sorting into multivesicular bodies, which is linked to MIM acting as an effector of Rab small GTPases.
- Oxidative stress elicited by modifying the ceramide acyl chain length reduces the rate of clathrin-mediated endocytosis
Summary: Altering sphingolipid acyl chain length causes oxidative stress, reducing transcription of Hsc70 via Sp1, which leads to lower levels of Hsc70-mediated uncoating of clathrin-coated vesicles.
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