Table of Contents
RESEARCH HIGHLIGHT
REVIEWS
- SRF'ing and SAP'ing – the role of MRTF proteins in cell migration
Summary: This Review provides a comprehensive overview of how MRTF regulates cell migration in physiological and pathological contexts by utilizing its canonical SRF-dependent and SRF-independent modes of action.
- p62-mediated phase separation at the intersection of the ubiquitin-proteasome system and autophagy
Summary: This review highlights the recent advances of how the ubiquitin-proteasome system and autophagy can be coordinated by p62-dependent phase separation reactions.
RESEARCH ARTICLES
- Calcium influx mediates the chemoattractant-induced translocation of the arrestin-related protein AdcC in Dictyostelium
Summary: The multimodular arrestin-related protein AdcC from Dictyostelium responds to a calcium increase by translocating to the plasma membrane in a C2- and SAM domain-dependent manner.
- RSPH6A is required for sperm flagellum formation and male fertility in mice
Summary: Removal of RSPH6A via CRISPR/Cas9 results in short-tailed immotile spermatozoa and loss of fertilizing ability in male mice.
- Co-expression of sperm membrane proteins CMTM2A and CMTM2B is essential for ADAM3 localization and male fertility in mice
Highlighted Article: Gene-modification experiments in mice show that co-expression of the testis-specific sperm membrane proteins CMTM2A and CMTM2B is required for fertilization.
- Rab11a–Rab8a cascade regulates the formation of tunneling nanotubes through vesicle recycling
Highlighted Article: Rab11 and Rab8 act to increase the number of TNT-connected cells and the propagation of vesicles between cells in co-culture. These two Rab GTPases act in a cascade, where Rab11 activates Rab8 to form TNTs through VAMP3.
- Chronic starvation induces noncanonical pro-death stress granules
Summary: This work characterizes the mechanisms of formation of a novel type of stress granule that is induced in response to long-term starvation and, unlike previously described stress granules, functions in a pro-death capacity.
- C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37
Highlighted Article: Here, we show that tetraspanin CD37 directly interacts with CLEC-2 in the membrane of dendritic cells, to control dendritic cell migration and podoplanin-induced contractility in lymph node stromal cells.
PREPRINT HIGHLIGHTS
This issue
Other journals from The Company of Biologists
Cell scientists to watch – Gloria Brar and Elçin Ünal
“…it is important for you as an individual scientist to find the best system to address your specific questions and also to look for synergies outside your own talents and knowledge base.”
Gloria Brar is Assistant Professor of Cell and Developmental Biology and Elçin Ünal is Assistant Professor of Genetics, Genomics and Development. They tell us about running complementary labs at UC Berkeley investigating yeast.
Catch up with early-career first authors in our First Person interviews. Recently, we spoke to Norbert Volkmar and Priyanka Kothari.
Editorial - New Editor on Journal of Cell Science
We are very pleased to welcome Asifa Akhtar as an Editor of Journal of Cell Science. Asifa’s expertise covers molecular aspects of the nucleus. Our Editor in Chief Michael Way gives the highlights of her career, filled with outstanding scientific achievements.
Linear ubiquitin chains are crucial modulators of innate and adaptive immune responses that act by regulating inflammatory and cell death signalling. Maureen Spit, Eva Rieser and Henning Walczak put together this poster to explain it.
Review - Lysosomal storage disorders – challenges, concepts and avenues for therapy: beyond rare diseases
André Marques and Paul Saftig review the current knowledge on the cellular processes involved in lysosomal storage disorders and discuss how understanding of these rare disorders could be applied to more common diseases.
The second in our series of cell dynamics meetings now turns to organelles. This May 2019 meeting in Lisbon, Portugal, aims to bring together scientists studying the interface between organelles and the cytoskeleton at different scales and perspectives using a range of model systems. Find out more and apply for your place here. The deadline to apply is 15 February.
Call for papers - Cell Biology of the Immune System
Journal of Cell Science is pleased to welcome submissions for an upcoming special issue on 'Cell Biology of the Immune System' edited by Ana-Maria Lennon-Duménil. We invite you to showcase your breakthrough research on all aspects of cell biology as it relates to the immune system. The articles within this issue will receive extensive exposure to a broad audience of cell biologists and immunologists. Submission deadline: 30 June 2019.
Journal news - New manuscript transfer option
Journal of Cell Science, Journal of Cell Biology and Molecular Biology of the Cell have announced a new manuscript transfer option, which will be available in the first quarter of 2019. It will empower authors whose manuscripts have been declined to seamlessly transfer their manuscripts and associated peer review reports between the journals.
preLights – A complex containing lysine-acetylated actin inhibits the formin INF2
Laura McCormick highlights a recent preprint from Henry Higgs and team which uses some old-school biochemistry techniques to identify a cellular factor that facilitates INF2 auto-inhibition.
Articles of interest in our sister journals
IMP regulates Kuzbanian to control the timing of Notch signalling in Drosophila follicle cells
Weronika Fic, Celia Faria, Daniel St Johnston
Development 2019 146: dev168963
Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling
Thomas Volckaert, Tingting Yuan, Jie Yuan, Eistine Boateng, Seantel Hopkins, Jin-San Zhang, Victor J. Thannickal, Reinhard Fässler, Stijn P. De Langhe
Development 2019 146: dev166454