Table of Contents
RESEARCH HIGHLIGHT
REVIEWS
- SRF'ing and SAP'ing – the role of MRTF proteins in cell migration
Summary: This Review provides a comprehensive overview of how MRTF regulates cell migration in physiological and pathological contexts by utilizing its canonical SRF-dependent and SRF-independent modes of action.
- p62-mediated phase separation at the intersection of the ubiquitin-proteasome system and autophagy
Summary: This review highlights the recent advances of how the ubiquitin-proteasome system and autophagy can be coordinated by p62-dependent phase separation reactions.
RESEARCH ARTICLES
- Calcium influx mediates the chemoattractant-induced translocation of the arrestin-related protein AdcC in Dictyostelium
Summary: The multimodular arrestin-related protein AdcC from Dictyostelium responds to a calcium increase by translocating to the plasma membrane in a C2- and SAM domain-dependent manner.
- RSPH6A is required for sperm flagellum formation and male fertility in mice
Summary: Removal of RSPH6A via CRISPR/Cas9 results in short-tailed immotile spermatozoa and loss of fertilizing ability in male mice.
- Co-expression of sperm membrane proteins CMTM2A and CMTM2B is essential for ADAM3 localization and male fertility in mice
Highlighted Article: Gene-modification experiments in mice show that co-expression of the testis-specific sperm membrane proteins CMTM2A and CMTM2B is required for fertilization.
- Rab11a–Rab8a cascade regulates the formation of tunneling nanotubes through vesicle recycling
Highlighted Article: Rab11 and Rab8 act to increase the number of TNT-connected cells and the propagation of vesicles between cells in co-culture. These two Rab GTPases act in a cascade, where Rab11 activates Rab8 to form TNTs through VAMP3.
- Chronic starvation induces noncanonical pro-death stress granules
Summary: This work characterizes the mechanisms of formation of a novel type of stress granule that is induced in response to long-term starvation and, unlike previously described stress granules, functions in a pro-death capacity.
- C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37
Highlighted Article: Here, we show that tetraspanin CD37 directly interacts with CLEC-2 in the membrane of dendritic cells, to control dendritic cell migration and podoplanin-induced contractility in lymph node stromal cells.
PREPRINT HIGHLIGHTS
This issue
Other journals from The Company of Biologists
Cell science at a glance - functions of actin in mouse oocytes
This Cell Science at a Glance article from Melina Schuh and colleagues summarizes the many functions of the actin cytoskeleton in oocytes, with a focus on findings from the mouse model system.
Review - nε-lysine acetylation in the endoplasmic reticulum
Mark A. Farrugia and Luigi Puglielli’s Review summarizes recent studies that underscore the importance of the endoplasmic reticulum acetylation process in maintaining protein homeostasis and autophagy within the secretory pathway.
“I have always been, and I am, very excited about collaborations.”
Tobias Zech established his research group at the University of Liverpool. His group studies processes of cell migration and cancer cell invasion, with an emphasis on actin dynamics and receptor trafficking. He spoke to us about what inspires him, the molecular mechanisms that drive invasive cell migration in a 3D matrix environment and how he recruits team members.
Catch up with early-career first authors in our First Person interviews. Recently, we spoke to Ahmed Elbediwy, Kaiyuan Wu, Yihua Wang and Sei Yoshida.
Editorial - Parlez vous immunology?
![NIAID [CC BY 2.0 (https://creativecommons.org/licenses/by/2.0)], via Wikimedia Commons](/sites/default/files/Snippet/Human_Natural_Killer_Cell-snippet.jpg)
Our fourth Special Issue will focus on the cell biology of the immune system, guest edited by Ana-Maria Lennon-Duménil. In this Editorial our Editor-in-Chief Michael Way explains why he is looking forward to reading about the special language of immunology.
Research Highlight - Cataract treatment: beware of fibronectin and TGFβ
Wounding-related changes in the extracellular matrix induce abnormal TGFβ activation and differentiation of lens epithelial cells that could contribute to vision loss after cataract surgery. Musil and colleagues describe more in their Research Article.
JCS Meeting – Cell dynamics: organelle-cytoskeleton interface
The second in our series of cell dynamics meetings now turns to organelles. This May 2019 meeting in Lisbon, Portugal, aims to bring together scientists studying the interface between organelles and the cytoskeleton at different scales and perspectives using a range of model systems. Find out more and apply for your place here.
Journal news – New fast-track decision process
Do you have a paper with reviews from another journal that you’d like to submit to Journal of Cell Science? We will fast-track your paper and give you an initial decision within a week. Find out more here.
Meet the team
Meet the Journal of Cell Science team at the ASCB/EMBO 2018 Meeting in San Diego. Editor-in-Chief Michael Way, Executive Editor Sharon Ahmad, Reviews Editor Petra Gross and Features & Reviews Editor Manuel Breuer will be at Booth 1030 between 1:30-3:30 pm on Sunday and Monday.
preLights - Refolding activity of bacterial Hsp90 in vivo reveals ancient chaperoning function
Tessa Sinnige highlights a preprint from Stefan G.D. Rudiger and colleagues, about clever experiments which reveal the importance of Hsp90 in refolding proteins after heat shock in E. coli.
Catch up with recent preLights selected for the cell science community in our latest Table of Contents.
Articles of interest in our sister journals
The Ric-8A/Gα13/FAK signalling cascade controls focal adhesion formation during neural crest cell migration in Xenopus
Gabriela Toro-Tapia, Soraya Villaseca, Andrea Beyer, Alice Roycroft, Sylvain Marcellini, Roberto Mayor, Marcela Torrejón
Development 2018 145: dev164269
Vangl2-dependent regulation of membrane protrusions and directed migration requires a fibronectin extracellular matrix
Anna M. Love, Dianna J. Prince, Jason R. Jessen
Development 2018 145: dev165472