In this new poster and accompanying article, Anna Castro and Thierry Lorca explain how the Gwl–Arpp19–Ensa–PP2A-B55 axis act as a molecular switch to turn on and off PP2A-B55 activity. Gwl modulates oncogenic properties of cells and nutrient deprivation influences Gwl activity.

Apical surfaces of epithelial cells are characterized by the presence of abundant F-actin-based microvilli. Thaher Pelaseyed and Anthony Bretscher outline recent insights into regulation and maintenance of microvilli and stereocilia.

Integrin-linked kinase (ILK) constitutes a hub for integrin-mediated signalling at focal adhesions. The interaction between ILK and kindlins is well documented, but a lack of molecular details has hindered insight into its significance. David Calderwood and colleagues now identify a binding site for kindlin-2 on ILK, and show that disrupting kindlin-2 binding diminishes localisation to focal adhesions and impairs cell spreading.

Have you seen our First Person interviews with the early-career first authors of our papers? The authors talk about their work in and out of the lab, the journeys that led them to where they are now and the scientists who inspired them along the way. Recently, we caught up with first authors Yasmin Kadry, Dennis Klug and Khamal Kwesi Ampah.

JCS Meeting – Cell dynamics: organelle-cytoskeleton interface

The second in our series of cell dynamics meetings now turns to organelles. This May 2019 meeting in Lisbon, Portugal, aims to bring together scientists studying the interface between organelles and the cytoskeleton at different scales and perspectives using a range of model systems. Find out more and apply for your place here.

Journal news – New fast-track decision process

Do you have a paper with reviews from another journal that you’d like to submit to Journal of Cell Science? We will fast-track your paper and give you an initial decision within a week. Find out more here.

Gautam Dey highlights a preprint from W. E. Moerner and colleagues, describing how super-resolution fluorescence microscopy reveals that beyond the diffraction limit, the primary cilium doesn’t entirely look like a cylinder.