Cell science at a glance – Viral escape from endosomes and host detection at a glance

In this poster and article Jacqueline Staring, Matthijs Raaben and Thijn R. Brummelkamp summarize the current knowledge on the escape of viruses from the endosomal compartment and the cellular detection mechanisms that counteract it.

Review - The interplay between exosomes and autophagy

Jing Xu, Robert Camfield and Sharon M. Gorski review the molecular machinery shared between exosome biogenesis and the autophagy pathway, and describe the ‘partners in crime’ coordination between these two processes in multiple contexts, including neurodegeneration and cancer.

First Person interviews

Have you seen our First Person interviews with the early-career first authors of our papers? The authors talk about their work in and out of the lab, the journeys that led them to where they are now and the scientists who inspired them along the way. Recently, we caught up with first authors Kevin Adam, Vibha Singh and Jan Steinkühler.

Research highlight – Cytosolic cMyBP-C binds to sarcoplasmic reticulum RyR2

Cardiac muscle contraction is initiated by calcium channel RyR2, and immunoglobulin cMyBP-C is a major regulator of acto-myosin cross-bridge kinetics and myocardial contraction. In a new Research Article, Anthony Lai and colleagues provide the first evidence for a functional association between these two vital cardiac proteins, with potential clinical relevance for inherited cardiac disorders.

JCS Meeting – Cell dynamics: organelle-cytoskeleton interface