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Cell science at a glance – Viral escape from endosomes and host detection at a glance
In this poster and article Jacqueline Staring, Matthijs Raaben and Thijn R. Brummelkamp summarize the current knowledge on the escape of viruses from the endosomal compartment and the cellular detection mechanisms that counteract it.
Review - The interplay between exosomes and autophagy
Jing Xu, Robert Camfield and Sharon M. Gorski review the molecular machinery shared between exosome biogenesis and the autophagy pathway, and describe the ‘partners in crime’ coordination between these two processes in multiple contexts, including neurodegeneration and cancer.
First Person interviews
Have you seen our First Person interviews with the early-career first authors of our papers? The authors talk about their work in and out of the lab, the journeys that led them to where they are now and the scientists who inspired them along the way. Recently, we caught up with first authors Kevin Adam, Vibha Singh and Jan Steinkühler.
Research highlight – Cytosolic cMyBP-C binds to sarcoplasmic reticulum RyR2
Cardiac muscle contraction is initiated by calcium channel RyR2, and immunoglobulin cMyBP-C is a major regulator of acto-myosin cross-bridge kinetics and myocardial contraction. In a new Research Article, Anthony Lai and colleagues provide the first evidence for a functional association between these two vital cardiac proteins, with potential clinical relevance for inherited cardiac disorders.
JCS Meeting – Cell dynamics: organelle-cytoskeleton interface
The second in our series of cell dynamics meetings now turns to organelles. This May 2019 meeting in Lisbon, Portugal, aims to bring together scientists studying the interface between organelles and the cytoskeleton at different scales and perspectives using a range of model systems. Find out more and register your interest here. Registration opens in September.
preLights – Light at the end of the tunnel?
Gautam Dey highlights a preprint from David Stephens and colleagues that describes a new reporter for pulsed collagen secretion, providing support for a direct route from ER to Golgi. The preLight also features a response from the authors on the potential of their tool to define different aspects of procollagen trafficking, and opening the door for a machine-learning collaboration.
Articles of interest in our sister journals
Christian Ghiglione, Patrick Jouandin, Delphine Cérézo, Stéphane Noselli. Development 2018 145: dev161117
Induced cell fate transitions at multiple cell layers configure haustorium development in parasitic plants
Takanori Wakatake, Satoko Yoshida, Ken Shirasu. Development 2018 145: dev164848