Issues

Summary: Robertsonian chromosomes are common in nature and can lead to reproductive isolation and speciation. Recent technological advances have led to new insights into how they form in the human genome.

Summary: Expansion microscopy is a sample preparation technique that allows increased resolution in many settings by physically enlarging specimens and can be easily adopted in cell biology laboratories.

Summary: The co-expression of select connexin isoforms enhances the ability of Cx31.1 to form gap junctions in rat epidermal keratinocytes.

Summary: An FBXB-65-dependent pathway post-translationally modifies UNC-104 (a KIF1A homolog) and controls motor levels on cargo, cargo movement and C. elegans lifespan.

Highlighted Article: Crosstalk of two types of inclusion body (IB), Syn-aggresomes and Lewy body-like (LB-like) IBs, provide quality control for amyloidogenic α-synuclein. Among these, perinuclear LB-like IBs are neurodegenerative and act by disrupting the nuclear lamina.

Highlighted Article: The Rab27a guanine nucleotide exchange factor MADD is involved in the cell-mediated killing of cytotoxic lymphocytes.

Summary: Aster centration occurs at entry into mitosis while MT-based cytoplasmic pulling remains active, and when MT-based cortical pulling is switched off there is a coincident transient fall in cortical tension.

Highlighted Article: An analysis of the complex development, interactions and characteristics of photoreceptor microvilli (calyceal processes).