Cell scientist to watch – Dana Branzei

“…there is no elevator to success, one really has to take the stairs.”

Dana Branzei’s is a PI at the Institute of Molecular Oncology Foundation (IFOM) in Milan, Italy, where her lab investigate mechanistic interplay of DNA damage response and regulatory pathways of chromosome structure during replication. In an interview, she shares why hard work and humility are key to a successful career.

Look out for First Person, our new interview series with early-career researchers. In this issue, we hear from Brandy Hyndman and Mathieu Crupi, Jinhang Hu and Yi-Wen Xu.

Opinion – Unconventional secretion of FGF2 and IL-1β

For the majority of cargo proteins secreted by unconventional means the precise molecular details of secretion routes have remained elusive. Here, David Brough, Pablo Pelegrin and Walter Nickel summarise the emerging case for membrane pore formation as a mechanism for the unconventional secretion pathways for IL-1β and FGF2.

Review – Role of the ECM in notochord formation, function and disease

The correct deposition and organisation of the ECM is essential for proper notochord morphogenesis.  Diana Corallo and colleagues review the role of ECM molecules in the formation and function of the notochord, as well as in the pathogenesis of notochord-related diseases.

Articles of interest in other journals

From Development:

DNA damage induces a kinetochore-based ATM/ATR-independent SAC arrest unique to the first meiotic division in mouse oocytes
Simon I. R. Lane, Stephanie L. Morgan, Tianyu Wu, Josie K. Collins, Julie A. Merriman, Elias ElInati, James M. Turner, Keith T. Jones
Development 2017 144: 3475-3486; doi: 10.1242/dev.153965

Afadin orients cell division to position the tubule lumen in developing renal tubules
Lei Gao, Zhufeng Yang, Chitkale Hiremath, Susan E. Zimmerman, Blake Long, Paul R. Brakeman, Keith E. Mostov, David M. Bryant, Katherine Luby-Phelps, Denise K. Marciano
Development 2017 144: 3511-3520; doi: 10.1242/dev.148908

Transfer to Biology Open

If your submission to Journal of Cell Science is unsuccessful, did you know you can transfer your paper and any reviews directly to our sister journal, Biology Open? The majority of papers transferred with reviews are accepted for publication. Find out how here.