RT Journal Article
SR Electronic
T1 GGA proteins: new players in the sorting game
JF Journal of Cell Science
JO J. Cell Sci.
FD The Company of Biologists Ltd
SP 3413
OP 3418
VO 114
IS 19
A1 Boman, Annette L.
YR 2001
UL http://jcs.biologists.org/content/114/19/3413.abstract
AB The GGA proteins are a novel family of proteins that were discovered nearly simultaneously by several labs studying very different aspects of membrane trafficking. Since then, several studies have described the GGA proteins and their functions in yeast and mammalian cells. Four protein domains are present in all GGA proteins, as defined by sequence homology and function. These different domains interact directly with ARF proteins, cargo and clathrin. Alteration of the levels of GGA proteins by gene knockout or overexpression affects specific trafficking events between the trans-Golgi network and endosomes. These data suggest that GGAs function as ARF-dependent, monomeric clathrin adaptors to facilitate cargo sorting and vesicle formation at the trans-Golgi network.