Table 2.

Aurora-A substrates and cofactors and their involvement in Aurora-A-mediated processes

Aurora-A substrate Process
CDC25B Mitotic entry (through activation of cyclin-B1–Cdk1)
CPEB Translational control of cell cycle regulators
Eg5 Centrosome separation, mitotic spindle assembly
LATS2 Centrosome maturation
NDEL1 Centrosome maturation, mitotic entry, centrosome separation
TACC Astral MT stability, mitotic spindle assembly
Aurora-A cofactor Process
Ajuba Centrosome maturation
Bora Centrosome maturation, asymmetric cell division
PAK1 Centrosome maturation
Tpx2 Centrosome maturation, mitotic spindle assembly