Table 1.

Cadherin switching during normal development and tumorigenesis

Switch Example Reference
Cadherin switching during normal development
   From E-cadherin to N-cadherin Primitive streak formation (Nakagawa and Takeichi, 1995)
Neural plate invagination (Hatta and Takeichi, 1986)
   From N-cadherin to cadherin 6B Generation of neural crest cells from neural plate (Nakagawa and Takeichi, 1995)
   From N-cadherin and cadherin 6B to cadherins 7 When neural crest cells become migratory (Nakagawa and Takeichi, 1995)
   From a complex mixture of cadherins to R-cadherin Kidney morphogenesis (Dahl et al., 2002)
   From E- and P-cadherin to E-cadherin Epidermal stratification (Jensen et al., 1997)
Cadherin switching during tumorigenesis
   From E-cadherin to N-cadherin Melanoma (Li et al., 2001)
TGFβ-induced EMT in mammary epithelial cells (Maeda et al., 2005; Miettinen et al., 1994; Piek et al., 1999)
Prostate cancer (Gravdal et al., 2007; Jaggi et al., 2006; Tomita et al., 2000)
Breast cancer (Han et al., 1999; Hazan et al., 2000; Nieman et al., 1999)
Pancreatic cancer (Hotz et al., 2007; Nakajima et al., 2004)
   From E-cadherin to T-cadherin Hepatocellular carcinoma (Riou et al., 2006)
   From E-cadherin to P-cadherin Pancreatic cancer (Taniuchi et al., 2005)
Gastric cancer (Shimoyama and Hirohashi, 1991)
   From E-cadherin to cadherin 11 Prostate cancer (Bussemakers et al., 2000; Tomita et al., 2000)
Breast cancer (Pishvaian et al., 1999)
   From E- and P-cadherin to N-cadherin Oral squamous cell carcinoma (Chen et al., 2004; Islam et al., 1996; Pyo et al., 2007)
   From N-cadherin to E-cadherin Ovarian cancer (Patel, I. et al., 2003; Wong et al., 1999)