Table 1.

Findings in 17 Itgb8–/– adult mice

Age at death (days) Observations Cause of death
21 Impaired mobility D
25 Impaired mobility D
26 Impaired mobility D
35 Impaired mobility D
40 Rectal prolapse, periorbital abscess S
56 Weakness in hind limbs S
60 Impaired mobility D
62 Impaired mobility D
65 Rectal prolapse S
65 Weakness in hind limbs S
66 Sparse hair D
72 Weakness in hind limbs S
72 Impaired mobility D
72 Genital prolapse S
72 Immobile S
86 Weakness in hind limbs, pyometra S
92 Impaired mobility D
74 Weakness in hind limbs S
  • Itgb8–/– mice were observed until death or until sacrifice was required because of morbidity (which was most often due to poor mobility and inability to feed)

    D, natural death; S; sacrificed