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Apoptosis

  • REVIEW
    The resurrection of the PIDDosome – emerging roles in the DNA-damage response and centrosome surveillance
    Valentina Sladky, Fabian Schuler, Luca L. Fava, Andreas Villunger
    J Cell Sci 2017 130: 3779-3787; doi: 10.1242/jcs.203448

    Summary: Discussion of the biology of the PIDDosome multiprotein complex and of recent advances that link PIDDosome-dependent CASP2 activation to p53 activation in response to extra centrosomes.

  • RESEARCH ARTICLE
    Regulation of Cx37 channel and growth-suppressive properties by phosphorylation
    Nicole L. Jacobsen, Tasha K. Pontifex, Hanjun Li, Joell L. Solan, Paul D. Lampe, Paul L. Sorgen, Janis M. Burt
    J Cell Sci 2017 130: 3308-3321; doi: 10.1242/jcs.202572

    Summary: Connexin 37 may serve as a molecular switch that contributes to cell fate decisions, between cell cycle arrest, cell cycle progression and cell death, in a phosphorylation- and channel-dependent manner.

  • RESEARCH ARTICLE
    L-leucyl-L-leucine methyl ester does not release cysteine cathepsins to the cytosol but inactivates them in transiently permeabilized lysosomes
    Urska Repnik, Marita Borg Distefano, Martin Tobias Speth, Matthew Yoke Wui Ng, Cinzia Progida, Bernard Hoflack, Jean Gruenberg, Gareth Griffiths
    J Cell Sci 2017 130: 3124-3140; doi: 10.1242/jcs.204529

    Summary: L-leucyl-L-leucine methyl ester (LLOMe) permeabilizes lysosomal membranes and destabilizes lysosomal enzymes. LLOMe-induced apoptosis is independent of cysteine cathepsin proteolytic activities in the cytosol.

  • RESEARCH ARTICLE
    A mutation in keratin 18 that causes caspase-digestion resistance protects homozygous transgenic mice from hepatic apoptosis and injury
    Han-Na Yoon, Sung-Yeon Yoon, Jin-Hyuck Hong, Nam-On Ku
    J Cell Sci 2017 130: 2541-2550; doi: 10.1242/jcs.187492

    Summary: K18 that is resistant to caspase digestion helps to maintain keratin filament organization and delays apoptosis, thereby protecting liver from injury.

  • RESEARCH ARTICLE
    The cell adhesion molecule CHL1 interacts with patched-1 to regulate apoptosis during postnatal cerebellar development
    Jelena Katic, Gabriele Loers, Jelena Tosic, Melitta Schachner, Ralf Kleene
    J Cell Sci 2017 130: 2606-2619; doi: 10.1242/jcs.194563

    Summary: The adhesion molecule close homolog of L1 (CHL1) is a novel ligand of the hedgehog receptor patched-1. The CHL1–patched-1 interaction promotes survival of cerebellar granule cells during postnatal mouse development.

  • RESEARCH ARTICLE
    Caspase-9 has a nonapoptotic function in Xenopus embryonic primitive blood formation
    Hong Thi Tran, Mathias Fransen, Dionysia Dimitrakopoulou, Griet Van Imschoot, Nicolas Willemarck, Kris Vleminckx
    J Cell Sci 2017 130: 2371-2381; doi: 10.1242/jcs.186411

    Summary: Fluorescent transgenic reporter constructs detecting caspase activity were designed and integrated in Xenopus embryos, revealing an unexpected nonapoptotic function for the initiator caspase-9 in primitive blood formation.

  • RESEARCH ARTICLE
    Phosphorylation of XIAP by CDK1–cyclin-B1 controls mitotic cell death
    Ying Hou, Lindsey A. Allan, Paul R. Clarke
    J Cell Sci 2017 130: 502-511; doi: 10.1242/jcs.192310

    Summary: Phosphorylation of XIAP by CDK1–cyclin-B1 controls the onset of mitotic cell death, which is important for surveillance against defects in mitosis and the response to cancer drugs that target cell division.

  • RESEARCH ARTICLE
    Mortalin-mediated and ERK-controlled targeting of HIF-1α to mitochondria confers resistance to apoptosis under hypoxia
    Ilias Mylonis, Maria Kourti, Martina Samiotaki, George Panayotou, George Simos
    J Cell Sci 2017 130: 466-479; doi: 10.1242/jcs.195339

    Summary: An unconventional anti-apoptotic function of HIF-1α during hypoxia involves ERK-regulated association of its C-terminal domain with outer mitochondrial membrane proteins.

  • SHORT REPORT
    Necrotic pyknosis is a morphologically and biochemically distinct event from apoptotic pyknosis
    Lin Hou, Kai Liu, Yuhong Li, Shuang Ma, Xunming Ji, Lei Liu
    J Cell Sci 2016 129: 3084-3090; doi: 10.1242/jcs.184374

    Summary: Genetic evidence suggests that necrotic pyknosis is distinct from apoptotic pyknosis because of phosphorylation of BAF, which results in a transient detachment of chromatin from the nuclear envelope.

  • RESEARCH ARTICLE
    Paracrine effect of carbon monoxide – astrocytes promote neuroprotection through purinergic signaling in mice
    Cláudia S. F. Queiroga, Raquel M. A. Alves, Sílvia V. Conde, Paula M. Alves, Helena L. A. Vieira
    J Cell Sci 2016 129: 3178-3188; doi: 10.1242/jcs.187260

    Summary: CO modulates astrocytic metabolism and initiates communication pathways in a paracrine manner in order to rescue neurons from cell death, which is dependent on P1 adenosine, P2 ATP and TrkB receptors.

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