- The focal adhesion targeting domain of p130Cas confers a mechanosensing function
- Development and dynamics of cell polarity at a glance
Summary: Cell- and tissue-polarity protein complexes are modular and generate diverse types of polarity, including epithelial, migratory and stem cell polarities, and contribute to cell fate specification.
- A proteomic approach to identify endosomal cargoes controlling cancer invasiveness
Highlighted Article: This paper describes a novel proteomic approach to identify pro-invasive cargoes, which we have used to determine that Rab17 controls Vamp8 levels to drive neuropilin-2 trafficking, promoting invasion.
- ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2–MRCKα balance
Summary: ICAP-1 monoubiquitylation by Smurf1 coordinates fibronectin matrix density and rigidity sensing for cell migration by promoting the switch from a ROCK2- to an MRCKα-mediated contractility pathway.
- Microtubules in 3D cell motility
Summary: We discuss microtubule functions that control cell shape and motility in 3D matrices, and the differences of microtubule involvement in cell morphogenesis and motility between 2D and 3D environments.
- Non-invasive single-cell biomechanical analysis using live-imaging datasets
Summary: An automated image-morphing-based method, intricately coupled with automated segmentation and multi-criterion path alignment, for a comprehensive label-free analysis of live-cell biomechanics, morphology and migration.
- CYLD – a deubiquitylase that acts to fine-tune microtubule properties and functions
Summary: This Commentary focuses on recent literature that shows how CYLD impacts on microtubule properties and functions, and discusses the challenges we face when interpreting results obtained from different experimental systems.
- Reciprocal regulation of actin cytoskeleton remodelling and cell migration by Ca2+ and Zn2+: role of TRPM2 channels
Highlighted article: Migration of some cancer cell lines is regulated by TRPM2 channels, which modulate the levels of Zn2+ and Ca2+ ions. In turn, these two ions regulate actin cytoskeleton dynamics in a reciprocal fashion.
- PP2A binds to the LIM domains of lipoma-preferred partner through its PR130/B″ subunit to regulate cell adhesion and migration
Highlighted Article: The importance of localised regulation of protein dephosphorylation in cell adhesion and migration through demonstration of a new interaction between the LIM protein LPP and PP2A comprising the Bʹʹ/PR130 subunit.