- Attenuation of N-glycosylation causes polarity and adhesion defects in the C. elegans embryo
Summary: Upon reduction of N-glycosylation, E-cadherin is not efficiently localized in the cell–cell contact site contributing to adhesion defects in the two-cell C. elegans embryo. This phenotype is rescued by concomitant loss of cell polarity.
- ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture
Summary: ZO-1–occludin interactions provide signals that are required for polarization and 3D morphogenesis; these results elucidate the contributions of tight junction structural proteins to 3D epithelial organization.
- A new isoform of Drosophila non-muscle Tropomyosin 1 interacts with Kinesin-1 and functions in oskar mRNA localization
Highlighted Article: A previously uncharacterized isoform of Tropomyosin, referred to as Tm1C, directly interacts with Kinesin heavy chain and functions along with this microtubule motor to localize oskar mRNA in Drosophila oocytes.
- PRL-3 disrupts epithelial architecture by altering the post-mitotic midbody position
Summary: The cancer-promoting phosphatase PRL-3 triggers ectopic lumen formation through midbody mispositioning by accelerating cytokinesis, suggesting a new oncogenic mechanism.
- Local Ras activation, PTEN pattern, and global actin flow in the chemotactic responses of oversized cells
Highlighted Article: The chemotactic response system of Dictyostelium cells can accommodate larger cells, in a way that involves asymmetric Ras activation in turning protrusions, unconventional PTEN patterns and tail-directed actin flow during the establishment of polarity.
- Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body
Summary: The nascent mammalian epidermis spreads to enclose the embryo trunk through a process akin to epiboly, which has important implications for human birth defects of the abdominal wall.