Cytoskeleton
- Premature termination codon readthrough in human cells occurs in novel cytoplasmic foci and requires UPF proteins
Summary: The cytoskeleton transports premature termination codon-containing mRNAs to be degraded by nonsense-mediated decay or to be read through in specific cytoplasmic foci called readthrough bodies.
- Loss of β-PIX inhibits focal adhesion disassembly and promotes keratinocyte motility via myosin light chain activation
Highlighted Article: Unexpectedly, β-PIX loss in keratinocytes increases the migration speed of single cells and promotes collective cell migration during wound repair by promoting actomyosin fiber contraction.
- Pseudostratified epithelia – cell biology, diversity and roles in organ formation at a glance
Summary: Here, we give readers an overview of the biology and characteristics of pseudostratified epithelia.
- Lineage-specific proteins essential for endocytosis in trypanosomes
Summary: Endocytosis is a vital process in most cells, and here we identify important proteins required for this process in trypanosomes. Significantly, these are unique and not present in animals, fungi or plants.
- Giant FAZ10 is required for flagellum attachment zone stabilization and furrow positioning in Trypanosoma brucei
Summary: Functional characterization of the T. brucei giant protein FAZ10 reveals it has roles in flagellar attachment, nucleus and kinetoplast positioning and, uniquely for a FAZ protein, a direct role in cytokinesis.
- Deep nuclear invaginations are linked to cytoskeletal filaments – integrated bioimaging of epithelial cells in 3D culture
Summary: Fluorescence and electron microscopy analysis of HMECs grown in 3D reveals deep nuclear invaginations and tunnels that wrap around cytoskeleton cables, thus connecting the microenvironment to the nucleus.
- The integrin adhesome network at a glance
Summary: We have generated a new depiction of the integrin adhesome network that integrates experimentally derived IAC proteomes with the literature-curated adhesome to bridge the knowledge gap between these two resources.
- Desmin and αB-crystallin interplay in the maintenance of mitochondrial homeostasis and cardiomyocyte survival
Highlighted Article: Both desmin and its partner chaperone αB-crystallin associate with mitochondria–sarcoplasmic-reticulum contact sites (MAMs), stabilizing MICOS super-complexes, and thus contributing to proper mitochondrial cristae structure–function.
- Drosophila Ringmaker regulates microtubule stabilization and axonal extension during embryonic development
Summary: We report the characterization of Drosophila Ringmaker (Ringer), and demonstrate that Ringer regulates axonal growth by affecting microtubular organization during CNS development.