- A new HECT ubiquitin ligase regulating chemotaxis and development in Dictyostelium discoideum
Highlighted Article: Disrupting a new HECT ubiquitin ligase restores chemotaxis and development in a Dictyostelium mutant deficient in the Pia subunit of the TORC2 complex (Rictor in mammals), which regulates cAMP relay and cell migration.
- Xpf suppresses the mutagenic consequences of phagocytosis in Dictyostelium
- The role of ADP-ribosylation in regulating DNA interstrand crosslink repair
Summary: Here, we identify a role for post-translational modification ADP-ribosylation in the response to DNA interstrand crosslinks in the model Dictyostelium.
- The GATA transcription factor gene gtaG is required for terminal differentiation in Dictyostelium
Summary: GtaG is involved in the production of two culmination-signaling molecules – c-di-GMP and the spore differentiation factor SDF-1. Addition of c-di-GMP rescues culmination and spore-formation deficiencies of gtaG mutant.
- Altered N-glycosylation modulates TgrB1- and TgrC1-mediated development but not allorecognition in Dictyostelium
Summary: In Dictyostelium, compromised N-glycosylation, but not ER stress, caused by tunicamycin treatment or alg9 mutation, partially suppresses the developmental arrest in tgrB1-tgrC1-defective mutants.