- Endocytic turnover of Rab8 controls cell polarization
- Myosin VI facilitates connexin 43 gap junction accretion
- Multiple routes of endocytic internalization of PDGFRβ contribute to PDGF-induced STAT3 signaling
Highlighted Article: PDGFRβ is internalized via clathrin-dependent and -independent routes, the latter involving RhoA–ROCK, Cdc42 and galectin-3. Inhibition of any route impairs activation of STAT3 but not other PDGFRβ effectors.
- Vps34 regulates Rab7 and late endocytic trafficking through recruitment of the GTPase-activating protein Armus
Summary: The class III PI3K Vps34 activates Armus (TBC1D2), a Rab7 GTPase-activating protein, to regulate endosomal trafficking.
- Transient fusion ensures granule replenishment to enable repeated release after IgE-mediated mast cell degranulation
- VEGF induces signalling and angiogenesis by directing VEGFR2 internalisation through macropinocytosis
Highlighted Article: VEGFR2 internalises constitutively through clathrin-mediated endocytosis, whereas VEGF induces a new internalisation itinerary for VEGFR2 through macropinocytosis, which is essential for its signalling.
- Numb directs the subcellular localization of EAAT3 through binding the YxNxxF motif
Summary: Numb binds the YxNxxF motif in the cytoplasmic C-terminus of EAAT3 and drives its endocytosis in non-polarized cells and its apical sorting in polarized cells.
- PI3K regulates endocytosis after insulin secretion by mediating signaling crosstalk between Arf6 and Rab27a
Summary: The insulin secretagogue glucose activates PI3K and induces endocytosis through promoting signaling crosstalk between Arf6 and Rab27a pathways.
- CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor cells
Summary: CULD, a CUB- and LDLa-domain transmembrane protein that is enriched in photoreceptor cells, is required in endocytic turnover of rhodopsin and TRPL.