- Kinesin-1 sorting in axons controls the differential retraction of arbor terminals
Summary: Axonal transport of kinesin-1 and microtubule dynamics are differentially regulated between terminals in a single axon, and contribute to shaping the axonal arbor by differentially regulating retraction of terminals.
- Drosophila Kette coordinates myoblast junction dissolution and the ratio of Scar-to-WASp during myoblast fusion
Summary: The Drosophila protein Kette is essential for myoblast fusion. It controls the dissolution of electron-dense plaques and the ratio of Scar and WASp proteins in fusion-competent myoblasts during fusion pore formation.
- A new role for cofilin in retinal neovascularization
Summary: Pak1 and its downstream effector cofilin play an essential role in VEGFA-induced angiogenic events in human retinal microvascular endothelial cells in vitro and hypoxia-induced retinal neovascularization in vivo.
- Degradation of aggregated LDL occurs in complex extracellular sub-compartments of the lysosomal synapse
Summary: Macrophages use extracellular compartments, termed lysosomal synapses, that are topologically complex, have a convoluted structure and contain sub-regions that are acidified to digest aggregated lipoproteins.