- Interplay between a cytosolic and a cell surface carbonic anhydrase in pH homeostasis and acid tolerance of Leishmania
Summary: Leishmania parasites depend on the concerted action of a cytosolic and a cell surface carbonic anhydrase in order to buffer their cytosol and to proliferate in acidic environments.
- The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection
Summary: The Src kinases Hck, Fgr and Lyn, and the Abl kinase Arg control Leishmania uptake by macrophages and subsequent infection. Hence, kinase inhibitors could potentially be used to treat leishmaniasis.
- Flagellar pocket restructuring through the Leishmania life cycle involves a discrete flagellum attachment zone
Summary: Leishmania parasites have a highly structured flagellar pocket, including a structure homologous to the Trypanosoma brucei flagellum attachment zone, which undergoes structural adaptations in different life cycle stages.