- Mouse Stbd1 is N-myristoylated and affects ER–mitochondria association and mitochondrial morphology
Highlighted Article: The glycogen-binding protein Stbd1 is N-myristoylated and targeted to ER–mitochondria contact sites. Stbd1 loss- or gain-of-function affects ER–mitochondria association and mitochondrial morphology.
- Mortalin-mediated and ERK-controlled targeting of HIF-1α to mitochondria confers resistance to apoptosis under hypoxia
Summary: An unconventional anti-apoptotic function of HIF-1α during hypoxia involves ERK-regulated association of its C-terminal domain with outer mitochondrial membrane proteins.
- Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology
Summary: Comparative proteomics revealed that mitochondrial proteins are a major target for α-synuclein. Sideroflexin 3 (SFXN3) was identified as one α-synuclein-dependent mitochondrial protein capable of altering synaptic morphology in vivo.
- Plant mitochondria contain the protein translocase subunits TatB and TatC
Summary: This paper provides evidence that Arabidopsis thaliana mitochondria contain two subunits of a twin arginine translocation (Tat) pathway, indicating the presence of an active Tat pathway in plants.
- Desmin and αB-crystallin interplay in the maintenance of mitochondrial homeostasis and cardiomyocyte survival
Highlighted Article: Both desmin and its partner chaperone αB-crystallin associate with mitochondria–sarcoplasmic-reticulum contact sites (MAMs), stabilizing MICOS super-complexes, and thus contributing to proper mitochondrial cristae structure–function.
- The N-terminus of survivin is a mitochondrial-targeting sequence and Src regulator
Summary: The proline-rich N-terminal ten amino acids of survivin is a mitochondrial-targeting domain and a regulator of the proto-oncogene Src. Hence, survivin could act in concert with Src to promote tumorigenesis.
- CCN6 regulates mitochondrial function
Summary: CCN6, or Wnt-induced signaling protein 3 (WISP3), regulates mitochondrial electron transport and ATP synthesis. The influence of CCN6 on mitochondrial function might impact cell growth and differentiation.