- Mitochondrial depolarization in yeast zygotes inhibits clonal expansion of selfish mtDNA
Summary: Uncouplers activate mitochondrial degradation in heteroplasmic yeast zygotes and prevent clonal expansion of selfish mitochondrial DNA. This effect requires mitochondrial fission and autophagy.
- OPA1 processing in cell death and disease – the long and short of it
Summary: Proteolytic processing of the dynamin-like GTPase OPA1 is emerging as a crucial regulator of mitochondrial dynamics and quality control, with exciting therapeutic potential in mitochondrial disease.
- Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology
Summary: Overexpression of the pro-apoptotic protein appoptosin impairs interaction of the mitochondrial fusion proteins MFN1 and MFN2, and reduces mitochondrial fusion activity, leading to mitochondrial fragmentation.
- The Drosophila retinoblastoma protein, Rbf1, induces a Debcl- and Drp1-dependent mitochondrial apoptosis
Highlighted Article: Debcl, a Drosophila pro-apoptotic Bcl-2 family member, can induce mitochondrial fragmentation by binding the pro-fission protein Drp1, which induces mitochondrial ROS accumulation, JNK pathway activation and cell death.