Nuclear pore complex
- Perforating the nuclear boundary – how nuclear pore complexes assemble
Summary: Nuclear pore complexes are the gatekeepers of the nuclear envelope. We summarize how these huge structures assemble from about a thousand individual proteins and integrate into the nuclear envelope.
- High resolution microscopy reveals the nuclear shape of budding yeast during cell cycle and in various biological states
Summary: This novel method to explore 3D geometry of the nuclear envelope with enhanced resolution and post-acquisition correction of z-axis aberration revealed increased NPC density near the SPB and the nucleolus.
- ELYS regulates the localization of LBR by modulating its phosphorylation state
Highlighted Article: The nuclear envelope localization of LBR is regulated through a phosphorylation network governed by ELYS, and defects in this phosphorylation network induce the aberrant phosphorylation and mislocalization of LBR.
- The LINC and NPC relationship – it's complicated!
Summary: In this Commentary, we review for the first time, the functional associations of two integral members of the nuclear envelope, namely the linkers of the nucleoskeleton and cytoskeleton, and nuclear pore complexes.
- Transmembrane protein TMEM170A is a newly discovered regulator of ER and nuclear envelope morphogenesis in human cells
Highlighted Article: TMEM170A is a human ER and nuclear envelope transmembrane protein. Down- and overexpression induce tubular or sheet ER formation, respectively, indicating that TMEM170A is a newly discovered ER-sheet-promoting protein.
- Nuclear size is sensitive to NTF2 protein levels in a manner dependent on Ran binding
Summary: NTF2 reduces the diameter of the NPC, nuclear import of large cargos and nuclear size in a Ran-binding-dependent manner, in both Xenopus and mammalian cells.
- The lysine demethylase LSD1 is required for nuclear envelope formation at the end of mitosis
Highlighted Article: Interfering with lysine demethylase LSD1 function severely affects nuclear envelope and pore complex reformation at the end of mitosis, indicating that changes on the chromatin landscape regulate these processes.