Planar cell polarity

  • RESEARCH ARTICLE
    PTK7 localization and protein stability is affected by canonical Wnt ligands
    Hanna Berger, Marlen Breuer, Hanna Peradziryi, Martina Podleschny, Ralf Jacob, Annette Borchers
    J Cell Sci 2017 130: 1890-1903; doi: 10.1242/jcs.198580

    Summary: In the presence of canonical Wnt proteins, the regulator of planar cell polarity PTK7 is endocytosed and degraded in lysosomes. By contrast, PTK7 inhibits canonical Wnt signaling suggesting a mechanism of mutual inhibition.

  • CELL SCIENCE AT A GLANCE
    Development and dynamics of cell polarity at a glance
    Joseph P. Campanale, Thomas Y. Sun, Denise J. Montell
    J Cell Sci 2017 130: 1201-1207; doi: 10.1242/jcs.188599

    Summary: Cell- and tissue-polarity protein complexes are modular and generate diverse types of polarity, including epithelial, migratory and stem cell polarities, and contribute to cell fate specification.

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