Planar cell polarity
- PTK7 localization and protein stability is affected by canonical Wnt ligands
Summary: In the presence of canonical Wnt proteins, the regulator of planar cell polarity PTK7 is endocytosed and degraded in lysosomes. By contrast, PTK7 inhibits canonical Wnt signaling suggesting a mechanism of mutual inhibition.
- Development and dynamics of cell polarity at a glance
Summary: Cell- and tissue-polarity protein complexes are modular and generate diverse types of polarity, including epithelial, migratory and stem cell polarities, and contribute to cell fate specification.