- Cancer cell behaviors mediated by dysregulated pH dynamics at a glance
Summary: Cancer cells have dysregulated pH dynamics and the increased intracellular pH enables a variety of cancer cell behaviors.
- Bradykinin promotes neuron-generating division of neural progenitor cells through ERK activation
Highlighted Article: Bradykinin induces neuron-generating division in vitro and in vivo, lengthening the G1 phase of the cell cycle and TIS21 expression. Neurogenesis through kinin-B2 receptor signaling was dependent on sustained ERK activation.
- Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland
Highlighted Article: SCRIB has been identified as a negative regulator of proliferation. However, SCRIB is also required for epithelial proliferation during pregnancy-induced alveologenesis, likely by regulating cell surface levels of prolactin receptor.
- RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells
Highlighted Article: RhoC maintains vascular homeostasis in endothelial cells yet is dispensable for vascular development. Inhibition of RhoC represents an attractive therapeutic approach to prevent cancer metastasis.