- EPAC1 activation by cAMP stabilizes CFTR at the membrane by promoting its interaction with NHERF1
Summary: Activation of the cAMP sensor EPAC1 leads to stabilization of CFTR at the plasma membrane, through a mechanism that involves the PDZ adaptor NHERF1, and could be used to increase the rescue of mutant CFTR.
- Reverse overshot water-wheel retroendocytosis of apotransferrin extrudes cellular iron
Summary: We present evidence that retroendocytosis of apotransferrin mediated by multifunctional GAPDH extrudes excess cellular Fe in a mechanism reminiscent of pumping out of water by a reverse overshot water-wheel.
- Photoreceptors at a glance
Summary: Rod and cone photoreceptors contain a unique light-sensitive outer segment compartment that has a central role in phototransduction, the visual cycle, membrane renewal, protein trafficking and many retinal degenerative diseases.
- α-Arrestins participate in cargo selection for both clathrin-independent and clathrin-mediated endocytosis
Summary: In yeast, α-arrestins bind the Rho1 GTPase and regulate internalization of selective cargo through the clathrin-independent endocytic pathway.