Wound healing
- Novel role for Grainy head in the regulation of cytoskeletal and junctional dynamics during epithelial repair
Highlighted Article: The transcription factor Grainy head is involved in tissue repair, through ensuring the formation of a proper contractile actomyosin cable and the regulation of adherens junction dynamics.
- The fibronectin ED-A domain enhances recruitment of latent TGF-β-binding protein-1 to the fibroblast matrix
Highlighted Article: The presence of the ED-A splice domain enhances the ability of fibronectin to bind latent pro-fibrotic TGF-β1 and thus supports activation of myofibroblasts, which are main drivers of fibrosis.
- The deubiquitylase USP10 regulates integrin β1 and β5 and fibrotic wound healing
Highlighted Article: The deubiquitylase USP10 regulates αv integrin protein levels, fibrotic markers and myofibroblast persistence in a wound. Ubiquitin-mediated pathways should thus be considered in the pathogenesis of fibrotic healing.
- IKKα regulates human keratinocyte migration through surveillance of the redox environment
Summary: This study provides a newly identified mechanism by which H2O2-dependent oxidation of the inhibitor of κB kinase α and de-repression of epidermal growth factor promoter activity stimulates keratinocyte migration.
- Hic-5 is required for myofibroblast differentiation by regulating mechanically dependent MRTF-A nuclear accumulation
Summary: The focal adhesion protein Hic-5 plays a crucial role in myofibroblast differentiation in response to TGF-β by facilitating tension-dependent stress fiber assembly and MRTF-A nuclear accumulation.