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Journal Article
The p120 catenin family: complex roles in adhesion, signaling and cancer
P.Z. Anastasiadis, A.B. Reynolds
Journal of Cell Science 2000 113: 1319-1334;

Summary

p120 catenin (p120) is the prototypic member of a growing subfamily of Armadillo-domain proteins found at cell-cell junctions and in nuclei. In contrast to the functions of the classical catenins (alpha-catenin, beta-catenin, and gamma-catenin/plakoglobin), which have been studied extensively, the first clues to p120's biological function have only recently emerged, and its role remains controversial. Nonetheless, it is now clear that p120 affects cell-cell adhesion through its interaction with the highly conserved juxtamembrane domain of classical cadherins, and is likely to have additional roles in the nucleus. Here, we summarize the data on the potential involvement of p120 both in promotion of and in prevension of adhesion, and propose models that attempt to reconcile some of the disparities in the literature. We also discuss the structural relationships and functions of several known p120 family members, as well as the potential roles of p120 in signaling and cancer.

REFERENCES

    1. Adams, C. L.,
    2. Nelson, W. J. and
    3. Smith, S. J.
    (1996). Quantitative analysis of cadherin-catenin-actin reorganization during development of cell-cell adhesion. J. Cell Biol 135, 1899–1911
    OpenUrlAbstract/FREE Full Text
    1. Adams, C. L.,
    2. Chen, Y. T.,
    3. Smith, S. J. and
    4. Nelson, W. J.
    (1998). Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein. J. Cell Biol 142, 1105–1119
    OpenUrlAbstract/FREE Full Text
    1. Aho, S.,
    2. Rothenberger, K. and
    3. Uitto, J.
    (1999). Human p120ctn catenin: tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen. J. Cell Biochem 73, 390–399
    OpenUrlCrossRefPubMed
    1. Albagli, O.,
    2. Dhordain, P.,
    3. Deweindt, C.,
    4. Lecocq, G. and
    5. Leprince, D.
    (1995). The BTB/POZ domain: a new protein-protein interaction motif common to DNA-and actin-binding proteins. Cell Growth Differ 6, 1193–1198
    OpenUrlAbstract
    1. Amagai, M.,
    2. Fujimori, T.,
    3. Masunaga, T.,
    4. Shimizu, H.,
    5. Nishikawa, T.,
    6. Shimizu, N.,
    7. Takeichi, M. and
    8. Hashimoto, T.
    (1995). Delayed assembly of desmosomes in keratinocytes with disrupted classic-cadherin-mediated cell adhesion by a dominant negative mutant. J. Invest. Dermatol 104, 27–32
    OpenUrlCrossRefPubMedWeb of Science
    1. Aono, S.,
    2. Nakagawa, S.,
    3. Reynolds, A. B. and
    4. Takeichi, M.
    (1999). p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells. J. Cell Biol 145, 551–562
    OpenUrlAbstract/FREE Full Text
    1. Balsamo, J.,
    2. Arregui, C.,
    3. Pathre, P. and
    4. Lilien, J.
    (1999). Coordinated regulation of N-cadherin and beta1-Integrin function by shuttling of the non-receptor protein tyrosine kinase Fer. Mol. Biol. Cell 10, 353–.
    OpenUrl
    1. Bardwell, V. J. and
    2. Treisman, R.
    (1994). The POZ domain: a conserved protein-protein interaction motif. Genes Dev 8, 1664–1677
    OpenUrlAbstract/FREE Full Text
    1. Barth, A. I.,
    2. Pollack, A. L.,
    3. Altschuler, Y.,
    4. Mostov, K. E. and
    5. Nelson, W. J.
    (1997). NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion. J. Cell Biol 136, 693–706
    OpenUrlAbstract/FREE Full Text
    1. Behrens, J.,
    2. von Kries, J. P.,
    3. Kuhl, M.,
    4. Bruhn, L.,
    5. Wedlich, D.,
    6. Grosschedl, R. and
    7. Birchmeier, W.
    (1996). Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 382, 638–642
    OpenUrlCrossRefPubMedWeb of Science
    1. Ben-Ze'ev, A. and
    2. Geiger, B.
    (1998). Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancer. Curr. Opin. Cell Biol 10, 629–639
    OpenUrlCrossRefPubMedWeb of Science
    1. Bonne, S.,
    2. Van Hengel, J. and
    3. van Roy, F.
    (1998). Chromosomal mapping of human armadillo genes belonging to the p120(ctn)/plakophilin subfamily. Genomics 51, 452–454
    OpenUrlCrossRefPubMedWeb of Science
    1. Bonne, S.,
    2. Van Hengel, J.,
    3. Nollet, F.,
    4. Kools, P. and
    5. van Roy, F.
    (1999). Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells. J. Cell Sci 112, 2265–2276
    OpenUrlAbstract/FREE Full Text
    1. Braga, V. M.,
    2. Machesky, L. M.,
    3. Hall, A. and
    4. Hotchin, N. A.
    (1997). The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J. Cell Biol 137, 1421–1431
    OpenUrlAbstract/FREE Full Text
    1. Braga, V. M.,
    2. Del Maschio, A.,
    3. Machesky, L. and
    4. Dejana, E.
    (1999). Regulation of cadherin function by Rho and Rac: modulation by junction maturation and cellular context. Mol. Biol. Cell 10, 9–22
    OpenUrlAbstract/FREE Full Text
    1. Calautti, E.,
    2. Cabodi, S.,
    3. Stein, P. L.,
    4. Hatzfeld, M.,
    5. Kedersha, N. and
    6. Paolo Dotto, G.
    (1998). Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion. J. Cell Biol 141, 1449–1465
    OpenUrlAbstract/FREE Full Text
    1. Chen, H.,
    2. Paradies, N. E.,
    3. Fedor-Chaiken, M. and
    4. Brackenbury, R.
    (1997). E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms. J. Cell Sci 110, 345–356
    OpenUrlAbstract/FREE Full Text
    1. Daniel, J. M. and
    2. Reynolds, A. B.
    (1995). The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin. Mol. Cell. Biol 15, 4819–4824
    OpenUrlAbstract/FREE Full Text
    1. Daniel, J. M. and
    2. Reynolds, A. B.
    (1997). Tyrosine phosphorylation and cadherin/catenin function. BioEssays 19, 883–891
    OpenUrlCrossRefPubMedWeb of Science
    1. Daniel, J. M. and
    2. Reynolds, A. B.
    (1999). The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Mol. Cell Biol 19, 3614–3623
    OpenUrlAbstract/FREE Full Text
    1. David, G.,
    2. Alland, L.,
    3. Hong, S. H.,
    4. Wong, C. W.,
    5. DePinho, R. A. and
    6. Dejean, A.
    (1998). Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein. Oncogene 16, 2549–2556
    OpenUrlCrossRefPubMedWeb of Science
    1. Dillon, D. A.,
    2. D'Aquila, T.,
    3. Reynolds, A. B.,
    4. Fearon, E. R. and
    5. Rimm, D. L.
    (1998). The expression of p120ctn protein in breast cancer is independent of alpha-and beta-catenin and E-cadherin. Am. J. Pathol 152, 75–82
    OpenUrlPubMedWeb of Science
    1. Downing, J. R. and
    2. Reynolds, A. B.
    (1991). PDGF, CSF-1 and EGF induce tyrosine phosphorylation of p120, a pp60src transformation-associated substrate. Oncogene 6, 607–613
    OpenUrlPubMedWeb of Science
    1. Esser, S.,
    2. Lampugnani, M. G.,
    3. Corada, M.,
    4. Dejana, E. and
    5. Risau, W.
    (1998). Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells. J. Cell Sci 111, 1853–1865
    OpenUrlAbstract/FREE Full Text
    1. Fanning, A. S. and
    2. Anderson, J. M.
    (1999). PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane. J. Clin. Invest 103, 767–772
    OpenUrlCrossRefPubMedWeb of Science
    1. Faull, R. J. and
    2. Ginsberg, M. H.
    (1996). Inside-out signaling through integrins. J. Am. Soc. Nephrol 7, 1091–1097
    OpenUrlAbstract
    1. Finnemann, S.,
    2. Mitrik, I.,
    3. Hess, M.,
    4. Otto, G. and
    5. Wedlich, D.
    (1997). Uncoupling of XB/U-cadherin-catenin complex formation from its function in cell-cell adhesion. J. Biol. Chem 272, 11856–11862
    OpenUrlAbstract/FREE Full Text
    1. Fujimori, T. and
    2. Takeichi, M.
    (1993). Disruption of epithelial cell-cell adhesion by exogenous expression of a mutated nonfunctional N-cadherin. Mol. Biol. Cell 4, 37–47
    OpenUrlAbstract/FREE Full Text
    1. Gold, J. S.,
    2. Reynolds, A. B. and
    3. Rimm, D. L.
    (1998). Loss of p120ctn in human colorectal cancer predicts metastasis and poor survival. Cancer Lett 132, 193–201
    OpenUrlCrossRefPubMedWeb of Science
    1. Grignani, F.,
    2. DeMatteis, S.,
    3. Nervi, C.,
    4. Tomassoni, L.,
    5. Gelmetti, V.,
    6. Cioce, M.,
    7. Fanelli, M.,
    8. Ruthardt, M.,
    9. Ferrara, F. F.,
    10. Zamir, I.,
    11. Seiser, C.,
    12. Lazar, M. A.,
    13. Minucci, S. and
    14. Pelicci, P. G.
    (1998). Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia. Nature 391, 815–818
    OpenUrlCrossRefPubMedWeb of Science
    1. Hatzfeld, M.,
    2. Kristjansson, G. I.,
    3. Plessmann, U. and
    4. Weber, K.
    (1994). Band 6 protein, a major constituent of desmosomes from stratified epithelia, is a novel member of the armadillo multigene family. J. Cell Sci 107, 2259–2270
    OpenUrlAbstract/FREE Full Text
    1. Hatzfeld, M. and
    2. Nachtsheim, C.
    (1996). Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins. J. Cell Sci 109, 2767–2778
    OpenUrlAbstract/FREE Full Text
    1. Heid, H. W.,
    2. Schmidt, A.,
    3. Zimbelmann, R.,
    4. Schafer, S.,
    5. Winter-Simanowski, S.,
    6. Stumpp, S.,
    7. Keith, M.,
    8. Figge, U.,
    9. Schnolzer, M. and
    10. Franke, W. W.
    (1994). Cell type-specific desmosomal plaque proteins of the plakoglobin family: plakophilin 1 (band 6 protein). Differentiation 58, 113–131
    OpenUrlCrossRefPubMedWeb of Science
    1. Herrenknecht, K.,
    2. Ozawa, M.,
    3. Eckerskorn, C.,
    4. Lottspeich, F.,
    5. Lenter, M. and
    6. Kemler, R.
    (1991). The uvomorulin-anchorage protein alpha catenin is a vinculin homologue. Proc. Nat. Acad. Sci. USA 88, 9156–9160
    OpenUrlAbstract/FREE Full Text
    1. Huber, A. H.,
    2. Nelson, W. J. and
    3. Weis, W. I.
    (1997). Three-dimensional structure of the armadillo repeat region of beta-catenin. Cell 90, 871–882
    OpenUrlCrossRefPubMedWeb of Science
    1. Huber, O.,
    2. Kemler, R. and
    3. Langosch, D.
    (1999). Mutations affecting transmembrane segment interactions impair adhesiveness of E-cadherin. J. Cell Sci 112, 4415–4423
    OpenUrlAbstract/FREE Full Text
    1. Ide, N.,
    2. Hata, Y.,
    3. Deguchi, M.,
    4. Hirao, K.,
    5. Yao, I. and
    6. Takai, Y.
    (1999). Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin. Biochem. Biophys. Res. Commun 256, 456–461
    OpenUrlCrossRefPubMedWeb of Science
    1. Imamura, H.,
    2. Takaishi, K.,
    3. Nakano, K.,
    4. Kodama, A.,
    5. Oishi, H.,
    6. Shiozaki, H.,
    7. Monden, M.,
    8. Sasaki, T. and
    9. Takai, Y.
    (1998). Rho and Rab small G proteins coordinately reorganize stress fibers and focal adhesions in MDCK cells. Mol. Biol. Cell 9, 2561–2575
    OpenUrlAbstract/FREE Full Text
    1. Jalink, K.,
    2. van Corven, E. J.,
    3. Hengeveld, T.,
    4. Morii, N.,
    5. Narumiya, S. and
    6. Moolenaar, W. H.
    (1994). Inhibition of lysophosphatidate-and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho. J. Cell Biol 126, 801–810
    OpenUrlAbstract/FREE Full Text
    1. Jawhari, A. U.,
    2. Noda, M.,
    3. Pignatelli, M. and
    4. Farthing, M.
    (1999). Up-regulated cytoplasmic expression, with reduced membranous distribution, of the src substrate p120(ctn) in gastric carcinoma. J. Pathol 189, 180–185
    OpenUrlCrossRefPubMedWeb of Science
    1. Jou, T. S. and
    2. Nelson, W. J.
    (1998). Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity. J. Cell Biol 142, 85–100
    OpenUrlAbstract/FREE Full Text
    1. Katz, B. Z.,
    2. Levenberg, S.,
    3. Yamada, K. M. and
    4. Geiger, B.
    (1998). Modulation of cell-cell adherens junctions by surface clustering of the N-cadherin cytoplasmic tail. Exp. Cell Res 243, 415–424
    OpenUrlCrossRefPubMedWeb of Science
    1. Kawanishi, J.,
    2. Kato, J.,
    3. Sasaki, K.,
    4. Fujii, S.,
    5. Watanabe, N. and
    6. Niitsu, Y.
    (1995). Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line, HSC-39. Mol. Cell. Biol 15, 1175–1181
    OpenUrlAbstract/FREE Full Text
    1. Keirsebilck, A.,
    2. Bonne, S.,
    3. Staes, K.,
    4. Van Hengel, J.,
    5. Nollet, F.,
    6. Reynolds, A. and
    7. van Roy, F.
    (1998). Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms. Genomics 50, 129–146
    OpenUrlCrossRefPubMedWeb of Science
    1. Kim, L. and
    2. Wong, T. W.
    (1995). The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors. Mol. Cell. Biol 15, 4553–4561
    OpenUrlAbstract/FREE Full Text
    1. Kinch, M. S.,
    2. Clark, G. J.,
    3. Der, C. J. and
    4. Burridge, K.
    (1995). Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia. J. Cell Biol 130, 461–471
    OpenUrlAbstract/FREE Full Text
    1. Kinch, M. S.,
    2. Petch, L.,
    3. Zhong, C. and
    4. Burridge, K.
    (1997). E-cadherinengagement stimulates tyrosine phosphorylation. Cell Adhes. Commun 4, 425–437
    OpenUrlCrossRefPubMed
    1. Kintner, C.
    (1992). Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain. Cell 69, 225–236
    OpenUrlCrossRefPubMedWeb of Science
    1. Klymkowsky, M. W.
    (1999). Plakophilin, armadillo repeats and nuclear localization. Microsc. Res. Tech 45, 43–54
    OpenUrlCrossRefPubMed
    1. Knudsen, K. A.,
    2. Soler, A. P.,
    3. Johnson, K. R. and
    4. Wheelock, M. J.
    (1995). Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin. J. Cell Biol 130, 67–77
    OpenUrlAbstract/FREE Full Text
    1. Kodama, A.,
    2. Takaishi, K.,
    3. Nakano, K.,
    4. Nishioka, H. and
    5. Takai, Y.
    (1999). Involvement of Cdc42 small G protein in cell-cell adhesion, migration and morphology of MDCK cells. Oncogene 18, 3996–4006
    OpenUrlCrossRefPubMedWeb of Science
    1. Kolanus, W. and
    2. Zeitlmann, L.
    (1998). Regulation of integrin function by inside-out signaling mechanisms. Curr. Top. Microbiol. Immunol 231, 33–49
    OpenUrlPubMedWeb of Science
    1. Korinek, V.,
    2. Barker, N.,
    3. Morin, P. J.,
    4. van Wichen, D.,
    5. de Weger, R.,
    6. Kinzler, K. W.,
    7. Vogelstein, B. and
    8. Clevers, H.
    (1997). Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC/ colon carcinoma. Science 275, 1784–1787
    OpenUrlAbstract/FREE Full Text
    1. Kotani, H.,
    2. Takaishi, K.,
    3. Sasaki, T. and
    4. Takai, Y.
    (1997). Rho regulates association of both the ERM family and vinculin with the plasma membrane in MDCK cells. Oncogene 14, 1705–1713
    OpenUrlCrossRefPubMedWeb of Science
    1. Kowalczyk, A. P.,
    2. Hatzfeld, M.,
    3. Bornslaeger, E. A.,
    4. Kopp, D. S.,
    5. Borgwardt, J. E.,
    6. Corcoran, C. M.,
    7. Settler, A. and
    8. Green, K. J.
    (1999). The head domain of plakophilin-1 binds to desmoplakin and enhances its recruitment to desmosomes. Implications for cutaneous disease. J. Biol. Chem 274, 18145–18148
    OpenUrlAbstract/FREE Full Text
    1. Kranenburg, O.,
    2. Poland, M.,
    3. van Horck, F. P.,
    4. Drechsel, D.,
    5. Hall, A. and
    6. Moolenaar, W. H.
    (1999). Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: induction of neurite retraction. Mol. Biol. Cell 10, 1851–1857
    OpenUrlAbstract/FREE Full Text
    1. Kusumi, A.,
    2. Suzuki, K. and
    3. Koyasako, K.
    (1999). Mobility and cytoskeletal interactions of cell adhesion receptors. Curr. Opin. Cell Biol 11, 582–590
    OpenUrlCrossRefPubMedWeb of Science
    1. Lampugnani, M. G.,
    2. Corada, M.,
    3. Andriopoulou, P.,
    4. Esser, S.,
    5. Risau, W. and
    6. Dejana, E.
    (1997). Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells. J. Cell Sci 110, 2065–2077
    OpenUrlAbstract/FREE Full Text
    1. Levesque, G.,
    2. Yu, G.,
    3. Nishimura, M.,
    4. Zhang, D. M.,
    5. Levesque, L.,
    6. Yu, H.,
    7. Xu, D.,
    8. Liang, Y.,
    9. Rogaeva, E.,
    10. Ikeda, M.,
    11. Duthie, M.,
    12. Murgolo, N.,
    13. Wang, L.,
    14. VanderVere, P.,
    15. Bayne, M. L.,
    16. Strader, C. D.,
    17. Rommens, J. M.,
    18. Fraser, P. E. and
    19. St. George-Hyslop, P.
    (1999). Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin. J. Neurochem 72, 999–1008
    OpenUrlCrossRefPubMedWeb of Science
    1. Lilien, J.,
    2. Arregui, C.,
    3. Li, H. and
    4. Balsamo, J.
    (1999). The juxtamembrane domain of cadherin regulates integrin-mediated adhesion and neurite outgrowth. J. Neurosci. Res 58, 727–734
    OpenUrlCrossRefPubMedWeb of Science
    1. Lin, R. J.,
    2. Nagy, L.,
    3. Inoue, S.,
    4. Shao, W.,
    5. Miller, W. H. Jr.. and
    6. Evans, R. M.
    (1998). Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature 391, 811–814
    OpenUrlCrossRefPubMedWeb of Science
    1. Lu, Q.,
    2. Paredes, M.,
    3. Medina, M.,
    4. Zhou, J.,
    5. Cavallo, R.,
    6. Peifer, M.,
    7. Orecchio, L. and
    8. Kosik, K. S.
    (1999). delta-catenin, an adhesive junction-associated protein which promotes cell scattering. J. Cell Biol 144, 519–532
    OpenUrlAbstract/FREE Full Text
    1. Mariner, D. J.,
    2. Wang, J. and
    3. Reynolds, A. B.
    (2000). ARVCF localizes to the nucleus and adherens junction and is mutually exclusive with p120ctn in E-cadherin complexes. J. Cell Sci 113, 1481–1490
    OpenUrlAbstract/FREE Full Text
    1. Mertens, C.,
    2. Kuhn, C. and
    3. Franke, W. W.
    (1996). Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque. J. Cell Biol 135, 1009–1025
    OpenUrlAbstract/FREE Full Text
    1. Mo, Y. Y. and
    2. Reynolds, A. B.
    (1996). Identification of murine p120 isoforms and heterogeneous expression of p120cas isoforms in human tumor cell lines. Cancer Res 56, 2633–2640
    OpenUrlAbstract/FREE Full Text
    1. Molenaar, M.,
    2. van de Wetering, M.,
    3. Oosterwegel, M.,
    4. Peterson-Maduro, J.,
    5. Godsave, S.,
    6. Korinek, V.,
    7. Roose, J.,
    8. Destree, O. and
    9. Clevers, H.
    (1996). XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. Cell 86, 391–399
    OpenUrlCrossRefPubMedWeb of Science
    1. Morin, P. J.,
    2. Sparks, A. B.,
    3. Korinek, V.,
    4. Barker, N.,
    5. Clevers, H.,
    6. Vogelstein, B. and
    7. Kinzler, K. W.
    (1997). Activation of-catenin-TCF signaling in colon cancer by mutations in -catenin or APC. Science 275, 1787–1790
    OpenUrlAbstract/FREE Full Text
    1. Munemitsu, S.,
    2. Albert, I.,
    3. Souza, B.,
    4. Rubinfeld, B. and
    5. Polakis, P.
    (1995). Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc. Nat. Acad. Sci. USA 92, 3046–3050
    OpenUrlAbstract/FREE Full Text
    1. Nagafuchi, A. and
    2. Takeichi, M.
    (1989). Transmembrane control of cadherin-mediated cell adhesion: a 94 kDa protein functionally associated with a specific region of the cytoplasmic domain of E-cadherin. Cell Regul 1, 37–44
    OpenUrlPubMedWeb of Science
    1. Nagafuchi, A.,
    2. Takeichi, M. and
    3. Tsukita, S.
    (1991). The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression. Cell 65, 849–857
    OpenUrlCrossRefPubMedWeb of Science
    1. Nagar, B.,
    2. Overduin, M.,
    3. Ikura, M. and
    4. Rini, J. M.
    (1996). Structural basis of calcium-induced E-cadherin rigidification and dimerization. Nature 380, 360–364
    OpenUrlCrossRefPubMedWeb of Science
    1. Nathke, I. S.,
    2. Hinck, L.,
    3. Swedlow, J. R.,
    4. Papkoff, J. and
    5. Nelson, W. J.
    (1994). Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells. J. Cell Biol 125, 1341–1352
    OpenUrlAbstract/FREE Full Text
    1. Navarro, P.,
    2. Caveda, L.,
    3. Breviario, F.,
    4. Mandoteanu, I.,
    5. Lampugnani, M. G. and
    6. Dejana, E.
    (1995). Catenin-dependent and-independent functions of vascular endothelial cadherin. J. Biol. Chem 270, 30965–30972
    OpenUrlAbstract/FREE Full Text
    1. Navarro, P.,
    2. Ruco, L. and
    3. Dejana, E.
    (1998). Differential localization of VE-and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization. J. Cell Biol 140, 1475–1484
    OpenUrlAbstract/FREE Full Text
    1. Nieman, M. T.,
    2. Kim, J. B.,
    3. Johnson, K. R. and
    4. Wheelock, M. J.
    (1999). Mechanism of extracellular domain-deleted dominant negative cadherins. J. Cell Sci 112, 1621–1632
    OpenUrlAbstract/FREE Full Text
    1. Nieset, J. E.,
    2. Redfield, A. R.,
    3. Jin, F.,
    4. Knudsen, K. A.,
    5. Johnson, K. R. and
    6. Wheelock, M. J.
    (1997). Characterization of the interactions of alpha-catenin with alpha-actinin and beta-catenin/plakoglobin. J. Cell Sci 110, 1013–1022
    OpenUrlAbstract/FREE Full Text
    1. Nishimura, M.,
    2. Yu, G. and
    3. St George-Hyslop, P. H.
    ) (1999). Biology of presenilins as causative molecules for Alzheimer disease. Clin. Genet 55, 219–225
    OpenUrlCrossRefPubMedWeb of Science
    1. Ohkubo, T. and
    2. Ozawa, M.
    (1999). p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity. J. Biol. Chem 274, 21409–21415
    OpenUrlAbstract/FREE Full Text
    1. Ozawa, M.,
    2. Ringwald, M. and
    3. Kemler, R.
    (1990). Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule. Proc. Nat. Acad. Sci. USA 87, 4246–4250
    OpenUrlAbstract/FREE Full Text
    1. Ozawa, M. and
    2. Kemler, R.
    (1998). The membrane-proximal region of the E-cadherin cytoplasmic domain prevents dimerization and negatively regulates adhesion activity. J. Cell Biol 142, 1605–1613
    OpenUrlAbstract/FREE Full Text
    1. Paffenholz, R. and
    2. Franke, W. W.
    (1997). Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family. Differentiation 61, 293–304
    OpenUrlCrossRefPubMedWeb of Science
    1. Paffenholz, R.,
    2. Kuhn, C.,
    3. Grund, C.,
    4. Stehr, S. and
    5. Franke, W. W.
    (1999). The arm-repeat protein NPRAP (neurojungin) is a constituent of the plaques of the outer limiting zone in the retina, defining a novel type of adhering junction. Exp. Cell Res 250, 452–464
    OpenUrlCrossRefPubMedWeb of Science
    1. Papkoff, J.
    (1997). Regulation of complexed and free catenin pools by distinct mechanisms. Differential effects of Wnt-1 and v-Src. J. Biol. Chem 272, 4536–4543
    OpenUrlAbstract/FREE Full Text
    1. Paulson, A. F.,
    2. Fang, X.,
    3. Ji, H.,
    4. Reynolds, A. B. and
    5. McCrea, P. D.
    (1999). Misexpression of the catenin p120(ctn)1A perturbs Xenopus gastrulation but does not elicit Wnt-directed axis specification. Dev. Biol 207, 350–363
    OpenUrlCrossRefPubMed
    1. Peifer, M.,
    2. Berg, S. and
    3. Reynolds, A. B.
    (1994). A repeating amino acid motif shared by proteins with diverse cellular roles. Cell 76, 789–791
    OpenUrlCrossRefPubMedWeb of Science
    1. Perl, A. K.,
    2. Wilgenbus, P.,
    3. Dahl, U.,
    4. Semb, H. and
    5. Christofori, G.
    (1998). A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 392, 190–193
    OpenUrlCrossRefPubMedWeb of Science
    1. Pertz, O.,
    2. Bozic, D.,
    3. Koch, A. W.,
    4. Fauser, C.,
    5. Brancaccio, A. and
    6. Engel, J.
    (1999). A new crystal structure, Ca2+ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation. EMBO J 18, 1738–1747
    OpenUrlAbstract
    1. Powell, S. M.,
    2. Zilz, N.,
    3. Beazer-Barclay, Y.,
    4. Bryan, T. M.,
    5. Hamilton, S. R.,
    6. Thibodeau, S. N.,
    7. Vogelstein, B. and
    8. Kinzler, K. W.
    (1992). APC mutations occur early during colorectal tumorigenesis. Nature 359, 235–237
    OpenUrlCrossRefPubMedWeb of Science
    1. Ratcliffe, M. J.,
    2. Rubin, L. L. and
    3. Staddon, J. M.
    (1997). Dephosphorylation of the cadherin-associated p100/p120 proteins in response to activation of protein kinase C in epithelial cells. J. Biol. Chem 272, 31894–31901
    OpenUrlAbstract/FREE Full Text
    1. Ratcliffe, M. J.,
    2. Smales, C. and
    3. Staddon, J. M.
    (1999). Dephosphorylation of the catenins p120 and p100 in endothelial cells in response to inflammatory stimuli. Biochem. J 338, 471–478
    OpenUrlAbstract/FREE Full Text
    1. Reynolds, A. B.,
    2. Roesel, D. J.,
    3. Kanner, S. B. and
    4. Parsons, J. T.
    (1989). Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene. Mol. Cell. Biol 9, 629–638
    OpenUrlAbstract/FREE Full Text
    1. Reynolds, A. B.,
    2. Herbert, L.,
    3. Cleveland, J. L.,
    4. Berg, S. T. and
    5. Gaut, J. R.
    (1992). p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo. Oncogene 7, 2439–2445
    OpenUrlPubMedWeb of Science
    1. Reynolds, A. B.,
    2. Daniel, J.,
    3. McCrea, P. D.,
    4. Wheelock, M. J.,
    5. Wu, J. and
    6. Zhang, Z.
    (1994). Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes. Mol. Cell. Biol 14, 8333–8342
    OpenUrlAbstract/FREE Full Text
    1. Reynolds, A. B.,
    2. Daniel, J. M.,
    3. Mo, Y. Y.,
    4. Wu, J. and
    5. Zhang, Z.
    (1996). The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts. Exp. Cell Res 225, 328–337
    OpenUrlCrossRefPubMedWeb of Science
    1. Riehl, R.,
    2. Johnson, K.,
    3. Bradley, R.,
    4. Grunwald, G. B.,
    5. Cornel, E.,
    6. Lilienbaum, A. and
    7. Holt, C. E.
    (1996). Cadherin function is required for axon outgrowth in retinal ganglion cells in vivo. Neuron 17, 837–848
    OpenUrlCrossRefPubMedWeb of Science
    1. Rimm, D. L.,
    2. Koslov, E. R.,
    3. Kebriaei, P.,
    4. Cianci, C. D. and
    5. Morrow, J. S.
    (1995). Alpha 1(E)-catenin is an actin-binding and-bundling protein mediating the attachment of F-actin to the membrane adhesion complex. Proc. Nat. Acad. Sci. USA 92, 8813–8817
    OpenUrlAbstract/FREE Full Text
    1. Rosato, R.,
    2. Veltmaat, J. M.,
    3. Groffen, J. and
    4. Heisterkamp, N.
    (1998). Involvement of the tyrosine kinase fer in cell adhesion. Mol. Cell Biol 18, 5762–5770
    OpenUrlAbstract/FREE Full Text
    1. Rubinfeld, B.,
    2. Souza, B.,
    3. Albert, I.,
    4. Muller, O.,
    5. Chamberlain, S. H.,
    6. Masiarz, F. R.,
    7. Munemitsu, S. and
    8. Polakis, P.
    (1993). Association of the APC gene product with beta-catenin. Science 262, 1731–1734
    OpenUrlAbstract/FREE Full Text
    1. Rubinfeld, B.,
    2. Robbins, P.,
    3. El-Gamil, M.,
    4. Albert, I.,
    5. Porfiri, E. and
    6. Polakis, P.
    (1997). Stabilization of beta-catenin by genetic defects in melanoma cell lines. Science 275, 1790–1792
    OpenUrlAbstract/FREE Full Text
    1. Saffell, J. L.,
    2. Williams, E. J.,
    3. Mason, I. J.,
    4. Walsh, F. S. and
    5. Doherty, P.
    (1997). Expression of a dominant negative FGF receptor inhibits axonal growth and FGF receptor phosphorylation stimulated by CAMs. Neuron 18, 231–242
    OpenUrlCrossRefPubMedWeb of Science
    1. Sakai, R.,
    2. Iwamatsu, A.,
    3. Hirano, N.,
    4. Ogawa, S.,
    5. Tanaka, T.,
    6. Mano, H.,
    7. Yazaki, Y. and
    8. Hirai, H.
    (1994). A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J 13, 3748–3756
    OpenUrlPubMedWeb of Science
    1. Schmidt, A.,
    2. Langbein, L.,
    3. Rode, M.,
    4. Pratzel, S.,
    5. Zimbelmann, R. and
    6. Franke, W. W.
    (1997). Plakophilins 1a and 1b: widespread nuclear proteins recruited in specific epithelial cells as desmosomal plaque components. Cell Tissue Res 290, 481–499
    OpenUrlCrossRefPubMedWeb of Science
    1. Schmidt, A.,
    2. Langbein, L.,
    3. Pratzel, S.,
    4. Rode, M.,
    5. Rackwitz, H. R. and
    6. Franke, W. W.
    (1999). Plakophilin 3—a novel cell-type-specific desmosomal plaque protein. Differentiation 64, 291–306
    OpenUrlCrossRefPubMedWeb of Science
    1. Shapiro, L.,
    2. Fannon, A. M.,
    3. Kwong, P. D.,
    4. Thompson, A.,
    5. Lehmann, M. S.,
    6. Grubel, G.,
    7. Legrand, J. F.,
    8. Als-Nielsen, J.,
    9. Colman, D. R. and
    10. Hendrickson, W. A.
    (1995). Structural basis of cell-cell adhesion by cadherins. Nature 374, 327–337
    OpenUrlCrossRefPubMedWeb of Science
    1. Shibamoto, S.,
    2. Hayakawa, M.,
    3. Takeuchi, K.,
    4. Hori, T.,
    5. Miyazawa, K.,
    6. Kitamura, N.,
    7. Johnson, K. R.,
    8. Wheelock, M. J.,
    9. Matsuyoshi, N. and
    10. Takeichi, M.
    (1995). Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes. J. Cell Biol 128, 949–957
    OpenUrlAbstract/FREE Full Text
    1. Shimazui, T.,
    2. Schalken, J. A.,
    3. Giroldi, L. A.,
    4. Jansen, C. F.,
    5. Akaza, H.,
    6. Koiso, K.,
    7. Debruyne, F. M. and
    8. Bringuier, P. P.
    (1996). Prognostic value of cadherin-associated molecules (alpha-, beta-and gamma-catenins and p120cas) in bladder tumors. Cancer Res 56, 4154–4158
    OpenUrlAbstract/FREE Full Text
    1. Sirotkin, H.,
    2. O'Donnell, H.,
    3. DasGupta, R.,
    4. Halford, S.,
    5. St. Jore, B.,
    6. Puech, A.,
    7. Parimoo, S.,
    8. Morrow, B.,
    9. Skoultchi, A.,
    10. Weissman, S. M.,
    11. Scambler, P. and
    12. Kucherlapati, R.
    (1997). Identification of a new human catenin gene family member (ARVCF) from the region deleted in velo-cardio-facial syndrome. Genomics 41, 75–83
    OpenUrlCrossRefPubMedWeb of Science
    1. Skoudy, A.,
    2. Gomez, S.,
    3. Fabre, M. and
    4. Garcia de Herreros, A.
    (1996). p120-catenin expression in human colorectal cancer. Int. J. Cancer 68, 14–20
    OpenUrlCrossRefPubMedWeb of Science
    1. Skoudy, A.,
    2. Llosas, M. D. and
    3. Garcia de Herreros, A.
    (1996). Intestinal HT-29 cells with dysfunction of E-cadherin show increased pp60src activity and tyrosine phosphorylation of p120-catenin. Biochem. J 317, 279–284
    OpenUrlAbstract/FREE Full Text
    1. Smith, E. A. and
    2. Fuchs, E.
    (1998). Defining the interactions between intermediate filaments and desmosomes. J. Cell Biol 141, 1229–1241
    OpenUrlAbstract/FREE Full Text
    1. Staddon, J. M.,
    2. Smales, C.,
    3. Schulze, C.,
    4. Esch, F. S. and
    5. Rubin, L. L.
    (1995). p120, a p120-related protein (p100), and the cadherin/catenin complex. J. Cell Biol 130, 369–381
    OpenUrlAbstract/FREE Full Text
    1. Stahl, B.,
    2. Diehlmann, A. and
    3. Sudhof, T. C.
    (1999). Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071. J. Biol. Chem 274, 9141–9148
    OpenUrlAbstract/FREE Full Text
    1. Stappert, J. and
    2. Kemler, R.
    (1994). A short core region of E-cadherin is essential for catenin binding and is highly phosphorylated. Cell Adh. Commun 2, 319–327
    OpenUrlCrossRefPubMedWeb of Science
    1. Su, L. K.,
    2. Vogelstein, B. and
    3. Kinzler, K. W.
    (1993). Association of the APC tumor suppressor protein with catenins. Science 262, 1734–1737
    OpenUrlAbstract/FREE Full Text
    1. Syrigos, K. N.,
    2. Karayiannakis, A.,
    3. Syrigou, E. I.,
    4. Harrington, K. and
    5. Pignatelli, M.
    (1998). Abnormal expression of p120 correlates with poor survival in patients with bladder cancer. Eur. J. Cancer 34, 2037–2040
    OpenUrlCrossRefPubMedWeb of Science
    1. Takaishi, K.,
    2. Sasaki, T.,
    3. Kameyama, T.,
    4. Tsukita, S. and
    5. Takai, Y.
    (1995). Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows. Oncogene 11, 39–48
    OpenUrlPubMedWeb of Science
    1. Takaishi, K.,
    2. Sasaki, T.,
    3. Kotani, H.,
    4. Nishioka, H. and
    5. Takai, Y.
    (1997). Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J. Cell Biol 139, 1047–1059
    OpenUrlAbstract/FREE Full Text
    1. Takeichi, M.
    (1995). Morphogenetic roles of classic cadherins. Curr. Opin. Cell Biol 7, 619–627
    OpenUrlCrossRefPubMedWeb of Science
    1. Tamura, K.,
    2. Shan, W. S.,
    3. Hendrickson, W. A.,
    4. Colman, D. R. and
    5. Shapiro, L.
    (1998). Structure-function analysis of cell adhesion by neural (N-) cadherin. Neuron 20, 1153–1163
    OpenUrlCrossRefPubMedWeb of Science
    1. Tanahashi, H. and
    2. Tabira, T.
    (1999). Isolation of human delta-catenin and its binding specificity with presenilin 1. Neuroreport 10, 563–568
    OpenUrlCrossRefPubMedWeb of Science
    1. Thoreson, M. A.,
    2. Anastasiadis, P. Z.,
    3. Daniel, J. M.,
    4. Ireton, R. C.,
    5. Wheelock, M. J.,
    6. Johnson, K. R.,
    7. Hummingbird, D. K. and
    8. Reynolds, A. B.
    (2000). Selective uncoupling of p120ctn from E-cadherin disrupts strong adhesion. J. Cell Biol 148, 189–201
    OpenUrlAbstract/FREE Full Text
    1. Tozer, E. C.,
    2. Hughes, P. E. and
    3. Loftus, J. C.
    (1996). Ligand binding and affinity modulation of integrins. Biochem. Cell Biol 74, 785–798
    OpenUrlCrossRefPubMedWeb of Science
    1. Troxell, M. L.,
    2. Chen, Y. T.,
    3. Cobb, N.,
    4. Nelson, W. J. and
    5. Marrs, J. A.
    (1999). Cadherin function in junctional complex rearrangement and posttranslational control of cadherin expression. Am. J. Physiol 276, 404–18
    OpenUrl
    1. Troyanovsky, S. M.
    (1999). Mechanism of cell-cell adhesion complex assembly. Curr. Opin. Cell Biol 11, 561–566
    OpenUrlCrossRefPubMedWeb of Science
    1. Valizadeh, A.,
    2. Karayiannakis, A. J.,
    3. el-Hariry, I.,
    4. Kmiot, W. and
    5. Pignatelli, M.
    (1997). Expression of E-cadherin-associated molecules (alpha-, beta-, and gamma-catenins and p120) in colorectal polyps. Am. J. Pathol 150, 1977–1984
    OpenUrlPubMedWeb of Science
    1. Van de Wetering, M.,
    2. Cavallo, R.,
    3. Dooijes, D.,
    4. van Beest, M.,
    5. van Es, J.,
    6. Loureiro, J.,
    7. Ypma, A.,
    8. Hursh, D.,
    9. Jones, T.,
    10. Bejsovec, A.,
    11. Peifer, M.,
    12. Mortin, M. and
    13. Clevers, H.
    (1997). Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell 88, 789–799
    OpenUrlCrossRefPubMedWeb of Science
    1. Van Hengel, J.,
    2. Vanhoenacker, P.,
    3. Staes, K. and
    4. van Roy, F.
    (1999). Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression. Proc. Nat. Acad. Sci. USA 96, 7980–7985
    OpenUrlAbstract/FREE Full Text
    1. Watabe, M.,
    2. Nagafuchi, A.,
    3. Tsukita, S. and
    4. Takeichi, M.
    (1994). Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line. J. Cell Biol 127, 247–256
    OpenUrlAbstract/FREE Full Text
    1. Wu, J.,
    2. Mariner, D. J.,
    3. Thoreson, M. A. and
    4. Reynolds, A. B.
    (1998). Production and characterization of monoclonal antibodies to the catenin p120ctn. Hybridoma 17, 175–183
    OpenUrlCrossRefPubMed
    1. Yap, A. S.
    (1998). The morphogenetic role of cadherin cell adhesion molecules in human cancer: a thematic review. Cancer Invest 16, 252–261
    OpenUrlCrossRefPubMedWeb of Science
    1. Yap, A. S.,
    2. Niessen, C. M. and
    3. Gumbiner, B. M.
    (1998). The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn. J. Cell Biol 141, 779–789
    OpenUrlAbstract/FREE Full Text
    1. Zhong, C.,
    2. Kinch, M. S. and
    3. Burridge, K.
    (1997). Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells. Mol. Biol. Cell 8, 2329–2344
    OpenUrlAbstract/FREE Full Text
    1. Zhou, J.,
    2. Liyanage, U.,
    3. Medina, M.,
    4. Ho, C.,
    5. Simmons, A. D.,
    6. Lovett, M. and
    7. Kosik, K. S.
    (1997). Presenilin 1 interaction in the brain with a novel member of the Armadillo family. Neuroreport 8, 2085–2090
    OpenUrlCrossRefPubMedWeb of Science
    1. Zhu, A. J. and
    2. Watt, F. M.
    (1996). Expression of a dominant negative cadherin mutant inhibits proliferation and stimulates terminal differentiation of human epidermal keratinocytes. J. Cell Sci 109, 3013–3023
    OpenUrlAbstract/FREE Full Text
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Journal Article
The p120 catenin family: complex roles in adhesion, signaling and cancer
P.Z. Anastasiadis, A.B. Reynolds
Journal of Cell Science 2000 113: 1319-1334;
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