Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Accepted manuscripts
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Special issues
    • Subject collections
    • Cell Scientists to Watch
    • First Person
    • Sign up for alerts
  • About us
    • About JCS
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Fast-track manuscripts
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • JCS Prize
    • Manuscript transfer network
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contacts
    • Contact JCS
    • Subscriptions
    • Advertising
    • Feedback
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

User menu

  • Log in

Search

  • Advanced search
Journal of Cell Science
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

supporting biologistsinspiring biology

Journal of Cell Science

  • Log in
Advanced search

RSS   Twitter  Facebook   YouTube  

  • Home
  • Articles
    • Accepted manuscripts
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Special issues
    • Subject collections
    • Cell Scientists to Watch
    • First Person
    • Sign up for alerts
  • About us
    • About JCS
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Fast-track manuscripts
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • JCS Prize
    • Manuscript transfer network
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contacts
    • Contact JCS
    • Subscriptions
    • Advertising
    • Feedback
Commentary
Elastic fibres
Cay M. Kielty, Michael J. Sherratt, C. Adrian Shuttleworth
Journal of Cell Science 2002 115: 2817-2828;
Cay M. Kielty
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael J. Sherratt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C. Adrian Shuttleworth
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & tables
  • Info & metrics
  • PDF
Loading

Article Figures & Tables

Figures

  •   Fig. 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig. 1.

    Transmission electron microscopy of fibrillin-rich microfibrils and elastic fibres. (A) Human ciliary zonular microfibrils in loose, roughly parallel arrays. (B) Lobster aorta microfibrils, showing periodic striations. (C) Deposition of microfibrils and elastin by cultured bovine nuchal ligament fibroblasts. (D) Close-up of elastic fibres forming in bovine nuchal ligament fibroblast cultures. (E) Internal elastic lamina (IEL) of murine aorta, with associated endothelial cell (EC) and smooth muscle cell (SMC).

  •   Fig. 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig. 2.

    Microfibril and elastic fibre formation. Fibrillin is assembled pericellularly into microfibrillar arrays that appear to undergo time-dependent maturation into beaded transglutaminase-crosslinked microfibrils. Mature microfibrils form parallel bundles that may be stabilised at inter-microfibrillar crosslinked regions. In elastic tissues, tropoelastin is deposited on microfibril bundles, and lysyl oxidase-derived crosslinks then stabilise the elastin core. Crosslinks catalysed by the actions of transglutaminase and lysyl oxidase are shown. Transglutaminase formsγ -glutamyl-e-lysine isopeptide bonds within or between peptide chains. Lysyl oxidase catalyses the oxidative deamination of certain lysine residues in elastin and subsequent, probably spontaneous, reactions lead to the formation of bifunctional crosslinks (dehydrolysinonorleucine and allysine aldol), a trifunctional crosslink (dehydromerodesmosine), and two tetrafunctional crosslinks (desmosine and isodesmosine, shown here).

  •   Fig. 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig. 3.

    Tapping mode atomic force microscopy (TMAFM) of isolated fibrillin-rich microfibrils on mica. (A) 1 μm×1 μm scan of beaded microfibrils isolated from fetal bovine nuchal ligament. (B,C) 180 nm×80 nm extracted region of three beaded repeats (C shows height contour map). (D) 3D height contour profile of the three beaded repeat units.

  • Table 1.

    Reported microfibril and elastic fibre associated molecules

    MoleculeChromosomeLocationReferences
    Fibrillin-115q21.1Microfibrils Pereira et al., 1993; Baldock et al., 2001
    Fibrillin-25q23-q31Microfibrils Zhang et al., 1994
    Fibrillin-319p? Microfibrils Nagase et al., 2001
    MAGP-11pter — 1qterMicrofibrils Brown-Augsberger et al., 1996
    MAGP-212p13.1-p12.3Some microfibrils Gibson et al., 1998
    LTBP-12p12-q22Some microfibrils Miyazono et al., 1988; Sinha et al., 1998
    LTBP-214q22-q33Microfibrils/elastic fibres Gibson et al., 1995; Bashir et al., 1996
    LTBP-311q12? Yin et al., 1995
    LTBP-419q13.1? Giltay et al., 1997
    Decorin12q13.2Microfibrils Trask et al., 2000a
    BiglycanXq28Elastic fibre core Reinboth et al., 2001
    Versican5q12-q14Some microfibrils Isogai et al., 2002
    MFAP-115q15-q21Some microfibrils Liu et al., 1997
    MFAP-35q32-q32.2Some microfibrils Abrams et al., 1995
    MFAP-4 (MAGP-36)17p11.2Some microfibrils Lausen et al., 1999; Hirano et al., 2002
    Tropoelastin7q11.2Elastic fibre core Mecham and Davis, 1994
    Lysyl oxidase (LOX)5q23.3-q31.2Microfibrils/tropoelastin Csiszar, 2001
    LOXL8p21.3-p21.2? Borel et al., 2001
    LOXL215q22? Csiszar, 2001
    LOXL32p13? Csiszar, 2001
    BigH3 (keratoepithelin)5q31Elastic fibre/collagen interface Gibson et al., 1997
    Fibulin-122q13.3Elastic fibre core Kostka et al., 2001
    Fibulin-23p24-25Elastin-microfibril interface Tsuda et al., 2001
    Fibulin-514q32.1Elastic fibre—cell interface Nakamura et al., 2002; Yanagisawa et al., 2002
    Emilin-12p23Elastin-microfibril interface Doliana et al., 1999
    Emilin-218p11.3Elastin-microfibril interface Doliana et al., 2001
    Elastin-binding protein3p21.33Newly secreted tropoelastin Prody et al., 1998
    Vitronectin17q11Some microfibrils Dählback et al., 1990
    AmyloidSome microfibrils Dählback et al., 1990
    Collagen VIII [α1(VIII)]3q12-q13.1Some elastic fibres Sadawa and Konomi, 1991
    Collagen XVI [α1(XVI)]1p34Dermal microfibrils Grässel et al., 1999
    Endostatin [α1(XVIII)]21q22.3Vascular elastic fibres Miosge et al., 1999
    Collagen VISome microfibrils Finnis and Gibson, 1997
    [α1(VI) α2(VI)]21q22.3
    [α3(VI)]2q37
  •   Fig. 4.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig. 4.

    Domain structures of fibrillin-1 and elastin, showing molecular interaction sites identified in vitro (see Molecular Interactions). (A) Fibrillin-1 has 47 cbEGF-like domains, interspersed with TB modules. A proline-rich region is towards the N-terminus. N-glycosylation sites are indicated. (B) Elastin contains alternating hydrophobic and crosslinking domains. The C-terminus has two cysteines and a negatively charged pocket.

Previous ArticleNext Article
Back to top
Previous ArticleNext Article

This Issue

 Download PDF

Email

Thank you for your interest in spreading the word on Journal of Cell Science.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Elastic fibres
(Your Name) has sent you a message from Journal of Cell Science
(Your Name) thought you would like to see the Journal of Cell Science web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Commentary
Elastic fibres
Cay M. Kielty, Michael J. Sherratt, C. Adrian Shuttleworth
Journal of Cell Science 2002 115: 2817-2828;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Commentary
Elastic fibres
Cay M. Kielty, Michael J. Sherratt, C. Adrian Shuttleworth
Journal of Cell Science 2002 115: 2817-2828;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Alerts

Please log in to add an alert for this article.

Sign in to email alerts with your email address

Article navigation

  • Top
  • Article
    • Summary
    • Introduction
    • Elastic fibre organisation
    • Molecular complexity
    • Molecular interactions
    • Assembly
    • Mouse models
    • Acknowledgements
    • References
  • Figures & tables
  • Info & metrics
  • PDF

Related articles

Cited by...

More in this TOC section

  • Lamins in the nuclear interior − life outside the lamina
  • Molecular mechanisms of kinesin-14 motors in spindle assembly and chromosome segregation
  • Mechanisms of regulation and diversification of deubiquitylating enzyme function
Show more Commentary

Similar articles

Other journals from The Company of Biologists

Development

Journal of Experimental Biology

Disease Models & Mechanisms

Biology Open

Advertisement

2020 at The Company of Biologists

Despite the challenges of 2020, we were able to bring a number of long-term projects and new ventures to fruition. While we look forward to a new year, join us as we reflect on the triumphs of the last 12 months.


Mole – The Corona Files

"This is not going to go away, 'like a miracle.' We have to do magic. And I know we can."

Mole continues to offer his wise words to researchers on how to manage during the COVID-19 pandemic.


Cell scientist to watch – Christine Faulkner

In an interview, Christine Faulkner talks about where her interest in plant science began, how she found the transition between Australia and the UK, and shares her thoughts on virtual conferences.


Read & Publish participation extends worldwide

“The clear advantages are rapid and efficient exposure and easy access to my article around the world. I believe it is great to have this publishing option in fast-growing fields in biomedical research.”

Dr Jaceques Behmoaras (Imperial College London) shares his experience of publishing Open Access as part of our growing Read & Publish initiative. We now have over 60 institutions in 12 countries taking part – find out more and view our full list of participating institutions.


JCS and COVID-19

For more information on measures Journal of Cell Science is taking to support the community during the COVID-19 pandemic, please see here.

If you have any questions or concerns, please do not hestiate to contact the Editorial Office.

Articles

  • Accepted manuscripts
  • Latest complete issue
  • Issue archive
  • Archive by article type
  • Special issues
  • Subject collections
  • Interviews
  • Sign up for alerts

About us

  • About Journal of Cell Science
  • Editors and Board
  • Editor biographies
  • Travelling Fellowships
  • Grants and funding
  • Journal Meetings
  • Workshops
  • The Company of Biologists

For Authors

  • Submit a manuscript
  • Aims and scope
  • Presubmission enquiries
  • Fast-track manuscripts
  • Article types
  • Manuscript preparation
  • Cover suggestions
  • Editorial process
  • Promoting your paper
  • Open Access
  • JCS Prize
  • Manuscript transfer network
  • Biology Open transfer

Journal Info

  • Journal policies
  • Rights and permissions
  • Media policies
  • Reviewer guide
  • Sign up for alerts

Contacts

  • Contact JCS
  • Subscriptions
  • Advertising
  • Feedback

Twitter   YouTube   LinkedIn

© 2021   The Company of Biologists Ltd   Registered Charity 277992