Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Special issues
    • Subject collections
    • Cell Scientists to Watch
    • First Person
    • Sign up for alerts
  • About us
    • About JCS
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Fast-track manuscripts
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • JCS Prize
    • Manuscript transfer network
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contacts
    • Contact JCS
    • Subscriptions
    • Advertising
    • Feedback
    • For library administrators
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

User menu

  • Log in

Search

  • Advanced search
Journal of Cell Science
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

supporting biologistsinspiring biology

Journal of Cell Science

  • Log in
Advanced search

RSS   Twitter  Facebook   YouTube  

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Special issues
    • Subject collections
    • Cell Scientists to Watch
    • First Person
    • Sign up for alerts
  • About us
    • About JCS
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Fast-track manuscripts
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • JCS Prize
    • Manuscript transfer network
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contacts
    • Contact JCS
    • Subscriptions
    • Advertising
    • Feedback
    • For library administrators
Research Article
Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat
J. Samuel Zigler, Jr, Cheng Zhang, Rhonda Grebe, Gitanjali Sehrawat, Laszlo Hackler, Jr, Souvonik Adhya, Stacey Hose, D. Scott McLeod, Imran Bhutto, Walid Barbour, Geetha Parthasarathy, Donald J. Zack, Yuri Sergeev, Gerard A. Lutty, James T. Handa, Debasish Sinha
Journal of Cell Science 2011 124: 523-531; doi: 10.1242/jcs.078790
J. Samuel Zigler Jr
1The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cheng Zhang
1The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rhonda Grebe
1The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gitanjali Sehrawat
1The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Laszlo Hackler Jr
1The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Souvonik Adhya
1The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stacey Hose
1The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D. Scott McLeod
1The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Imran Bhutto
1The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Walid Barbour
1The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Geetha Parthasarathy
1The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Donald J. Zack
1The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yuri Sergeev
2National Eye Institute, National Institutes of Health, 31 Center Drive, MSC 2510, Bethesda, MD 20892-2510, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gerard A. Lutty
1The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James T. Handa
1The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Debasish Sinha
1The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: Debasish@jhmi.edu
  • Article
  • Figures & tables
  • Supp info
  • Info & metrics
  • PDF
Loading

Article Information

vol. 124 no. 4, 523-531

DOI 
https://doi.org/10.1242/jcs.078790
PubMed 
21266465

Published By 
The Company of Biologists Ltd
Print ISSN 
0021-9533
Online ISSN 
1477-9137
History 
  • Accepted October 26, 2010
  • Published online January 31, 2011.
Posted online 
January 25, 2011
Copyright & Usage 
© 2011.

Article Versions

  • Previous version (January 25, 2011 - 05:15).
  • You are viewing the most recent version of this article.

Author Information

  1. J. Samuel Zigler Jr1,
  2. Cheng Zhang1,
  3. Rhonda Grebe1,
  4. Gitanjali Sehrawat1,
  5. Laszlo Hackler Jr1,
  6. Souvonik Adhya1,
  7. Stacey Hose1,
  8. D. Scott McLeod1,
  9. Imran Bhutto1,
  10. Walid Barbour1,
  11. Geetha Parthasarathy1,
  12. Donald J. Zack1,
  13. Yuri Sergeev2,
  14. Gerard A. Lutty1,
  15. James T. Handa1 and
  16. Debasish Sinha1,*
  1. 1The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
  2. 2National Eye Institute, National Institutes of Health, 31 Center Drive, MSC 2510, Bethesda, MD 20892-2510, USA
  1. ↵* Author for correspondence (Debasish{at}jhmi.edu)

Article usage

Usage statistics are calculated at the beginning of each month for the previous month.

Usage statistics: January 2011 to February 2021

AbstractFullPdf
Jan 2011271664
Feb 2011908990
Mar 2011361948
Apr 2011272318
May 2011461716
Jun 2011663518
Jul 2011701816
Aug 2011624616
Sep 2011393924
Oct 2011564334
Nov 2011522515
Dec 2011392223
Total 2011610392382
Jan 2012512325
Feb 2012531927
Mar 2012331720
Apr 2012372021
May 2012331722
Jun 2012341614
Jul 2012321515
Aug 2012342023
Sep 2012331421
Oct 2012341120
Nov 2012211625
Dec 201230821
Total 2012425196254
Jan 2013371616
Feb 2013371110
Mar 201332910
Apr 2013491113
May 2013531417
Jun 201319159
Jul 201314813
Aug 201312413
Sep 2013171720
Oct 2013171414
Nov 2013131316
Dec 201317512
Total 2013317137163
Jan 2014221126
Feb 201413820
Mar 2014243119
Apr 20145715
May 201416713
Jun 201413910
Jul 2014271917
Aug 201410209
Sep 201411188
Oct 2014135215
Nov 2014208711
Dec 20149234
Total 2014183292167
Jan 20159127
Feb 201522714
Mar 20151559
Apr 201512129
May 201524119
Jun 201512410
Jul 201516817
Aug 2015161119
Sep 2015302024
Oct 2015151623
Nov 201562713
Dec 201511214
Total 2015188154158
Jan 2016102524
Feb 2016112113
Mar 201671428
Apr 201692017
May 201662120
Jun 201674724
Jul 2016177414
Aug 2016122415
Sep 201642712
Oct 2016112919
Nov 2016172710
Dec 20164209
Total 2016115349205
Jan 201744614
Feb 201703311
Mar 20174437
Apr 20175248
May 20175233
Jun 20172295
Jul 20172156
Aug 201731813
Sep 201732912
Oct 20176249
Nov 201733014
Dec 201712610
Total 201738340112
Jan 201802610
Feb 20189204
Mar 20182309
Apr 20181252
May 201825613
Jun 201863811
Jul 201873420
Aug 20180255
Sep 20182372
Oct 201822810
Nov 20184156
Dec 2018415213
Total 201839486105
Jan 2019414310
Feb 201922917
Mar 201982718
Apr 201932711
May 2019103217
Jun 201921616
Jul 20193198
Aug 20190179
Sep 20190153
Oct 20190103
Nov 201921510
Dec 20193176
Total 201937367128
Jan 202022616
Feb 202001512
Mar 20200162
Apr 20201114
May 202012217
Jun 20201177
Jul 2020087
Aug 20202115
Sep 2020493
Oct 202001813
Nov 20202379
Dec 202081818
Total 202021208113
Jan 202121012
Feb 202121615
Total 202142627
Total197729471814

Statistics from Altmetric.com

Previous ArticleNext Article
Back to top
Previous ArticleNext Article

This Issue

Keywords

  • βA3/A1-crystallin
  • Cathepsin D
  • Retinal pigmented epithelium (RPE)
  • Photoreceptor outer segment discs
  • Lysosome
  • Phagocytosis
  • Autophagy

 Download PDF

Email

Thank you for your interest in spreading the word on Journal of Cell Science.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat
(Your Name) has sent you a message from Journal of Cell Science
(Your Name) thought you would like to see the Journal of Cell Science web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Research Article
Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat
J. Samuel Zigler, Jr, Cheng Zhang, Rhonda Grebe, Gitanjali Sehrawat, Laszlo Hackler, Jr, Souvonik Adhya, Stacey Hose, D. Scott McLeod, Imran Bhutto, Walid Barbour, Geetha Parthasarathy, Donald J. Zack, Yuri Sergeev, Gerard A. Lutty, James T. Handa, Debasish Sinha
Journal of Cell Science 2011 124: 523-531; doi: 10.1242/jcs.078790
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Research Article
Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat
J. Samuel Zigler, Jr, Cheng Zhang, Rhonda Grebe, Gitanjali Sehrawat, Laszlo Hackler, Jr, Souvonik Adhya, Stacey Hose, D. Scott McLeod, Imran Bhutto, Walid Barbour, Geetha Parthasarathy, Donald J. Zack, Yuri Sergeev, Gerard A. Lutty, James T. Handa, Debasish Sinha
Journal of Cell Science 2011 124: 523-531; doi: 10.1242/jcs.078790

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Alerts

Please log in to add an alert for this article.

Sign in to email alerts with your email address

Article navigation

  • Top
  • Article
    • Summary
    • Introduction
    • Results
    • Discussion
    • Materials and Methods
    • Acknowledgements
    • Footnotes
    • References
  • Figures & tables
  • Supp info
  • Info & metrics
  • PDF

Related articles

Cited by...

More in this TOC section

  • Orbit/CLASP determines centriole length by antagonising Klp10A in Drosophila spermatocytes
  • DNAJB chaperones suppress destabilised protein aggregation via a region unique from that used to inhibit amyloidogenesis
  • Transcription co-factor LBH is necessary for survival of cochlear hair cells
Show more Research Articles

Similar articles

Other journals from The Company of Biologists

Development

Journal of Experimental Biology

Disease Models & Mechanisms

Biology Open

Advertisement

Cell scientist to watch: Janet Iwasa

Read our interview with molecular animator Janet Iwasa, where she talks about her transition from the wet lab, explains how animation can facilitate research and discusses the challenges of the field.


New funding scheme supports sustainable events

As part of our Sustainable Conferencing Initiative, we are pleased to announce funding for organisers that seek to reduce the environmental footprint of their event. The next deadline to apply for a Scientific Meeting grant is 26 March 2021.


Mole – The Corona files

“Despite everything, it's just incredible that we get to do science.”

Mole continues to offer his wise words to researchers on how to manage during the COVID-19 pandemic.


JCS and COVID-19

For more information on measures Journal of Cell Science is taking to support the community during the COVID-19 pandemic, please see here.

If you have any questions or concerns, please do not hestiate to contact the Editorial Office.

Articles

  • Accepted manuscripts
  • Issue in progress
  • Latest complete issue
  • Issue archive
  • Archive by article type
  • Special issues
  • Subject collections
  • Interviews
  • Sign up for alerts

About us

  • About Journal of Cell Science
  • Editors and Board
  • Editor biographies
  • Travelling Fellowships
  • Grants and funding
  • Journal Meetings
  • Workshops
  • The Company of Biologists

For Authors

  • Submit a manuscript
  • Aims and scope
  • Presubmission enquiries
  • Fast-track manuscripts
  • Article types
  • Manuscript preparation
  • Cover suggestions
  • Editorial process
  • Promoting your paper
  • Open Access
  • JCS Prize
  • Manuscript transfer network
  • Biology Open transfer

Journal Info

  • Journal policies
  • Rights and permissions
  • Media policies
  • Reviewer guide
  • Sign up for alerts

Contacts

  • Contact JCS
  • Subscriptions
  • Advertising
  • Feedback

Twitter   YouTube   LinkedIn

© 2021   The Company of Biologists Ltd   Registered Charity 277992