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Research Article
Non-muscle Mlck is required for β-catenin- and FoxO1-dependent downregulation of Cldn5 in IL-1β-mediated barrier dysfunction in brain endothelial cells
Richard S. Beard, Jr, Ricci J. Haines, Kevin Y. Wu, Jason J. Reynolds, Stephanie M. Davis, John E. Elliott, Nikolay L. Malinin, Victor Chatterjee, Byeong J. Cha, Mack H. Wu, Sarah Y. Yuan
Journal of Cell Science 2014 127: 1840-1853; doi: 10.1242/jcs.144550
Richard S. Beard Jr
1Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
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Ricci J. Haines
2Department of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
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Kevin Y. Wu
1Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
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Jason J. Reynolds
1Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
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Stephanie M. Davis
1Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
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John E. Elliott
1Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
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Nikolay L. Malinin
1Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
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Victor Chatterjee
1Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
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Byeong J. Cha
1Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
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Mack H. Wu
2Department of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
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Sarah Y. Yuan
1Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
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  • For correspondence: syuan@health.usf.edu
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Article Information

vol. 127 no. 8, 1840-1853

DOI 
https://doi.org/10.1242/jcs.144550
PubMed 
24522189

Published By 
The Company of Biologists Ltd
Print ISSN 
0021-9533
Online ISSN 
1477-9137
History 
  • Received October 11, 2013
  • Accepted January 12, 2014
  • Published online April 15, 2014.
Posted online 
February 12, 2014
Copyright & Usage 
© 2014. Published by The Company of Biologists Ltd

Article Versions

  • Previous version (February 12, 2014 - 05:47).
  • You are viewing the most recent version of this article.

Author Information

  1. Richard S. Beard Jr1,
  2. Ricci J. Haines2,
  3. Kevin Y. Wu1,
  4. Jason J. Reynolds1,
  5. Stephanie M. Davis1,
  6. John E. Elliott1,
  7. Nikolay L. Malinin1,
  8. Victor Chatterjee1,
  9. Byeong J. Cha1,
  10. Mack H. Wu2 and
  11. Sarah Y. Yuan1,*
  1. 1Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
  2. 2Department of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
  1. ↵*Author for correspondence (syuan{at}health.usf.edu)
View Abstract

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Feb 2014457174
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Jul 20203811
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Total 202045256364
Total260625672373

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Keywords

  • Non-muscle myosin light chain kinase
  • Claudin-5
  • Foxo1
  • IL-1β
  • β-catenin
  • Blood–brain barrier
  • Neuroinflammation

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Research Article
Non-muscle Mlck is required for β-catenin- and FoxO1-dependent downregulation of Cldn5 in IL-1β-mediated barrier dysfunction in brain endothelial cells
Richard S. Beard, Jr, Ricci J. Haines, Kevin Y. Wu, Jason J. Reynolds, Stephanie M. Davis, John E. Elliott, Nikolay L. Malinin, Victor Chatterjee, Byeong J. Cha, Mack H. Wu, Sarah Y. Yuan
Journal of Cell Science 2014 127: 1840-1853; doi: 10.1242/jcs.144550
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Research Article
Non-muscle Mlck is required for β-catenin- and FoxO1-dependent downregulation of Cldn5 in IL-1β-mediated barrier dysfunction in brain endothelial cells
Richard S. Beard, Jr, Ricci J. Haines, Kevin Y. Wu, Jason J. Reynolds, Stephanie M. Davis, John E. Elliott, Nikolay L. Malinin, Victor Chatterjee, Byeong J. Cha, Mack H. Wu, Sarah Y. Yuan
Journal of Cell Science 2014 127: 1840-1853; doi: 10.1242/jcs.144550

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