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Research Article
Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells
Takehiko Ueyama, Hirofumi Sakaguchi, Takashi Nakamura, Akihiro Goto, Shigefumi Morioka, Aya Shimizu, Kazuki Nakao, Yoshitaka Hishikawa, Yuzuru Ninoyu, Hidetoshi Kassai, Shiro Suetsugu, Takehiko Koji, Bernd Fritzsch, Shigenobu Yonemura, Yasuo Hisa, Michiyuki Matsuda, Atsu Aiba, Naoaki Saito
Journal of Cell Science 2014 127: 2040-2052; doi: 10.1242/jcs.143602
Takehiko Ueyama
1Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657-8501, Japan
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  • For correspondence: tueyama@kobe-u.ac.jp naosaito@kobe-u.ac.jp
Hirofumi Sakaguchi
2Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
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Takashi Nakamura
1Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657-8501, Japan
2Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
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Akihiro Goto
3Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University, Kyoto 606-8315, Japan
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Shigefumi Morioka
1Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657-8501, Japan
2Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
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Aya Shimizu
1Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657-8501, Japan
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Kazuki Nakao
4Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan
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Yoshitaka Hishikawa
5Division of Histochemistry and Cell Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan
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Yuzuru Ninoyu
1Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657-8501, Japan
2Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
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Hidetoshi Kassai
4Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan
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Shiro Suetsugu
6Laboratory of Membrane and Cytoskeleton Dynamics, Institute of Molecular and Cellular Biosciences, Univeristy of Tokyo, Tokyo 113-0032, Japan
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Takehiko Koji
7Department of Histology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan
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Bernd Fritzsch
8Department of Biology, College of Liberal Arts and Sciences, University of Iowa, Iowa, IA 52242, USA
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Shigenobu Yonemura
9Electron Microscope Laboratory, Center for Developmental Biology, RIKEN, Kobe 650-0047, Japan
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Yasuo Hisa
2Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
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Michiyuki Matsuda
3Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University, Kyoto 606-8315, Japan
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Atsu Aiba
4Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan
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Naoaki Saito
1Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657-8501, Japan
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  • For correspondence: tueyama@kobe-u.ac.jp naosaito@kobe-u.ac.jp
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Article Information

vol. 127 no. 9, 2040-2052

DOI 
https://doi.org/10.1242/jcs.143602
PubMed 
24610943

Published By 
The Company of Biologists Ltd
Print ISSN 
0021-9533
Online ISSN 
1477-9137
History 
  • Received September 30, 2013
  • Accepted January 22, 2014
  • Published online April 30, 2014.
Posted online 
March 07, 2014
Copyright & Usage 
© 2014. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Article Versions

  • Previous version (March 7, 2014 - 02:18).
  • Previous version (March 14, 2014 - 06:47).
  • You are viewing the most recent version of this article.

Author Information

  1. Takehiko Ueyama1,*,‡,
  2. Hirofumi Sakaguchi2,*,
  3. Takashi Nakamura1,2,
  4. Akihiro Goto3,
  5. Shigefumi Morioka1,2,
  6. Aya Shimizu1,
  7. Kazuki Nakao4,
  8. Yoshitaka Hishikawa5,
  9. Yuzuru Ninoyu1,2,
  10. Hidetoshi Kassai4,
  11. Shiro Suetsugu6,
  12. Takehiko Koji7,
  13. Bernd Fritzsch8,
  14. Shigenobu Yonemura9,
  15. Yasuo Hisa2,
  16. Michiyuki Matsuda3,
  17. Atsu Aiba4 and
  18. Naoaki Saito1,‡
  1. 1Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657-8501, Japan
  2. 2Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
  3. 3Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University, Kyoto 606-8315, Japan
  4. 4Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan
  5. 5Division of Histochemistry and Cell Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan
  6. 6Laboratory of Membrane and Cytoskeleton Dynamics, Institute of Molecular and Cellular Biosciences, Univeristy of Tokyo, Tokyo 113-0032, Japan
  7. 7Department of Histology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan
  8. 8Department of Biology, College of Liberal Arts and Sciences, University of Iowa, Iowa, IA 52242, USA
  9. 9Electron Microscope Laboratory, Center for Developmental Biology, RIKEN, Kobe 650-0047, Japan
  1. ↵‡Authors for correspondence (tueyama{at}kobe-u.ac.jp; naosaito{at}kobe-u.ac.jp)

Article usage

Usage statistics are calculated at the beginning of each month for the previous month.

Usage statistics: March 2014 to January 2021

AbstractFullPdf
Mar 20146110243
Apr 201441213255
May 2014715138163
Jun 20141868394
Jul 20141339138
Aug 2014435531
Sep 2014647030
Oct 2014634530
Nov 2014593038
Dec 2014655832
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Jan 2015507335
Feb 2015473921
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Apr 2015503720
May 2015272811
Jun 2015263935
Jul 2015262731
Aug 2015191726
Sep 2015203929
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Jan 2016145353
Feb 20161256145
Mar 201675932
Apr 201677531
May 2016265443
Jun 2016225742
Jul 2016217244
Aug 2016265429
Sep 201695928
Oct 2016197841
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Total 2016189729536
Jan 201795711
Feb 201726418
Mar 201764815
Apr 201757418
May 201726125
Jun 201716925
Jul 201725913
Aug 201745913
Sep 201705528
Oct 201706038
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Total 201741711263
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Apr 2018819440
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Jul 201849619
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Apr 201914824
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Feb 202065015
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May 202067119
Jun 202053617
Jul 202004221
Aug 202014118
Sep 202064018
Oct 202075816
Nov 202066348
Dec 202085622
Total 202048576242
Jan 202173327
Total 202173327
Total307257322964

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Keywords

  • Cdc42
  • Deafness
  • Stereocilia
  • Hair cell
  • Apical junctional complex
  • Actin turnover
  • FRET

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Research Article
Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells
Takehiko Ueyama, Hirofumi Sakaguchi, Takashi Nakamura, Akihiro Goto, Shigefumi Morioka, Aya Shimizu, Kazuki Nakao, Yoshitaka Hishikawa, Yuzuru Ninoyu, Hidetoshi Kassai, Shiro Suetsugu, Takehiko Koji, Bernd Fritzsch, Shigenobu Yonemura, Yasuo Hisa, Michiyuki Matsuda, Atsu Aiba, Naoaki Saito
Journal of Cell Science 2014 127: 2040-2052; doi: 10.1242/jcs.143602
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Research Article
Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells
Takehiko Ueyama, Hirofumi Sakaguchi, Takashi Nakamura, Akihiro Goto, Shigefumi Morioka, Aya Shimizu, Kazuki Nakao, Yoshitaka Hishikawa, Yuzuru Ninoyu, Hidetoshi Kassai, Shiro Suetsugu, Takehiko Koji, Bernd Fritzsch, Shigenobu Yonemura, Yasuo Hisa, Michiyuki Matsuda, Atsu Aiba, Naoaki Saito
Journal of Cell Science 2014 127: 2040-2052; doi: 10.1242/jcs.143602

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