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August, 2015; 128 (16)

IN THIS ISSUE

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    Rab39a hijacked by chlamydia
    Journal of Cell Science 2015 128: e1601
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    Prion protein slows down monocytes
    Journal of Cell Science 2015 128: e1602
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    A Trio for Rac1 at endothelial junctions
    Journal of Cell Science 2015 128: e1603
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    Rab23 helps Kif17 transport to the cilia
    Journal of Cell Science 2015 128: e1604
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    BUB1-mediated SAC activation in human cells
    Journal of Cell Science 2015 128: e1605

CELL SCIENTISTS TO WATCH

  • You have accessSubscription required
    Victoria Cowling
    Journal of Cell Science 2015 128: 2953-2954; doi: 10.1242/jcs.176693

OBITUARY

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    Guido Tarone, Ph.D. (1951–2015)
    Filippo G. Giancotti, Reinhard Fässler
    Journal of Cell Science 2015 128: 2955-2956; doi: 10.1242/jcs.175919

CELL SCIENCE AT A GLANCE

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    The Exocyst at a Glance
    Bin Wu, Wei Guo
    Journal of Cell Science 2015 128: 2957-2964; doi: 10.1242/jcs.156398

    Summary: The octameric exocyst complex is implicated in vesicle tethering during exocytosis. Recent works from different fields have revealed its role beyond membrane trafficking.

COMMENTARY

  • Open Access
    Tropomyosin – master regulator of actin filament function in the cytoskeleton
    Peter W. Gunning, Edna C. Hardeman, Pekka Lappalainen, Daniel P. Mulvihill
    Journal of Cell Science 2015 128: 2965-2974; doi: 10.1242/jcs.172502

    Summary: This Commentary explains how tropomyosin isoforms determine the function of individual actin filaments in the cytoskeleton, and their subsequent use in directing cell structure and function.

SHORT REPORTS

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    Dissecting the roles of human BUB1 in the spindle assembly checkpoint
    Mathijs Vleugel, Tim A. Hoek, Eelco Tromer, Tale Sliedrecht, Vincent Groenewold, Manja Omerzu, Geert J. P. L. Kops
    Journal of Cell Science 2015 128: 2975-2982; doi: 10.1242/jcs.169821

    Highlighted Article: BUB1 forms a platform for targeting spindle assembly checkpoint proteins to unattached kinetochores. It is shown here that the recruitment of CDC20 is crucial for the role of BUB1 in the spindle assembly checkpoint.

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    Endothelial MMP14 is required for endothelial-dependent growth support of human airway basal cells
    Bi-Sen Ding, Kazunori Gomi, Shahin Rafii, Ronald G. Crystal, Matthew S. Walters
    Journal of Cell Science 2015 128: 2983-2988; doi: 10.1242/jcs.168179

    Summary: Basal cell and endothelial cell crosstalk might play a substantial role in maintaining normal airway structure, with alteration of this crosstalk contributing towards smoking-dependent airway remodeling.

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    Contribution of NADPH oxidase to the establishment of hippocampal neuronal polarity in culture
    Carlos Wilson, M. Tulio Núñez, Christian González-Billault
    Journal of Cell Science 2015 128: 2989-2995; doi: 10.1242/jcs.168567

    Summary: NOX function is involved in the establishment of neuronal polarity.

RESEARCH ARTICLES

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    A role for Rab23 in the trafficking of Kif17 to the primary cilium
    Yi Shan Lim, Bor Luen Tang
    Journal of Cell Science 2015 128: 2996-3008; doi: 10.1242/jcs.163964

    Highlighted Article: The small GTPase Rab23 mediates the transport of the kinesin-2 motor Kif17 to the primary cilium by interacting with it and its adaptor importin β2.

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    Robust hematopoietic progenitor cell commitment in the presence of a conflicting cue
    Najaf A. Shah, Marshall J. Levesque, Arjun Raj, Casim A. Sarkar
    Journal of Cell Science 2015 128: 3009-3017; doi: 10.1242/jcs.158436

    Summary: Progenitor cells can make robust commitment decisions in the face of conflicting cues by modulating the expression levels of lineage-specific receptors.

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    The prion protein inhibits monocytic cell migration by stimulating β1 integrin adhesion and uropod formation
    Dion D. Richardson, Simon Tol, Eider Valle-Encinas, Cayetano Pleguezuelos, Ruben Bierings, Dirk Geerts, Mar Fernandez-Borja
    Journal of Cell Science 2015 128: 3018-3029; doi: 10.1242/jcs.165365

    Highlighted Article: PrP modulates β1 integrin adhesion and migration of monocytes through RhoA-induced actin remodeling mediated by cofilin and through the regulation of ERM-mediated membrane–cytoskeleton linkage.

  • Open Access
    RNA splicing regulated by RBFOX1 is essential for cardiac function in zebrafish
    Karen S. Frese, Benjamin Meder, Andreas Keller, Steffen Just, Jan Haas, Britta Vogel, Simon Fischer, Christina Backes, Mark Matzas, Doreen Köhler, Vladimir Benes, Hugo A. Katus, Wolfgang Rottbauer
    Journal of Cell Science 2015 128: 3030-3040; doi: 10.1242/jcs.166850

    Summary: The zebrafish splicing regulator rbfox1 is necessary for tightly regulated splicing and unconstrained cardiac function, making it an interesting candidate for targeting during human cardiomyopathy.

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    A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1
    Ilse Timmerman, Niels Heemskerk, Jeffrey Kroon, Antje Schaefer, Jos van Rijssel, Mark Hoogenboezem, Jakobus van Unen, Joachim Goedhart, Theodorus W. J. Gadella, Jr, Taofei Yin, Yi Wu, Stephan Huveneers, Jaap D. van Buul
    Journal of Cell Science 2015 128: 3041-3054; doi: 10.1242/jcs.168674

    Highlighted Article: The Rho-GEF Trio controls the stability of endothelial cell–cell junctions by locally activating the GTPase Rac1 at VE-cadherin-based junctions. Loss of Trio increases focal adherens junctions and electrical resistance.

  • Open Access
    The homeobox gene DLX4 regulates erythro-megakaryocytic differentiation by stimulating IL-1β and NF-κB signaling
    Bon Q. Trinh, Nicolas Barengo, Sang Bae Kim, Ju-Seog Lee, Patrick A. Zweidler-McKay, Honami Naora
    Journal of Cell Science 2015 128: 3055-3067; doi: 10.1242/jcs.168187

    Summary: The homeobox gene DLX4 promotes megakaryocyte development at the expense of erythroid generation by inducing IL-1 and NF-κB signaling.

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    The late endocytic Rab39a GTPase regulates the interaction between multivesicular bodies and chlamydial inclusions
    Julian Gambarte Tudela, Anahi Capmany, Maryse Romao, Cristian Quintero, Stephanie Miserey-Lenkei, Graca Raposo, Bruno Goud, Maria Teresa Damiani
    Journal of Cell Science 2015 128: 3068-3081; doi: 10.1242/jcs.170092

    Highlighted Article: Rab39a GTPase participates in the delivery of MVBs and host lipids to maturing chlamydial inclusions, thereby promoting inclusion growth and bacterial development.

  • Open Access
    Cezanne regulates E2F1-dependent HIF2α expression
    Sonia Moniz, Daniel Bandarra, John Biddlestone, Kirsteen J. Campbell, David Komander, Anja Bremm, Sonia Rocha
    Journal of Cell Science 2015 128: 3082-3093; doi: 10.1242/jcs.168864

    Summary: Cezanne regulates HIF2α levels and activity by modulating expression of the HIF2α gene through regulation of E2F1 protein levels. Cezanne depletion impairs normal cell cycle progression and increases cell death.

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    Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury
    Jayakumar Thangavel, Saheli Samanta, Sheeja Rajasingh, Bahar Barani, Yu-Ting Xuan, Buddhadeb Dawn, Johnson Rajasingh
    Journal of Cell Science 2015 128: 3094-3105; doi: 10.1242/jcs.170258

    Summary: Combinatorial treatment with Aza+TSA reduces inflammation and promotes an anti-inflammatory M2 macrophage phenotype in ALI, and has a therapeutic potential for patients with sepsis and ALI.

  • Open Access
    Paxillin-dependent regulation of IGF2 and H19 gene cluster expression
    Pavel Marášek, Rastislav Dzijak, Irina Studenyak, Jindřiška Fišerová, Lívia Uličná, Petr Novák, Pavel Hozák
    Journal of Cell Science 2015 128: 3106-3116; doi: 10.1242/jcs.170985

    Summary: A new regulatory pathway whereby paxillin mediates the expression of two growth-related genes, IGF2 and H19, is presented, uncovering a role for paxillin in cell proliferation.

  • Open Access
    Modulation of flagellum attachment zone protein FLAM3 and regulation of the cell shape in Trypanosoma brucei life cycle transitions
    Jack D. Sunter, Corinna Benz, Jane Andre, Sarah Whipple, Paul G. McKean, Keith Gull, Michael L. Ginger, Julius Lukeš
    Journal of Cell Science 2015 128: 3117-3130; doi: 10.1242/jcs.171645

    Summary: Trypanosoma brucei FLAM3 is a flagellar FAZ protein. Its depletion leads to a reduction in FAZ length, which has different consequences depending on the life cycle stage of the parasite.

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    Transport of the cholera toxin B-subunit from recycling endosomes to the Golgi requires clathrin and AP-1
    Tatsuyuki Matsudaira, Takahiro Niki, Tomohiko Taguchi, Hiroyuki Arai
    Journal of Cell Science 2015 128: 3131-3142; doi: 10.1242/jcs.172171

    Summary: Clathtin and AP-1 are required for the retrograde transport of cholera toxin from recycling endosomes to the Golgi complex.

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    A STIM1-dependent ‘trafficking trap’ mechanism regulates Orai1 plasma membrane residence and Ca2+ influx levels
    Rawad Hodeify, Senthil Selvaraj, Jennifer Wen, Abdelilah Arredouani, Satanay Hubrack, Maya Dib, Sara N. Al-Thani, Timothy McGraw, Khaled Machaca
    Journal of Cell Science 2015 128: 3143-3154; doi: 10.1242/jcs.172320

    Summary: Intracellular Orai1 trafficking to the plasma membrane in response to Ca2+ store depletion modulates store-operated Ca2+ entry influx through a ‘trafficking trap’ mechanism that depends on STIM1 expression levels.

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    An unconventional calmodulin-anchoring site within the AB module of Kv7.2 channels
    Carolina Gomis-Perez, Alessandro Alaimo, Juncal Fernandez-Orth, Araitz Alberdi, Paloma Aivar-Mateo, Ganeko Bernardo-Seisdedos, Covadonga Malo, Pilar Areso, Antonio Felipe, Alvaro Villarroel
    Journal of Cell Science 2015 128: 3155-3163; doi: 10.1242/jcs.174128

    Summary: A new dispensable site in the Kv7.2 channel affects its regulation by CaM, such that its function can be rescued by CaM when one of the other two CaM-interaction sites is impaired.

ARTICLES OF INTEREST IN OTHER COB JOURNALS

From Development

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    Bi-directional gap junction-mediated soma-germline communication is essential for spermatogenesis
    Christopher M. Smendziuk, A. Anat Messenberg, Wayne Vogl, Guy Tanentzapf
    Journal of Cell Science 2015 128: e1.1 doi: 10.1242/jcs.178442
  • You have accessSubscription required
    Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis
    Nanbing Li-Villarreal, Meredyth M. Forbes, Andrew J. Loza, Jiakun Chen, Taylur Ma, Kathryn Helde, Cecilia B. Moens, Jimann Shin, Atsushi Sawada, Anna E. Hindes, Julien Dubrulle, Alexander F. Schier, Gregory D. Longmore, Florence L. Marlow, Lilianna Solnica-Krezel
    Journal of Cell Science 2015 128: e1.2 doi: 10.1242/jcs.178459
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  • Open Access

    SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72

    Mirjana Malnar, Boris Rogelj
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    Calcium elevations disrupt interactions between intraflagellar transport and the flagella membrane in Chlamydomonas

    Cecile Fort, Peter Collingridge, Colin Brownlee, Glen Wheeler
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    Intercellular and intracellular cilia orientation is coordinated by CELSR1 and CAMSAP3 in oviduct multiciliated cells

    Fumiko Matsukawa Usami, Masaki Arata, Dongbo Shi, Sanae Oka, Yoko Higuchi, Fadel Tissir, Masatoshi Takeichi, Toshihiko Fujimori
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    Cortical recruitment of centralspindlin and RhoA effectors during meiosis I of C. elegans primary spermatocytes

    Xiangchuan Wang, Dandan Zhang, Cunni Zheng, Shian Wu, Michael Glotzer, Yu Chung Tse
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    An endometrial organoid model of Chlamydia-epithelial and immune cell interactions

    Lee Dolat, Raphael H. Valdivia
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