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Research Article
A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1
Ilse Timmerman, Niels Heemskerk, Jeffrey Kroon, Antje Schaefer, Jos van Rijssel, Mark Hoogenboezem, Jakobus van Unen, Joachim Goedhart, Theodorus W. J. Gadella, Jr, Taofei Yin, Yi Wu, Stephan Huveneers, Jaap D. van Buul
Journal of Cell Science 2015 128: 3041-3054; doi: 10.1242/jcs.168674
Ilse Timmerman
1Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam 1066 CX, The Netherlands
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Niels Heemskerk
1Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam 1066 CX, The Netherlands
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Jeffrey Kroon
1Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam 1066 CX, The Netherlands
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Antje Schaefer
1Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam 1066 CX, The Netherlands
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Jos van Rijssel
1Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam 1066 CX, The Netherlands
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Mark Hoogenboezem
1Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam 1066 CX, The Netherlands
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Jakobus van Unen
2Swammerdam Institute for Life Sciences, Section of Molecular Cytology, van Leeuwenhoek Centre for Advanced Microscopy, University of Amsterdam, Amsterdam 1098 XH, The Netherlands
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Joachim Goedhart
2Swammerdam Institute for Life Sciences, Section of Molecular Cytology, van Leeuwenhoek Centre for Advanced Microscopy, University of Amsterdam, Amsterdam 1098 XH, The Netherlands
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Theodorus W. J. Gadella Jr
2Swammerdam Institute for Life Sciences, Section of Molecular Cytology, van Leeuwenhoek Centre for Advanced Microscopy, University of Amsterdam, Amsterdam 1098 XH, The Netherlands
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Taofei Yin
3Center for Cell Analysis and Modelling, University of Connecticut Health Center, Farmington, CT 06032, USA
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Yi Wu
3Center for Cell Analysis and Modelling, University of Connecticut Health Center, Farmington, CT 06032, USA
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Stephan Huveneers
1Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam 1066 CX, The Netherlands
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Jaap D. van Buul
1Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam 1066 CX, The Netherlands
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  • For correspondence: j.vanbuul@sanquin.nl
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Article Information

vol. 128 no. 16, 3041-3054

DOI 
https://doi.org/10.1242/jcs.168674
PubMed 
26116572

Published By 
The Company of Biologists Ltd
Print ISSN 
0021-9533
Online ISSN 
1477-9137
History 
  • Received January 20, 2015
  • Accepted June 22, 2015
  • Published online August 15, 2015.
Posted online 
June 26, 2015
Copyright & Usage 
© 2015. Published by The Company of Biologists Ltd

Article Versions

  • Previous version (June 26, 2015 - 00:33).
  • You are viewing the most recent version of this article.

Author Information

  1. Ilse Timmerman1,
  2. Niels Heemskerk1,
  3. Jeffrey Kroon1,
  4. Antje Schaefer1,
  5. Jos van Rijssel1,
  6. Mark Hoogenboezem1,
  7. Jakobus van Unen2,
  8. Joachim Goedhart2,
  9. Theodorus W. J. Gadella Jr2,
  10. Taofei Yin3,
  11. Yi Wu3,
  12. Stephan Huveneers1 and
  13. Jaap D. van Buul1,*
  1. 1Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam 1066 CX, The Netherlands
  2. 2Swammerdam Institute for Life Sciences, Section of Molecular Cytology, van Leeuwenhoek Centre for Advanced Microscopy, University of Amsterdam, Amsterdam 1098 XH, The Netherlands
  3. 3Center for Cell Analysis and Modelling, University of Connecticut Health Center, Farmington, CT 06032, USA
  1. ↵*Author for correspondence (j.vanbuul{at}sanquin.nl)
View Abstract

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Keywords

  • Trio
  • VE-cadherin
  • GEF
  • Rac1
  • Endothelium

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Research Article
A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1
Ilse Timmerman, Niels Heemskerk, Jeffrey Kroon, Antje Schaefer, Jos van Rijssel, Mark Hoogenboezem, Jakobus van Unen, Joachim Goedhart, Theodorus W. J. Gadella, Jr, Taofei Yin, Yi Wu, Stephan Huveneers, Jaap D. van Buul
Journal of Cell Science 2015 128: 3041-3054; doi: 10.1242/jcs.168674
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Research Article
A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1
Ilse Timmerman, Niels Heemskerk, Jeffrey Kroon, Antje Schaefer, Jos van Rijssel, Mark Hoogenboezem, Jakobus van Unen, Joachim Goedhart, Theodorus W. J. Gadella, Jr, Taofei Yin, Yi Wu, Stephan Huveneers, Jaap D. van Buul
Journal of Cell Science 2015 128: 3041-3054; doi: 10.1242/jcs.168674

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