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COMMENTARY
- Building an integrated model of chromosome congression
Summary: This Commentary documents recent advances concerning the two kinetochore-based force-generating mechanisms that drive mitotic chromosome congression in vertebrate cells.
RESEARCH ARTICLES
- Volume regulation and shape bifurcation in the cell nucleus
Highlighted Article: Depending on the physical environment of the cell, the nuclear volume can change dramatically. Cytoskeletal filaments and motors are involved in regulating nuclear volume.
- Binding partners of the kinase domains in Drosophila obscurin and their effect on the structure of the flight muscle
Summary: Obscurin is a titin-like protein in Drosophila muscle, which has two pseudokinase domains. These bind ligands essential for the correct assembly of the filament lattice.
- mRNA encoding Sec61β, a tail-anchored protein, is localized on the endoplasmic reticulum
Highlighted Article: The mRNA encoding certain tail-anchored proteins is directly localized to the surface of the endoplasmic reticulum, facilitating the insertion of newly synthesized proteins into the membrane.
- KCNK1 inhibits osteoclastogenesis by blocking the Ca2+ oscillation and JNK–NFATc1 signaling axis
Summary: The inwardly rectifying K+ channel KCNK1 negatively regulates osteoclast differentiation.
- A Chlamydia effector recruits CEP170 to reprogram host microtubule organization
Highlighted Article: Chlamydia trachomatis is an obligate intracellular pathogen. Here, we describe how the Chlamydia virulence protein IPAM interacts with the host protein CEP170 to reprogram host MT organization.
- Vinculin phosphorylation at residues Y100 and Y1065 is required for cellular force transmission
Summary: Src-mediated phosphorylation on Y100 and Y1065 is a prerequisite for vinculin activation, and controls cytoskeletal mechanics by regulating force transmission between the actin cytoskeleton and focal adhesion proteins.
- Induction of lateral lumens through disruption of a monoleucine-based basolateral-sorting motif in betacellulin
Highlighted Article: The EGFR ligand betacellulin contains a cytoplasmic basolateral-sorting motif. Mistrafficking of betacellulin, but not other EGFR ligands, induces EGFR-dependent lateral lumens in polarized MDCK cells.
- Endomembrane PtdIns(3,4,5)P3 activates the PI3K–Akt pathway
Summary: It had previously been understood that Akt activation occurs solely at the plasma membrane. We show that PtdIns(3,4,5)P3-dependent in situ activation of Akt can occur in subcellular compartments.
- The lysine demethylase LSD1 is required for nuclear envelope formation at the end of mitosis
Highlighted Article: Interfering with lysine demethylase LSD1 function severely affects nuclear envelope and pore complex reformation at the end of mitosis, indicating that changes on the chromatin landscape regulate these processes.
- The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration
Summary: The NMDA receptor and LRP1 function as co-receptors in Schwann cells, activating cell signaling in response to protein ligands and promoting cell survival and migration.
- Regulation of the neuronal KCNQ2 channel by Src – a dual rearrangement of the cytosolic termini underlies bidirectional regulation of gating
Summary: Src regulates the KCNQ2 channel through a dual rearrangement of cytosolic termini that underlies upregulation of single-channel gating and a reduction in the number of functional channels.
- The caspase-3–p120-RasGAP module generates a NF-κB repressor in response to cellular stress
Summary: Mild caspase activation in cells subjected to non-lethal doses of stress generates an N-terminal p120 RasGAP fragment that inhibits NF-κB activity.
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Introducing FocalPlane’s new Community Manager, Esperanza Agullo-Pascual
We are pleased to welcome Esperanza to the Journal of Cell Science team. The new Community Manager for FocalPlane, Esperanza is joining us from the Microscopy Core at Mount Sinai School of Medicine. Find out more about Esperanza in her introductory post over on FocalPlane.
New funding scheme supports sustainable events
As part of our Sustainable Conferencing Initiative, we are pleased to announce funding for organisers that seek to reduce the environmental footprint of their event. The next deadline to apply for a Scientific Meeting grant is 26 March 2021.
Read & Publish participation continues to grow
"Alongside pre-printing for early documentation of work, such mechanisms are particularly helpful for early-career researchers like me.”
Dr Chris MacDonald (University of York) shares his experience of publishing Open Access as part of our growing Read & Publish initiative. We now have over 150 institutions in 15 countries and four library consortia taking part – find out more and view our full list of participating institutions.
Cell scientist to watch: Romain Levayer
In an interview, Romain Levayer talks about starting his own lab, his love for preprints and his experience of balancing parenting with his research goals.
Live lactating mammary tissue
In a stunning video, Stewart et al. demonstrate warping of the alveolar unit due to basal cell-generated force as part of their recent work investigating roles for mechanically activated ion channels in lactation and involution.
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JCS and COVID-19
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