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December, 2015; 128 (23)

IN THIS ISSUE

  • You have accessSubscription required
    Rop regulates dendrite growth
    Journal of Cell Science 2015 128: e2301
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    NRG1–ErbB2–ErbB3 axis in human placental development
    Journal of Cell Science 2015 128: e2302
  • You have accessSubscription required
    Phosphoinositide turnover in Drosophila
    Journal of Cell Science 2015 128: e2303
  • You have accessSubscription required
    A role for Luman in osteoclast differentiation
    Journal of Cell Science 2015 128: e2304
  • You have accessSubscription required
    A Sqstm1–GFP knock-in mouse
    Journal of Cell Science 2015 128: e2305

EDITORIAL

  • You have accessSubscription required
    Plus ça change…
    Sharon A. Ahmad (Executive Editor), Michael Way (Editor-in-Chief)
    Journal of Cell Science 2015 128: 4247-4248; doi: 10.1242/jcs.182055

STICKY WICKET

  • You have accessSubscription required
    For the first time!
    Mole
    Journal of Cell Science 2015 128: 4249-4250; doi: 10.1242/jcs.179028

CELL SCIENTISTS TO WATCH

  • You have accessSubscription required
    Cell scientist to watch – Christine Mayr
    Journal of Cell Science 2015 128: 4251-4252; doi: 10.1242/jcs.181958

OBITUARY

  • You have accessSubscription required
    Professor Sir Henry Harris (1925–2014)
    Fiona M. Watt
    Journal of Cell Science 2015 128: 4253 doi: 10.1242/jcs.181859

CELL SCIENCE AT A GLANCE

  • You have accessSubscription required
    ATM and ATR signaling at a glance
    Poorwa Awasthi, Marco Foiani, Amit Kumar
    Journal of Cell Science 2015 128: 4255-4262; doi: 10.1242/jcs.169730

    Summary: Discussion of the current understanding of ATM and ATR activation, and their relevance in maintaining cell physiology and in cancer.

COMMENTARY

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    Structure and function of longin SNAREs
    Frédéric Daste, Thierry Galli, David Tareste
    Journal of Cell Science 2015 128: 4263-4272; doi: 10.1242/jcs.178574

    Summary: Longin domains play fundamental roles in intracellular trafficking by regulating the membrane localization and membrane fusion activity of SNARE proteins.

SHORT REPORT

  • You have accessSubscription required
    Ubiquitylation of CD98 limits cell proliferation and clonal expansion
    Jailal N. G. Ablack, Patrick J. Metz, John T. Chang, Joseph M. Cantor, Mark H. Ginsberg
    Journal of Cell Science 2015 128: 4273-4278; doi: 10.1242/jcs.178129

    Summary: Ubiquitylation of CD98 regulates its expression, and is a mechanism to limit the clonal expansion of T lymphocytes and potentially of other normal and transformed cells.

RESEARCH ARTICLES

  • You have accessSubscription required
    Regulation of dendrite growth and maintenance by exocytosis
    Yun Peng, Jiae Lee, Kimberly Rowland, Yuhui Wen, Hope Hua, Nicole Carlson, Shweta Lavania, Jay Z. Parrish, Michael D. Kim
    Journal of Cell Science 2015 128: 4279-4292; doi: 10.1242/jcs.174771

    Highlighted Article: This study characterizes the interaction between Drosophila Rop and the exocyst in control of dendritic morphogenesis, and demonstrates how membrane is allocated in dendrites to facilitate growth.

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    Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development
    Bertha C. Elias, Amrita Das, Diptiben V. Parekh, Glenda Mernaugh, Rebecca Adams, Zhufeng Yang, Cord Brakebusch, Ambra Pozzi, Denise K. Marciano, Thomas J. Carroll, Roy Zent
    Journal of Cell Science 2015 128: 4293-4305; doi: 10.1242/jcs.164509

    Summary: Cdc42 regulates tubulogenesis in the kidney by controlling the polarity Par complex (Par3–Par6–aPKC–Cdc42) and the cytoskeletal proteins N-Wasp and ezrin.

  • Open Access
    Neuregulin-1-mediated ErbB2–ErbB3 signalling protects human trophoblasts against apoptosis to preserve differentiation
    Valerie Fock, Kerstin Plessl, Peter Draxler, Gerlinde Regina Otti, Christian Fiala, Martin Knöfler, Jürgen Pollheimer
    Journal of Cell Science 2015 128: 4306-4316; doi: 10.1242/jcs.176933

    Highlighted Article: Decidual-stromal-cell-derived neuregulin-1 induces ErbB2–ErbB3 heterodimerization in extravillous trophoblasts and stabilizes trophoblast differentiation through suppression of apoptosis.

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    p114RhoGEF governs cell motility and lumen formation during tubulogenesis through a ROCK–myosin-II pathway
    Minji Kim, Annette M. Shewan, Andrew J. Ewald, Zena Werb, Keith E. Mostov
    Journal of Cell Science 2015 128: 4317-4327; doi: 10.1242/jcs.172361

    Summary: p114RhoGEF governs cell motility and lumen formation, suggesting that cell movement is necessary for consolidating multiple lumens into a single lumen.

  • Open Access
    In vivo tracking of phosphoinositides in Drosophila photoreceptors
    Roger C. Hardie, Che-Hsiung Liu, Alexander S. Randall, Sukanya Sengupta
    Journal of Cell Science 2015 128: 4328-4340; doi: 10.1242/jcs.180364

    Highlighted Article: A range of genetically targeted lipid probes were used to track and quantify phosphoinositide turnover in the photoreceptors of completely intact living flies, with a precision unsurpassed in other systems.

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    SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1
    Marjorie Côte, Camille Fos, Ann J. Canonigo-Balancio, Klaus Ley, Stéphane Bécart, Amnon Altman
    Journal of Cell Science 2015 128: 4341-4352; doi: 10.1242/jcs.172742

    Summary: This study reveals a new signaling pathway that mediates TCR-induced LFA-1 activation, involving SWAP-70-like adaptor of T cells (SLAT).

  • Open Access
    Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization
    Soshi Kanemoto, Yasuhiro Kobayashi, Teruhito Yamashita, Takeshi Miyamoto, Min Cui, Rie Asada, Xiang Cui, Kenta Hino, Masayuki Kaneko, Tomoko Takai, Koji Matsuhisa, Naoyuki Takahashi, Kazunori Imaizumi
    Journal of Cell Science 2015 128: 4353-4365; doi: 10.1242/jcs.176057

    Highlighted Article: Luman, an ER-resident transcription factor, regulates the multinucleation of osteoclasts by promoting cell fusion of mononuclear osteoclasts through DC-STAMP induction and transportation during osteoclastogenesis.

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    Carcinoma cells induce lumen filling and EMT in epithelial cells through soluble E-cadherin-mediated activation of EGFR
    Pratima U. Patil, Julia D'Ambrosio, Landon J. Inge, Robert W. Mason, Ayyappan K. Rajasekaran
    Journal of Cell Science 2015 128: 4366-4379; doi: 10.1242/jcs.173518

    Summary: A 3D co-culture system comprising non-transformed epithelial cells and transformed carcinoma cells demonstrates that carcinoma cells sequentially induce sE-cad-dependent lumen filling and EMT.

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    Dynamics of chromatin accessibility and epigenetic state in response to UV damage
    Sandra Schick, David Fournier, Sudhir Thakurela, Sanjeeb Kumar Sahu, Angela Garding, Vijay K. Tiwari
    Journal of Cell Science 2015 128: 4380-4394; doi: 10.1242/jcs.173633

    Summary: Exposure to UV irradiation causes genome-wide changes in chromatin accessibility and epigenetic state.

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    Drosophila Lipin interacts with insulin and TOR signaling pathways in the control of growth and lipid metabolism
    Sandra Schmitt, Rupali Ugrankar, Stephanie E. Greene, Meenakshi Prajapati, Michael Lehmann
    Journal of Cell Science 2015 128: 4395-4406; doi: 10.1242/jcs.173740

    Summary: The insulin receptor and TORC1 pathways independently control cytoplasmic and nuclear functions of Drosophila Lipin, and Lipin, in turn, modulates cellular responses to growth factor signaling.

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    Sorting nexin 5 selectively regulates dorsal-ruffle-mediated macropinocytosis in primary macrophages
    Jet Phey Lim, Prajakta Gosavi, Justine D. Mintern, Ellen M. Ross, Paul A. Gleeson
    Journal of Cell Science 2015 128: 4407-4419; doi: 10.1242/jcs.174359

    Summary: An analysis of SNX5-knockout mice shows that SNX5 is essential for the biogenesis of macropinosomes from dorsal ruffles and that dorsal ruffles provide a major contribution to macropinocytosis in activated macrophages.

  • Open Access
    Stress-induced inhibition of translation independently of eIF2α phosphorylation
    Jon Halvor Jonsrud Knutsen, Gro Elise Rødland, Cathrine Arnason Bøe, Tine Weise Håland, Per Sunnerhagen, Beáta Grallert, Erik Boye
    Journal of Cell Science 2015 128: 4420-4427; doi: 10.1242/jcs.176545

    Summary: In contrast to textbook knowledge, the phosphorylation of translation initiation factor eIF2α is not required for UV-induced inhibition of protein synthesis, which we show in three different cell types.

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    Spatial control of Shoc2-scaffold-mediated ERK1/2 signaling requires remodeling activity of the ATPase PSMC5
    Eun Ryoung Jang, HyeIn Jang, Ping Shi, Gabriel Popa, Myoungkun Jeoung, Emilia Galperin
    Journal of Cell Science 2015 128: 4428-4441; doi: 10.1242/jcs.177543

    Summary: Our studies describe a new, multi-level paradigm in which allosteric modifications alter the ability of the scaffold protein Shoc2 to actively accelerate transmission of ERK1/2 signals.

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    CaV3.2 T-type channels mediate Ca2+ entry during oocyte maturation and following fertilization
    Miranda L. Bernhardt, Yingpei Zhang, Christian F. Erxleben, Elizabeth Padilla-Banks, Caitlin E. McDonough, Yi-Liang Miao, David L. Armstrong, Carmen J. Williams
    Journal of Cell Science 2015 128: 4442-4452; doi: 10.1242/jcs.180026

    Summary: In mouse oocytes, CaV3.2 T-type channels have previously unrecognized roles in supporting accrual of Ca2+ stores during oocyte maturation and in mediating Ca2+ influx following fertilization.

TOOLS AND TECHNIQUES

  • Open Access
    Sqstm1–GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells
    Atsushi Eino, Shun Kageyama, Takefumi Uemura, Hiromichi Annoh, Tetsuya Saito, Ichiei Narita, Satoshi Waguri, Masaaki Komatsu
    Journal of Cell Science 2015 128: 4453-4461; doi: 10.1242/jcs.180174

    Highlighted Article: We have developed Sqstm1-GFP knock-in mice, which are useful for elucidating the molecular mechanisms of cellular events, including autophagy, and various diseases in which Sqstm1 plays a role.

CORRECTION

  • You have accessSubscription required
    Sonic hedgehog processing and release are regulated by glypican heparan sulfate proteoglycans
    Corinna Ortmann, Ute Pickhinke, Sebastian Exner, Stefanie Ohlig, Roger Lawrence, Hamodah Jboor, Rita Dreier, Kay Grobe
    Journal of Cell Science 2015 128: 4462 doi: 10.1242/jcs.182360

ARTICLES OF INTEREST IN OTHER COB JOURNALS

  • From Development

    • You have accessSubscription required
      The Atg1-Tor pathway regulates yolk catabolism in Drosophila embryos
      Hallie Kuhn, Richelle Sopko, Margaret Coughlin, Norbert Perrimon, Tim Mitchison
      Journal of Cell Science 2015 128: e1.1 doi: 10.1242/jcs.183491
    • You have accessSubscription required
      Mechano-logical model of C. elegans germ line suggests feedback on the cell cycle
      Kathryn Atwell, Zhao Qin, David Gavaghan, Hillel Kugler, E. Jane Albert Hubbard, James M. Osborne
      Journal of Cell Science 2015 128: e1.2 doi: 10.1242/jcs.183509
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    Importin-9 regulates chromosome segregation and packaging in Drosophila germ cells

    Victor Palacios, Garrett C. Kimble, Tina L. Tootle, Michael Buszczak
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    The voltage-gated sodium channel β2 subunit associates with lipid rafts by S-palmitoylation

    Eric Cortada, Robert Serradesanferm, Ramon Brugada, Marcel Verges
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    Microtubule-independent movement of the fission yeast nucleus

    Sanju Ashraf, Ye Dee Tay, David A. Kelly, Kenneth E. Sawin
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    The lysosomotrope, GPN, mobilises Ca2+ from acidic organelles

    Yu Yuan, Bethan S. Kilpatrick, Susanne Gerndt, Franz Bracher, Christian Grimm, Anthony H. Schapira, Sandip Patel
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  • Open Access

    The Formin Inhibitor, SMIFH2, Inhibits Members of the Myosin Superfamily

    Yukako Nishimura, Shidong Shi, Fang Zhang, Rong Liu, Yasuharu Takagi, Alexander D. Bershadsky, Virgile Viasnoff, James R. Sellers
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