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May, 2016; 129 (10)

IN THIS ISSUE

  • You have accessSubscription required
    Prelamin A mutation that causes progeroid disorder
    Journal of Cell Science 2016 129: e1001
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    SNAIL1: a mechanoresponsive transcriptional regulator of CAFs
    Journal of Cell Science 2016 129: e1002
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    Interplay between Ca2+ and Zn2+ in cell migration
    Journal of Cell Science 2016 129: e1003
  • You have accessSubscription required
    How ethylene reorientates cortical microtubules in seedlings
    Journal of Cell Science 2016 129: e1004
  • You have accessSubscription required
    3D models of short IFT trains in Chlamydomonas flagella
    Journal of Cell Science 2016 129: e1005

COMMENTARIES

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    Nuclear migration events throughout development
    Courtney R. Bone, Daniel A. Starr
    Journal of Cell Science 2016 129: 1951-1961; doi: 10.1242/jcs.179788

    Summary: Nuclear migration is a central part of many cell and developmental processes. A surprisingly large number of different molecular mechanisms exist to move nuclei to specific, intracellular locations.

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    Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT–PIX complexes
    Wu Zhou, Xiaobo Li, Richard T. Premont
    Journal of Cell Science 2016 129: 1963-1974; doi: 10.1242/jcs.179465

    Summary: In this Commentary, we discuss recent findings in key physiological systems that exemplify the current understanding of the functions of GIT, PIX and the GIT–PIX complex.

SHORT REPORTS

  • You have accessSubscription required
    A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder
    Yuexia Wang, Uta Lichter-Konecki, Kwame Anyane-Yeboa, Jessica E. Shaw, Jonathan T. Lu, Cecilia Östlund, Ji-Yeon Shin, Lorraine N. Clark, Gregg G. Gundersen, Peter L. Nagy, Howard J. Worman
    Journal of Cell Science 2016 129: 1975-1980; doi: 10.1242/jcs.187302

    Highlighted article: We describe a mutation in the human lamin A/C gene that destroys the ZMPSTE24 cleavage site and causes a progeroid disorder.

  • Open Access
    Nuclear transport of paxillin depends on focal adhesion dynamics and FAT domains
    Aneesh R. Sathe, G. V. Shivashankar, Michael P. Sheetz
    Journal of Cell Science 2016 129: 1981-1988; doi: 10.1242/jcs.172643

    Summary: We find that nuclear translocation of paxillin is tuned by focal adhesion maturation. This could provide a method for mechanosensing signals to be used by cells to control transcription.

RESEARCH ARTICLES

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    Mechanical signals regulate and activate SNAIL1 protein to control the fibrogenic response of cancer-associated fibroblasts
    Kun Zhang, Whitney R. Grither, Samantha Van Hove, Hirak Biswas, Suzanne M. Ponik, Kevin W. Eliceiri, Patricia J. Keely, Gregory D. Longmore
    Journal of Cell Science 2016 129: 1989-2002; doi: 10.1242/jcs.180539

    Highlighted article: SNAIL1 is a mechanoresponsive regulator of the fibrogenic response of tumors. The work provides insight into the transcriptional response of tumors to their microenvironment and CAF activation to sustain tumor fibrogenesis.

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    FRMD4A–cytohesin signaling modulates the cellular release of tau
    Xu Yan, Niko-Petteri Nykänen, Cecilia A. Brunello, Annakaisa Haapasalo, Mikko Hiltunen, Riikka-Liisa Uronen, Henri J. Huttunen
    Journal of Cell Science 2016 129: 2003-2015; doi: 10.1242/jcs.180745

    Summary: Cell-to-cell transmission of pathological proteins in neurodegenerative diseases is not well understood. We describe a new mechanism whereby FRMD4A, a late-onset Alzheimer's disease risk gene, regulates secretion of tau.

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    Reciprocal regulation of actin cytoskeleton remodelling and cell migration by Ca2+ and Zn2+: role of TRPM2 channels
    Fangfang Li, Nada Abuarab, Asipu Sivaprasadarao
    Journal of Cell Science 2016 129: 2016-2029; doi: 10.1242/jcs.179796

    Highlighted article: Migration of some cancer cell lines is regulated by TRPM2 channels, which modulate the levels of Zn2+ and Ca2+ ions. In turn, these two ions regulate actin cytoskeleton dynamics in a reciprocal fashion.

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    Vimentin filaments regulate integrin–ligand interactions by binding to the cytoplasmic tail of integrin β3
    Jiyoon Kim, Chansik Yang, Eun Jin Kim, Jungim Jang, Se-Jong Kim, So Min Kang, Moon Gyo Kim, Hosung Jung, Dongeun Park, Chungho Kim
    Journal of Cell Science 2016 129: 2030-2042; doi: 10.1242/jcs.180315

    Summary: Vimentin filaments underneath the plasma membrane might provide integrin-binding sites to mediate integrin clustering, which in turn can enhance integrin–ligand interaction.

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    Microtubule bundling plays a role in ethylene-mediated cortical microtubule reorientation in etiolated Arabidopsis hypocotyls
    Qianqian Ma, Jingbo Sun, Tonglin Mao
    Journal of Cell Science 2016 129: 2043-2051; doi: 10.1242/jcs.184408

    Highlighted article: Microtubule arrays are reoriented in response to ethylene-mediated etiolated hypocotyl cell elongation by regulation of microtubule bundles in certain orientations within Arabidopsis.

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    Mapping growth-factor-modulated Akt signaling dynamics
    Sean M. Gross, Peter Rotwein
    Journal of Cell Science 2016 129: 2052-2063; doi: 10.1242/jcs.183764

    Summary: Using real-time tracking of a fluorescent sensor molecule, these studies address signaling specificity by determining how actions of different growth factors are encoded into distinct Akt signaling dynamics.

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    Two classes of short intraflagellar transport train with different 3D structures are present in Chlamydomonas flagella
    Elisa Vannuccini, Eugenio Paccagnini, Francesca Cantele, Mariangela Gentile, Daniele Dini, Federica Fino, Dennis Diener, Caterina Mencarelli, Pietro Lupetti
    Journal of Cell Science 2016 129: 2064-2074; doi: 10.1242/jcs.183244

    Highlighted article: In-depth analyses of IFT train ultrastructure in regenerating Chlamydomonas flagella shows the occurrence of three train types with different 3D structure, implicating differences in function.

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    ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling
    Zhentao Sheng, Lijia Yu, Tianyi Zhang, Xun Pei, Xuan Li, Zhihua Zhang, Wei Du
    Journal of Cell Science 2016 129: 2075-2084; doi: 10.1242/jcs.182261

    Summary: Inactivation of ESCRT-0 complex promotes Rb-mutant cell death by disrupting Rhomboid endosomal trafficking and inhibiting EGFR signaling.

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    Optogenetic activation reveals distinct roles of PIP3 and Akt in adipocyte insulin action
    Yingke Xu, Di Nan, Jiannan Fan, Jonathan S. Bogan, Derek Toomre
    Journal of Cell Science 2016 129: 2085-2095; doi: 10.1242/jcs.174805

    Summary: Optogenetic activation with new PI3K and Akt probes support that both Akt-dependent and Akt-independent pathways are necessary for consistent GLUT4 translocation.

  • Open Access
    Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells
    Mafalda Lopes da Silva, Marie N. O'Connor, Janos Kriston-Vizi, Ian J. White, Raya Al-Shawi, J. Paul Simons, Julia Mössinger, Volker Haucke, Daniel F. Cutler
    Journal of Cell Science 2016 129: 2096-2105; doi: 10.1242/jcs.187864

    Summary: Phosphatidylinositol 4 kinases regulate the formation and function of an endothelial secretory organelle that is crucial for haemostasis in mammals.

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    Together, the IFT81 and IFT74 N-termini form the main module for intraflagellar transport of tubulin
    Tomohiro Kubo, Jason M. Brown, Karl Bellve, Branch Craige, Julie M. Craft, Kevin Fogarty, Karl F. Lechtreck, George B. Witman
    Journal of Cell Science 2016 129: 2106-2119; doi: 10.1242/jcs.187120

    Summary: Tubulin transport is specifically impaired by mutations to the proposed tubulin-binding domains of the intraflagellar transport proteins IFT81 and IFT74.

CORRECTION

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    Upon Wnt stimulation, Rac1 activation requires Rac1 and Vav2 binding to p120-catenin
    Gabriela Valls, Montserrat Codina, Rachel K. Miller, Beatriz Del Valle-Pérez, Meritxell Vinyoles, Carme Caelles, Pierre D. McCrea, Antonio García de Herreros, Mireia Duñach
    Journal of Cell Science 2016 129: 2120-2123; doi: 10.1242/jcs.190470

ARTICLES OF INTEREST IN OUR OTHER JOURNALS

  • From Development

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      Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis
      Sharda Prasad Yadav, Neel Kamal Sharma, Chunqiao Liu, Lijin Dong, Tiansen Li, Anand Swaroop
      Journal of Cell Science 2016 129: e1.1 doi: 10.1242/jcs.191601
    • You have accessSubscription required
      Semaphorin 3A is a retrograde cell death signal in developing sympathetic neurons
      Amanda B. Wehner, Houari Abdesselem, Travis L. Dickendesher, Fumiyasu Imai, Yutaka Yoshida, Roman J. Giger, Brian A. Pierchala
      Journal of Cell Science 2016 129: e1.2 doi: 10.1242/jcs.191593
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    PDZD8 mediated lipid transfer at ER-LE/lys contacts is required for LE/lys positioning and neurite outgrowth

    Yuan Gao, Juan Xiong, Qing-Zhu Chu, Wei-Ke Ji
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    Acidic microenvironment modulates ROR1 to promote epithelial-mesenchymal transition and hepatocarcinoma metastasis

    Xia Meng, Yurui Xu, Xinghai Ning
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    Importin-9 regulates chromosome segregation and packaging in Drosophila germ cells

    Victor Palacios, Garrett C. Kimble, Tina L. Tootle, Michael Buszczak
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    The voltage-gated sodium channel β2 subunit associates with lipid rafts by S-palmitoylation

    Eric Cortada, Robert Serradesanferm, Ramon Brugada, Marcel Verges
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    Microtubule-independent movement of the fission yeast nucleus

    Sanju Ashraf, Ye Dee Tay, David A. Kelly, Kenneth E. Sawin
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