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CELL SCIENCE AT A GLANCE
TFEB at a glance
Gennaro Napolitano, Andrea Ballabio
Journal of Cell Science 2016 129: 2475-2481; doi: 10.1242/jcs.146365
Gennaro Napolitano
1Telethon Institute of Genetics and Medicine (TIGEM), 80131 Naples, Italy
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Andrea Ballabio
1Telethon Institute of Genetics and Medicine (TIGEM), 80131 Naples, Italy
2Medical Genetics, Department of Translational Medicine, Federico II University, 80131 Naples, Italy
3Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
4Jan and Dan Duncan Neurological Research Institute, Texas Children Hospital, Houston, TX 77030, USA
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Article Information

vol. 129 no. 13, 2475-2481

DOI 
https://doi.org/10.1242/jcs.146365
PubMed 
27252382

Published By 
The Company of Biologists Ltd
Print ISSN 
0021-9533
Online ISSN 
1477-9137
History 
  • Published online July 1, 2016.
Posted online 
June 01, 2016
Copyright & Usage 
© 2016. Published by The Company of Biologists Ltd

Article Versions

  • Previous version (June 1, 2016 - 08:18).
  • You are viewing the most recent version of this article.

Author Information

  1. Gennaro Napolitano1 and
  2. Andrea Ballabio1,2,3,4,*
  1. 1Telethon Institute of Genetics and Medicine (TIGEM), 80131 Naples, Italy
  2. 2Medical Genetics, Department of Translational Medicine, Federico II University, 80131 Naples, Italy
  3. 3Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
  4. 4Jan and Dan Duncan Neurological Research Institute, Texas Children Hospital, Houston, TX 77030, USA
  1. ↵*Author for correspondence (ballabio{at}tigem.it)
View Abstract

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Keywords

  • TFEB
  • TFE3
  • MiT family
  • mTOR
  • Lysosomes
  • Autophagy
  • Lysosomal storage disorders

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CELL SCIENCE AT A GLANCE
TFEB at a glance
Gennaro Napolitano, Andrea Ballabio
Journal of Cell Science 2016 129: 2475-2481; doi: 10.1242/jcs.146365
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CELL SCIENCE AT A GLANCE
TFEB at a glance
Gennaro Napolitano, Andrea Ballabio
Journal of Cell Science 2016 129: 2475-2481; doi: 10.1242/jcs.146365

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Article navigation

  • Top
  • Article
    • ABSTRACT
    • Introduction
    • MiT family of transcription factors
    • TFEB as a master regulator of lysosomal function and autophagy
    • Regulation of TFEB activity
    • Functional in vivo studies of TFEB
    • TFEB and the MiT family in tumorigenesis
    • TFEB as a therapeutic target for diseases
    • Concluding remarks
    • Acknowledgements
    • Footnotes
    • References
  • Figures & tables
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