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August, 2016; 129 (15)

IN THIS ISSUE

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    dSTORM map of the desmosome
    Journal of Cell Science 2016 129: e1501
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    Integrin activation controls turnover
    Journal of Cell Science 2016 129: e1502
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    Cdc42GAP regulates cup closure
    Journal of Cell Science 2016 129: e1503
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    LAR phosphatase regulates cell adhesion through CDK1
    Journal of Cell Science 2016 129: e1504

CELL SCIENTISTS TO WATCH

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    Cell scientist to watch – Meritxell Huch
    Journal of Cell Science 2016 129: 2877-2879; doi: 10.1242/jcs.193797

CELL SCIENCE AT A GLANCE

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    The cytotoxic T lymphocyte immune synapse at a glance
    Nele M. G. Dieckmann, Gordon L. Frazer, Yukako Asano, Jane C. Stinchcombe, Gillian M. Griffiths
    Journal of Cell Science 2016 129: 2881-2886; doi: 10.1242/jcs.186205

    Summary: This brief review and the poster illustrate the different steps and specialised mechanisms used to focus secretion at the CTL immune synapse that allow CTLs to be such efficient and precise serial killers.

COMMENTARY

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    Regulation of myogenesis by environmental hypoxia
    Michèle Beaudry, Magdalena Hidalgo, Thierry Launay, Valérie Bello, Thierry Darribère
    Journal of Cell Science 2016 129: 2887-2896; doi: 10.1242/jcs.188904

    Summary: This Commentary presents the effects of hypoxia during embryonic development of somites, and myoblast and satellite cell proliferation and differentiation in vertebrates.

SHORT REPORTS

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    Molecular organization of the desmosome as revealed by direct stochastic optical reconstruction microscopy
    Sara N. Stahley, Emily I. Bartle, Claire E. Atkinson, Andrew P. Kowalczyk, Alexa L. Mattheyses
    Journal of Cell Science 2016 129: 2897-2904; doi: 10.1242/jcs.185785

    Highlighted Article: The nanoscale organization of proteins in the desmosome, a structure mediating strong cell–cell adhesion, is elucidated by dSTORM super-resolution fluorescence microscopy.

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    A new mechanism for nuclear import by actin-based propulsion used by a baculovirus nucleocapsid
    Shelly Au, Wei Wu, Lixin Zhou, David A. Theilmann, Nelly Panté
    Journal of Cell Science 2016 129: 2905-2911; doi: 10.1242/jcs.191668

    Summary: The baculovirus AcMNPV nucleocapsid contains a WASP-like protein that induces actin polymerization. This baculovirus-induced actin polymerization is involved in the nuclear import of the nucleocapsid.

RESEARCH ARTICLES

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    In vivo regulation of integrin turnover by outside-in activation
    Pablo López-Ceballos, Alejandra Donají Herrera-Reyes, Daniel Coombs, Guy Tanentzapf
    Journal of Cell Science 2016 129: 2912-2924; doi: 10.1242/jcs.190256

    Highlighted Article: Outside-in integrin activation regulates integrin turnover. Furthermore, integrin activation drives the developmental stabilization of cell–ECM adhesion by decreasing integrin turnover during embryogenesis.

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    Arg tyrosine kinase modulates TGF-β1 production in human renal tubular cells under high-glucose conditions
    Barbara Torsello, Cristina Bianchi, Chiara Meregalli, Vitalba Di Stefano, Lara Invernizzi, Sofia De Marco, Giorgio Bovo, Rinaldo Brivio, Guido Strada, Silvia Bombelli, Roberto A. Perego
    Journal of Cell Science 2016 129: 2925-2936; doi: 10.1242/jcs.183640

    Summary: The downregulation of Arg kinase, induced in human primary tubular cell cultures by incubation in a high glucose concentration, is specifically involved in TGF-β1 overproduction that activates fibroblasts.

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    Staphylococcus aureus recruits Cdc42GAP through recycling endosomes and the exocyst to invade human endothelial cells
    Liane Rauch, Kirsten Hennings, Claudia Trasak, Anja Röder, Barbara Schröder, Friedrich Koch-Nolte, Felix Rivera-Molina, Derek Toomre, Martin Aepfelbacher
    Journal of Cell Science 2016 129: 2937-2949; doi: 10.1242/jcs.186213

    Highlighted Article: S. aureus invasion of endothelial cells, which underlies S. aureus sepsis and endocarditis, depends on recycling-endosome-mediated recruitment of Cdc42GAP, a negative regulator of the Rho GTP-binding protein Cdc42.

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    Cadherin-11 is a novel regulator of extracellular matrix synthesis and tissue mechanics
    Sindhu Row, Yayu Liu, Stella Alimperti, Sandeep K. Agarwal, Stelios T. Andreadis
    Journal of Cell Science 2016 129: 2950-2961; doi: 10.1242/jcs.183772

    Summary: CDH11 regulates collagen and elastin synthesis by both affecting the mechanical properties and contractile function of animal tissues through TGF-β and ROCK pathways.

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    LAR protein tyrosine phosphatase regulates focal adhesions through CDK1
    Adil R. Sarhan, Trushar R. Patel, Alana R. Cowell, Michael G. Tomlinson, Carina Hellberg, John K. Heath, Debbie L. Cunningham, Neil A. Hotchin
    Journal of Cell Science 2016 129: 2962-2971; doi: 10.1242/jcs.191379

    Highlighted Article: We demonstrate that LAR, a receptor tyrosine phosphatase, signals through CDK1 to promote adhesion complex formation and adhesion to the extracellular matrix.

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    SIRT2 inactivation reveals a subset of hyperacetylated perinuclear microtubules inaccessible to HDAC6
    Renate Hvidsten Skoge, Mathias Ziegler
    Journal of Cell Science 2016 129: 2972-2982; doi: 10.1242/jcs.187518

    Summary: Analysis of hyperacetylated microtubule structures revealed overlapping and distinct functions of HDAC6 and SIRT2. Specifically, only SIRT2 acts to deacetylate hyperacetylated perinuclear microtubules.

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    Dephosphorylation of MAP2D enhances its binding to vimentin in preovulatory ovarian granulosa cells
    Maxfield P. Flynn, Sarah E. Fiedler, Amelia B. Karlsson, Daniel W. Carr, Evelyn T. Maizels, Mary Hunzicker-Dunn
    Journal of Cell Science 2016 129: 2983-2996; doi: 10.1242/jcs.190397

    Summary: The progesterone synthetic response of preovulatory granulosa cells might be facilitated by dephosphorylation of MAP2D and phosphorylation of vimentin, resulting in reorganization of vimentin filaments.

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    Retinoic-acid-mediated HRas stabilization induces neuronal differentiation of neural stem cells during brain development
    Jong-Chan Park, Woo-Jeong Jeong, Mi-Yeon Kim, DoSik Min, Kang-Yell Choi
    Journal of Cell Science 2016 129: 2997-3007; doi: 10.1242/jcs.184366

    Summary: Retinoic acid stabilizes HRas protein during neurogenesis, and this is required for the neural stem cell differentiation into neurons and murine brain development.

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    An organelle K+ channel is required for osmoregulation in Chlamydomonas reinhardtii
    Feifei Xu, Xiaoan Wu, Lin-Hua Jiang, Hucheng Zhao, Junmin Pan
    Journal of Cell Science 2016 129: 3008-3014; doi: 10.1242/jcs.188441

    Summary: We identify a new K+ channel, denoted KCN11, that is localized to the contractile vacuole, and functions in contractile vacuole contraction and osmoregulation in Chlamydomonas reinhardtii.

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    Aurora A kinase regulates proper spindle positioning in C. elegans and in human cells
    Sachin Kotak, Katayon Afshar, Coralie Busso, Pierre Gönczy
    Journal of Cell Science 2016 129: 3015-3025; doi: 10.1242/jcs.184416

    Summary: Aurora A kinase and PP6 phosphatase are required for spindle positioning in C. elegans embryos and human cells by modulating the localization of cortical force generators.

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    Intraflagellar transport is required for the maintenance of the trypanosome flagellum composition but not its length
    Cécile Fort, Serge Bonnefoy, Linda Kohl, Philippe Bastin
    Journal of Cell Science 2016 129: 3026-3041; doi: 10.1242/jcs.188227

    Summary: Intraflagellar transport machinery is responsible for the construction of cilia and flagella. We show that in trypanosomes it is required for the maintenance of flagellum integrity but not of organelle length.

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    ‘Rod and ring’ formation from IMP dehydrogenase is regulated through the one-carbon metabolic pathway
    S. John Calise, Daniel L. Purich, Thuy Nguyen, Dania A. Saleem, Claire Krueger, Joyce D. Yin, Edward K. L. Chan
    Journal of Cell Science 2016 129: 3042-3052; doi: 10.1242/jcs.183400

    Summary: Two enzymes in one-carbon metabolism play a pivotal role in controlling assembly and disassembly of a filamentous structure of IMPDH that might act as an adaptive mechanism in nucleotide homeostasis.

CORRECTIONS

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    The role of palmitoylation and transmembrane domain in sorting of transmembrane adaptor proteins
    Tomáš Chum, Daniela Glatzová, Zuzana Kvíčalová, Jan Malínský, Tomáš Brdička, Marek Cebecauer
    Journal of Cell Science 2016 129: 3053 doi: 10.1242/jcs.194209
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    Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak
    Stephanie Einsele-Scholz, Silke Malmsheimer, Katrin Bertram, Daniel Stehle, Janina Johänning, Marianne Manz, Peter T. Daniel, Bernhard F. Gillissen, Klaus Schulze-Osthoff, Frank Essmann
    Journal of Cell Science 2016 129: 3054 doi: 10.1242/jcs.193946

ARTICLES OF INTEREST IN OUR OTHER JOURNALS

  • From Development

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      Alk1 controls arterial endothelial cell migration in lumenized vessels
      Elizabeth R. Rochon, Prahlad G. Menon, Beth L. Roman
      Journal of Cell Science 2016 129: e1.1 doi: 10.1242/jcs.195545
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      Cell adhesion in plants is under the control of putative O-fucosyltransferases
      Stéphane Verger, Salem Chabout, Emilie Gineau, Grégory Mouille
      Journal of Cell Science 2016 129: e1.2 doi: 10.1242/jcs.195537
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    An SNX10-dependent mechanism down-regulates fusion between mature osteoclasts

    Maayan Barnea Zohar, Sabina E. Winograd-Katz, Moran Shalev, Esther Arman, Nina Reuven, Lee Roth, Ofra Golani, Merle Stein, Fadi Thalji, Moien Kanaan, Jan Tuckermann, Benjamin Geiger, Ari Elson
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    Non-canonical ago loading of EV-derived exogenous single stranded miRNA in recipient cells

    Bartika Ghoshal, Edouard Bertrand, Suvendra N. Bhattacharyya
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    INPP5E controls ciliary localization of phospholipids and odor response in olfactory sensory neurons

    Kirill Ukhanov, Cedric Uytingco, Warren Green, Lian Zhang, Stephane Schurmans, Jeffrey R. Martens
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    Methanol sensor Wsc1 and MAP kinase suppress degradation of methanol-induced peroxisomes in methylotrophic yeast

    Shin Ohsawa, Koichi Inoue, Takahiro Isoda, Masahide Oku, Hiroya Yurimoto, Yasuyoshi Sakai
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    WNT responsive SUMOylation of ZIC5 promotes murine neural crest cell development via multiple effects on transcription

    Radiya G. Ali, Helen M. Bellchambers, Nicholas Warr, Jehangir N. Ahmed, Kristen S. Barratt, Kieran Neill, Koula E. M. Diamand, Ruth M. Arkell
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