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January, 2016; 129 (2)

IN THIS ISSUE

  • You have accessSubscription required
    Formins help podosomes form
    Journal of Cell Science 2016 129: e0201
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    The power of intravital correlative imaging
    Journal of Cell Science 2016 129: e0202
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    PTP-PEST in Eph signalling
    Journal of Cell Science 2016 129: e0203
  • You have accessSubscription required
    Mon1–Ccz1 and Rab7: location, location, location
    Journal of Cell Science 2016 129: e0204

CELL SCIENTISTS TO WATCH

  • You have accessSubscription required
    Cell scientist to watch – Lei Stanley Qi
    Journal of Cell Science 2016 129: 243-244; doi: 10.1242/jcs.182196

COMMENTARIES

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    Third harmonic generation microscopy of cells and tissue organization
    Bettina Weigelin, Gert-Jan Bakker, Peter Friedl
    Journal of Cell Science 2016 129: 245-255; doi: 10.1242/jcs.152272

    Summary: The basis of third harmonic generation microscopy and its versatile applications in cell and tissue research are reviewed, as well as its emerging applicability in clinical practice.

  • You have accessSubscription required
    Computational ‘microscopy’ of cellular membranes
    Helgi I. Ingólfsson, Clément Arnarez, Xavier Periole, Siewert J. Marrink
    Journal of Cell Science 2016 129: 257-268; doi: 10.1242/jcs.176040

    Summary: Computational modelling, or ‘microscopy’, has emerged as a powerful tool to study cell membranes across a broad range of resolutions, complementing experimental microscopy methods.

SHORT REPORT

  • Open Access
    Wnt/β-catenin and LIF–Stat3 signaling pathways converge on Sp5 to promote mouse embryonic stem cell self-renewal
    Shoudong Ye, Dongming Zhang, Fei Cheng, Daniel Wilson, Jeffrey Mackay, Kan He, Qian Ban, Feng Lv, Saifei Huang, Dahai Liu, Qi-Long Ying
    Journal of Cell Science 2016 129: 269-276; doi: 10.1242/jcs.177675

    Summary: This study reveals a new function of Sp5 in mouse embryonic stem cell (ESC) self-renewal mediated by CHIR99021 and LIF, and reprogramming of EpiSCs into naїve ESCs.

RESEARCH ARTICLES

  • You have accessSubscription required
    PTP-PEST controls EphA3 activation and ephrin-induced cytoskeletal remodelling
    Mariam Mansour, Eva Nievergall, Kristina Gegenbauer, Carmen Llerena, Lakmali Atapattu, Maxime Hallé, Michel L. Tremblay, Peter W. Janes, Martin Lackmann
    Journal of Cell Science 2016 129: 277-289; doi: 10.1242/jcs.174490

    Highlighted Article: This study shows new roles for the protein tyrosine phosphatase PTP-PEST in controlling EphA3 receptor tyrosine kinase activity, trafficking and Eph-induced cell retraction.

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    Role of epithelial Na+ channels in endothelial function
    Dongqing Guo, Shenghui Liang, Su Wang, Chengchun Tang, Bin Yao, Wenhui Wan, Hailing Zhang, Hui Jiang, Asif Ahmed, Zhiren Zhang, Yuchun Gu
    Journal of Cell Science 2016 129: 290-297; doi: 10.1242/jcs.168831

    Summary: ENaCs endogenous to human endothelial cells are mechano-sensitive. Persistent activation of ENaCs will inevitably lead to endothelium dysfunction and even vascular diseases.

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    The formins FHOD1 and INF2 regulate inter- and intra-structural contractility of podosomes
    Linda Panzer, Leona Trübe, Matthias Klose, Ben Joosten, Johan Slotman, Alessandra Cambi, Stefan Linder
    Journal of Cell Science 2016 129: 298-313; doi: 10.1242/jcs.177691

    Highlighted Article: This study identifies the formins FHOD1 and INF2 as new components of podosomes in primary human macrophages, which regulate inter- and intra-structural contractility at discrete podosome substructures.

  • Open Access
    Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of annexin A2
    Ann Kari Grindheim, Hanne Hollås, Aase M. Raddum, Jaakko Saraste, Anni Vedeler
    Journal of Cell Science 2016 129: 314-328; doi: 10.1242/jcs.173195

    Summary: Reactive oxygen species cause two opposite and transient Tyr23-based modifications of annexin A2; its dephosphorylation in the nucleus and phosphorylation at the cell cortex, resulting in release of the protein in exosomes.

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    Mon1–Ccz1 activates Rab7 only on late endosomes and dissociates from the lysosome in mammalian cells
    Sayaka Yasuda, So Morishita, Akane Fujita, Tomohisa Nanao, Naoyuki Wada, Satoshi Waguri, Giampietro Schiavo, Mitsunori Fukuda, Takeshi Nakamura
    Journal of Cell Science 2016 129: 329-340; doi: 10.1242/jcs.178095

    Highlighted Article: A combination of a Rab7 sensor and confocal FRET imaging techniques revealed that the Mon1–Ccz1 complex activates Rab7 only on late endosome and dissociates from lysosome in mammalian cells.

  • You have accessSubscription required
    Loss of PGL-1 and PGL-3, members of a family of constitutive germ-granule components, promotes germline apoptosis in C. elegans
    Hyemin Min, Yhong-Hee Shim, Ichiro Kawasaki
    Journal of Cell Science 2016 129: 341-353; doi: 10.1242/jcs.174201

    Summary: PGL-1 and PGL-3, members of a family of constitutive germ-granule components, suppress excessive germline apoptosis by repressing both the protein levels of CED-4 and the cytoplasmic translocation of SIR-2.1 in C. elegans.

  • You have accessSubscription required
    FGF control of E-cadherin targeting in the Drosophila midgut impacts on primordial germ cell motility
    Guillem Parés, Sara Ricardo
    Journal of Cell Science 2016 129: 354-366; doi: 10.1242/jcs.174284

    Summary: FGF signaling modulates zygotic E-cadherin distribution to maintain posterior midgut epithelial 3D architecture, impacting on primordial germ cell motility during Drosophila early embryonic development.

  • You have accessSubscription required
    Srv2/CAP is required for polarized actin cable assembly and patch internalization during clathrin-mediated endocytosis
    Junko Y. Toshima, Chika Horikomi, Asuka Okada, Makiko N. Hatori, Makoto Nagano, Atsushi Masuda, Wataru Yamamoto, Daria Elisabeth Siekhaus, Jiro Toshima
    Journal of Cell Science 2016 129: 367-379; doi: 10.1242/jcs.176651

    Summary: Srv2/CAP is required for efficient endocytosis owing to its role in the formation of the actin patches that aid in vesicle invagination and in the formation of the actin cables that these move along.

  • You have accessSubscription required
    PAK6 targets to cell–cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape
    Elizabeth M. Morse, Xiaowen Sun, Jordan R. Olberding, Byung Hak Ha, Titus J. Boggon, David A. Calderwood
    Journal of Cell Science 2016 129: 380-393; doi: 10.1242/jcs.177493

    Summary: PAK6 targeting to cell–cell contacts is dependent on both a polybasic motif and binding to Cdc42. Disruption of PAK6 targeting to cell–cell contacts inhibits epithelial cell colony escape.

  • Open Access
    CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor cells
    Ying Xu, Tao Wang
    Journal of Cell Science 2016 129: 394-405; doi: 10.1242/jcs.178764

    Summary: CULD, a CUB- and LDLa-domain transmembrane protein that is enriched in photoreceptor cells, is required in endocytic turnover of rhodopsin and TRPL.

  • Open Access
    Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins
    Stanley C. Xie, Con Dogovski, Eric Hanssen, Francis Chiu, Tuo Yang, Maria P. Crespo, Che Stafford, Steven Batinovic, Silvia Teguh, Susan Charman, Nectarios Klonis, Leann Tilley
    Journal of Cell Science 2016 129: 406-416; doi: 10.1242/jcs.178830

    Summary: Down-modulation of the expression of haemoglobin-degrading falcipains in P. falciparum renders early ring stage parasites resistant to artemisinins.

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    Orc5 induces large-scale chromatin decondensation in a GCN5-dependent manner
    Sumanprava Giri, Arindam Chakraborty, Kizhakke M. Sathyan, Kannanganattu V. Prasanth, Supriya G. Prasanth
    Journal of Cell Science 2016 129: 417-429; doi: 10.1242/jcs.178889

    Summary: Human Orc5 associates with H3 histone acetyl transferase GCN5, enhancing the chromatin-opening function of Orc5 during G1 and allows the establishment of preRCs at the origins.

  • You have accessSubscription required
    Rop, the Sec1/Munc18 homolog in Drosophila, is required for furrow ingression and stable cell shape during cytokinesis
    Heather DeBruhl, Roger Albertson, Zachary Swider, William Sullivan
    Journal of Cell Science 2016 129: 430-443; doi: 10.1242/jcs.179200

    Summary: Live-imaging genetic screens revealed that Rop, a homolog of the syntaxin-interacting protein Sec1/Munc18, is required for maintaining contractile ring integrity and cell shape during furrow ingression.

TOOLS AND TECHNIQUES

  • Open Access
    Fast and precise targeting of single tumor cells in vivo by multimodal correlative microscopy
    Matthia A. Karreman, Luc Mercier, Nicole L. Schieber, Gergely Solecki, Guillaume Allio, Frank Winkler, Bernhard Ruthensteiner, Jacky G. Goetz, Yannick Schwab
    Journal of Cell Science 2016 129: 444-456; doi: 10.1242/jcs.181842

    Highlighted Article: We provide here a novel correlative workflow combining intravital microscopy, microCT and 3D electron microscopy to reveal metastatic events in mouse brain and skin tissue at high resolution.

CORRECTION

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    Volume regulation and shape bifurcation in the cell nucleus
    Dong-Hwee Kim, Bo Li, Fangwei Si, Jude M. Phillip, Denis Wirtz, Sean X. Sun
    Journal of Cell Science 2016 129: 457 doi: 10.1242/jcs.185173

ARTICLES OF INTEREST IN OTHER COB JOURNALS

  • From Development

    • You have accessSubscription required
      Two classes of matrix metalloproteinases reciprocally regulate synaptogenesis
      Mary Lynn Dear, Neil Dani, William Parkinson, Scott Zhou, Kendal Broadie
      Journal of Cell Science 2016 129: e1.1 doi: 10.1242/jcs.185363
    • You have accessSubscription required
      Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to promote C. elegans elongation
      Sophie Quintin, Shahoe Wang, Julien Pontabry, Ambre Bender, François Robin, Vincent Hyenne, Frédéric Landmann, Christelle Gally, Karen Oegema, Michel Labouesse
      Journal of Cell Science 2016 129: e1.2 doi: 10.1242/jcs.185371
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    Intercellular and intracellular cilia orientation is coordinated by CELSR1 and CAMSAP3 in oviduct multiciliated cells

    Fumiko Matsukawa Usami, Masaki Arata, Dongbo Shi, Sanae Oka, Yoko Higuchi, Fadel Tissir, Masatoshi Takeichi, Toshihiko Fujimori
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    Cortical recruitment of centralspindlin and RhoA effectors during meiosis I of C. elegans primary spermatocytes

    Xiangchuan Wang, Dandan Zhang, Cunni Zheng, Shian Wu, Michael Glotzer, Yu Chung Tse
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    An endometrial organoid model of Chlamydia-epithelial and immune cell interactions

    Lee Dolat, Raphael H. Valdivia
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    The phosphatidylinositol 3-phosphate binding protein SNX4 controls ATG9A recycling and autophagy

    Anthony Ravussin, Andreas Brech, Sharon A. Tooze, Harald Stenmark
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    Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor

    Sarah O'Keefe, Peristera Roboti, Kwabena B. Duah, Guanghui Zong, Hayden Schneider, Wei Q. Shi, Stephen High
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