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October, 2016; 129 (20)

IN THIS ISSUE

  • You have accessSubscription required
    Interplay of desmin and αB-crystallin in cardioprotection
    Journal of Cell Science 2016 129: e2001
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    Fly cilia do not require the MKS complex
    Journal of Cell Science 2016 129: e2002
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    A link between exocytosis and actin regulators at the leading edge
    Journal of Cell Science 2016 129: e2003
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    Trafficking of transmembrane proteins for autophagy
    Journal of Cell Science 2016 129: e2004
  • You have accessSubscription required
    A close link between lipid droplets and the ER lumen
    Journal of Cell Science 2016 129: e2005
  • You have accessSubscription required
    Sortilin emerges as a receptor for Sonic Hedgehog sorting
    Journal of Cell Science 2016 129: e2006

COMMENTARIES

  • You have accessSubscription required
    Autophagy in adhesion and migration
    Candia M. Kenific, Torsten Wittmann, Jayanta Debnath
    Journal of Cell Science 2016 129: 3685-3693; doi: 10.1242/jcs.188490

    Summary: Discussion of emerging roles for selective autophagy in adhesion and migration through regulation of focal adhesion turnover, cellular tension and integrin trafficking.

  • You have accessSubscription required
    The changing view of eukaryogenesis – fossils, cells, lineages and how they all come together
    Joel B. Dacks, Mark C. Field, Roger Buick, Laura Eme, Simonetta Gribaldo, Andrew J. Roger, Céline Brochier-Armanet, Damien P. Devos
    Journal of Cell Science 2016 129: 3695-3703; doi: 10.1242/jcs.178566

    Summary: Eukaryogenesis, the emergence of eukaryotic cells, represents a pivotal evolutionary event. Advances in paleogeology, phylogenetics, cell biology and microbial diversity provide new insights into aspects of eukaryogenesis.

RESEARCH ARTICLES

  • You have accessSubscription required
    Desmin and αB-crystallin interplay in the maintenance of mitochondrial homeostasis and cardiomyocyte survival
    Antigoni Diokmetzidou, Elisavet Soumaka, Ismini Kloukina, Mary Tsikitis, Manousos Makridakis, Aimilia Varela, Constantinos H. Davos, Spiros Georgopoulos, Vasiliki Anesti, Antonia Vlahou, Yassemi Capetanaki
    Journal of Cell Science 2016 129: 3705-3720; doi: 10.1242/jcs.192203

    Highlighted Article: Both desmin and its partner chaperone αB-crystallin associate with mitochondria–sarcoplasmic-reticulum contact sites (MAMs), stabilizing MICOS super-complexes, and thus contributing to proper mitochondrial cristae structure–function.

  • Open Access
    C. elegans midbodies are released, phagocytosed and undergo LC3-dependent degradation independent of macroautophagy
    Gholamreza Fazeli, Michaela Trinkwalder, Linda Irmisch, Ann Marie Wehman
    Journal of Cell Science 2016 129: 3721-3731; doi: 10.1242/jcs.190223

    Summary: Autophagy proteins are required for the degradation of midbodies. In C. elegans, Atg8/LC3-family proteins act during phagosome maturation rather than during macroautophagy.

  • Open Access
    Drosophila sensory cilia lacking MKS proteins exhibit striking defects in development but only subtle defects in adults
    Metta B. Pratt, Joshua S. Titlow, Ilan Davis, Amy R. Barker, Helen R. Dawe, Jordan W. Raff, Helio Roque
    Journal of Cell Science 2016 129: 3732-3743; doi: 10.1242/jcs.194621

    Highlighted Article: An analysis of Meckel–Gruber syndrome (MKS) fly mutants reveals that cilium structure is perturbed during development, but that cilia are largely structurally and functionally normal by adulthood.

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    Triadin and CLIMP-63 form a link between triads and microtubules in muscle cells
    Alexis Osseni, Muriel Sébastien, Oriana Sarrault, Mathieu Baudet, Yohann Couté, Julien Fauré, Anne Fourest-Lieuvin, Isabelle Marty
    Journal of Cell Science 2016 129: 3744-3755; doi: 10.1242/jcs.188862

    Summary: CLIMP-63 is associated with the Ca2+ release complex of skeletal muscles through its interaction with triadin, and is involved in the shaping of triads and in the guidance of microtubules.

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    Direct interaction between exocyst and Wave complexes promotes cell protrusions and motility
    Marco Biondini, Amel Sadou-Dubourgnoux, Perrine Paul-Gilloteaux, Giulia Zago, Melis D. Arslanhan, François Waharte, Etienne Formstecher, Maud Hertzog, Jinchao Yu, Raphael Guerois, Alexis Gautreau, Giorgio Scita, Jacques Camonis, Maria Carla Parrini
    Journal of Cell Science 2016 129: 3756-3769; doi: 10.1242/jcs.187336

    Highlighted Article: A direct link between exocyst and Wave complexes is revealed, providing new mechanistic insight into the spatio-temporal coordination between membrane trafficking and actin polymerization.

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    Cdc48 and Ubx1 participate in a pathway associated with the inner nuclear membrane that governs Asi1 degradation
    Marina Pantazopoulou, Mirta Boban, Roland Foisner, Per O. Ljungdahl
    Journal of Cell Science 2016 129: 3770-3780; doi: 10.1242/jcs.189332

    Summary: The inner nuclear membrane (INM) E3 ubiquitin ligase component Asi1 is ubiquitylated, removed from the membrane and targeted to nuclear proteasomes through a new INM-associated degradation pathway.

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    Atg9A trafficking through the recycling endosomes is required for autophagosome formation
    Kenta Imai, Feike Hao, Naonobu Fujita, Yasuhiro Tsuji, Yukako Oe, Yasuhiro Araki, Maho Hamasaki, Takeshi Noda, Tamotsu Yoshimori
    Journal of Cell Science 2016 129: 3781-3791; doi: 10.1242/jcs.196196

    Highlighted Article: Atg9A trafficking through the recycling endosome is required for autophagy, and is mediated by TRAPPIII and intrinstic Atg9A-sorting motifs that bind to AP2.

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    Prolyl endopeptidase is involved in the degradation of neural cell adhesion molecules in vitro
    Külli Jaako, Alexander Waniek, Keiti Parik, Linda Klimaviciusa, Anu Aonurm-Helm, Aveli Noortoots, Kaili Anier, Roos Van Elzen, Melanie Gérard, Anne-Marie Lambeir, Steffen Roßner, Markus Morawski, Alexander Zharkovsky
    Journal of Cell Science 2016 129: 3792-3802; doi: 10.1242/jcs.181891

    Summary: NCAM and its polysialylated form (PSA-NCAM) are important regulators of brain plasticity. We demonstrate that prolyl endopeptidase (PREP) is involved in the regulation of NCAM and PSA-NCAM.

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    Mature lipid droplets are accessible to ER luminal proteins
    Shirish Mishra, Rasha Khaddaj, Stéphanie Cottier, Vendula Stradalova, Claire Jacob, Roger Schneiter
    Journal of Cell Science 2016 129: 3803-3815; doi: 10.1242/jcs.189191

    Highlighted Article: Lipid droplets are accessible to ER luminal proteins, suggesting that lipid droplets form a specialized domain within the ER membrane that can be recognized from both the cytosolic and the luminal side.

  • Open Access
    DUX4 induces a transcriptome more characteristic of a less-differentiated cell state and inhibits myogenesis
    Paul Knopp, Yvonne D. Krom, Christopher R. S. Banerji, Maryna Panamarova, Louise A. Moyle, Bianca den Hamer, Silvère M. van der Maarel, Peter S. Zammit
    Journal of Cell Science 2016 129: 3816-3831; doi: 10.1242/jcs.180372

    Summary: DUX4 underlies pathogenesis in facioscapulohumeral muscular dystrophy. DUX4 acts mainly as a transcriptional activator that inhibits myogenesis by orchestrating a gene expression profile representative of a more stem-cell-like state.

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    Sortilin regulates sorting and secretion of Sonic hedgehog
    Charles Campbell, Shawn Beug, Philip E. B. Nickerson, Jimmy Peng, Chantal Mazerolle, Erin A. Bassett, Randy Ringuette, Fadumo A. Jama, Carlos Morales, Annabel Christ, Valerie A. Wallace
    Journal of Cell Science 2016 129: 3832-3844; doi: 10.1242/jcs.183541

    Highlighted Article: We report a new role for sortilin (Sort1) as a negative regulator of Sonic hedgehog trafficking to axons and secretion from cells.

  • Open Access
    The role of ADP-ribosylation in regulating DNA interstrand crosslink repair
    Alasdair R. Gunn, Benito Banos-Pinero, Peggy Paschke, Luis Sanchez-Pulido, Antonio Ariza, Joseph Day, Mehera Emrich, David Leys, Chris P. Ponting, Ivan Ahel, Nicholas D. Lakin
    Journal of Cell Science 2016 129: 3845-3858; doi: 10.1242/jcs.193375

    Summary: Here, we identify a role for post-translational modification ADP-ribosylation in the response to DNA interstrand crosslinks in the model Dictyostelium.

  • Open Access
    Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx
    Bethan S. Kilpatrick, Elizabeth Yates, Christian Grimm, Anthony H. Schapira, Sandip Patel
    Journal of Cell Science 2016 129: 3859-3867; doi: 10.1242/jcs.190322

    Summary: The endolysosomal ion channel TRP mucolipin 1 was thought to mediate local Ca2+ signals. However, as reported here, it can also mediate global elevations in Ca2+.

  • You have accessSubscription required
    Inhibition of cargo export at ER exit sites and the trans-Golgi network by the secretion inhibitor FLI-06
    Yoji Yonemura, Xiaolin Li, Katja Müller, Andreas Krämer, Paul Atigbire, Torben Mentrup, Talitha Feuerhake, Torsten Kroll, Olga Shomron, Richard Nohl, Hans-Dieter Arndt, Christian Hoischen, Peter Hemmerich, Koret Hirschberg, Christoph Kaether
    Journal of Cell Science 2016 129: 3868-3877; doi: 10.1242/jcs.186163

    Summary: The secretion inhibitor FLI-06 inhibits recruitment of cargo into ERES by a mechanism upstream of Sar1 and COPII, and also blocks exit from the trans-Golgi network.

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    Characterization of prion protein function by focal neurite stimulation
    Ladan Amin, Xuan T. A. Nguyen, Irene Giulia Rolle, Elisa D'Este, Gabriele Giachin, Thanh Hoa Tran, Vladka Čurin Šerbec, Dan Cojoc, Giuseppe Legname
    Journal of Cell Science 2016 129: 3878-3891; doi: 10.1242/jcs.183137

    Summary: By using a novel approach to stimulate and guide the growth cones of hippocampal neurons with high spatial and temporal resolution, we reveal a function for the soluble form of PrP to promote fast neurite outgrowth.

  • Open Access
    Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay
    Melissa V. Gammons, Trevor J. Rutherford, Zachary Steinhart, Stephane Angers, Mariann Bienz
    Journal of Cell Science 2016 129: 3892-3902; doi: 10.1242/jcs.195685

    Summary: A physiological complementation assay in Dishevelled null-mutant human cells establishes an essential function of the DEP domain of Dishevelled in its binding to Frizzled for signal transduction to β-catenin.

  • Open Access
    Mutant IP3 receptors attenuate store-operated Ca2+ entry by destabilizing STIM–Orai interactions in Drosophila neurons
    Sumita Chakraborty, Bipan K. Deb, Tetyana Chorna, Vera Konieczny, Colin W. Taylor, Gaiti Hasan
    Journal of Cell Science 2016 129: 3903-3910; doi: 10.1242/jcs.191585

    Summary: In Drosophila neurons, mutant IP3 receptors disrupt store-operated Ca2+ entry by destabilizing interaction of STIM with the Ca2+ channel, Orai. The interactions could coordinate store emptying with Ca2+ entry.

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    Neuropilin-1 modulates interferon-γ-stimulated signaling in brain microvascular endothelial cells
    Ying Wang, Ying Cao, Ashutosh K. Mangalam, Yong Guo, Reghann G. LaFrance-Corey, Jeffrey D. Gamez, Pascal Aliihnui Atanga, Benjamin D. Clarkson, Yuebo Zhang, Enfeng Wang, Ramcharan Singh Angom, Kirthica Dutta, Baoan Ji, Istvan Pirko, Claudia F. Lucchinetti, Charles L. Howe, Debabrata Mukhopadhyay
    Journal of Cell Science 2016 129: 3911-3921; doi: 10.1242/jcs.190702

    Summary: This is the first study to define the role of neuropilin-1, a co-receptor of several structurally distinct cytokines, in the IFNγ-induced inflammatory response of endothelial cells in neuroinflammatory diseases.

  • Open Access
    A ternary complex comprising transportin1, Rab8 and the ciliary targeting signal directs proteins to ciliary membranes
    Viswanadh Madugula, Lei Lu
    Journal of Cell Science 2016 129: 3922-3934; doi: 10.1242/jcs.194019

    Summary: Transportin1 and Rab8 can simultaneously bind to the ciliary targeting signal in a guanine-nucleotide-dependent manner. The resulting ternary complex can target a membrane protein to cilia.

  • You have accessSubscription required
    Plant mitochondria contain the protein translocase subunits TatB and TatC
    Chris Carrie, Stefan Weißenberger, Jürgen Soll
    Journal of Cell Science 2016 129: 3935-3947; doi: 10.1242/jcs.190975

    Summary: This paper provides evidence that Arabidopsis thaliana mitochondria contain two subunits of a twin arginine translocation (Tat) pathway, indicating the presence of an active Tat pathway in plants.

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    Exosomes bind to autotaxin and act as a physiological delivery mechanism to stimulate LPA receptor signalling in cells
    Susanna A. Jethwa, Emma J. Leah, Qifeng Zhang, Nicholas A. Bright, David Oxley, Martin D. Bootman, Simon A. Rudge, Michael J. O. Wakelam
    Journal of Cell Science 2016 129: 3948-3957; doi: 10.1242/jcs.184424

    Summary: Autotaxin, a secreted enzyme that generates lysophosphatidic acid (LPA), binds to exosomes and is thereby targeted to cells in order to deliver LPA and activate cell surface receptors.

ARTICLES OF INTEREST IN OUR OTHER JOURNALS

  • From Development

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      Vinculin b deficiency causes epicardial hyperplasia and coronary vessel disorganization in zebrafish
      Feng Cheng, Liyun Miao, Qing Wu, Xia Gong, Jingwei Xiong, Jian Zhang
      Journal of Cell Science 2016 129: e1.1 doi: 10.1242/jcs.197996
    • You have accessSubscription required
      Microtubule-severing activity of AAA+ ATPase Katanin is essential for female meiotic spindle assembly
      Nicolas Joly, Lisa Martino, Emmanuelle Gigant, Julien Dumont, Lionel Pintard
      Journal of Cell Science 2016 129: e1.2 doi: 10.1242/jcs.198002
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    Intercellular and intracellular cilia orientation is coordinated by CELSR1 and CAMSAP3 in oviduct multiciliated cells

    Fumiko Matsukawa Usami, Masaki Arata, Dongbo Shi, Sanae Oka, Yoko Higuchi, Fadel Tissir, Masatoshi Takeichi, Toshihiko Fujimori
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    Cortical recruitment of centralspindlin and RhoA effectors during meiosis I of C. elegans primary spermatocytes

    Xiangchuan Wang, Dandan Zhang, Cunni Zheng, Shian Wu, Michael Glotzer, Yu Chung Tse
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    An endometrial organoid model of Chlamydia-epithelial and immune cell interactions

    Lee Dolat, Raphael H. Valdivia
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    The phosphatidylinositol 3-phosphate binding protein SNX4 controls ATG9A recycling and autophagy

    Anthony Ravussin, Andreas Brech, Sharon A. Tooze, Harald Stenmark
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    Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor

    Sarah O'Keefe, Peristera Roboti, Kwabena B. Duah, Guanghui Zong, Hayden Schneider, Wei Q. Shi, Stephen High
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