IN THIS ISSUE
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
- The integrin adhesome network at a glance
Summary: We have generated a new depiction of the integrin adhesome network that integrates experimentally derived IAC proteomes with the literature-curated adhesome to bridge the knowledge gap between these two resources.
COMMENTARY
- Emerging biological roles of Cl− intracellular channel proteins
Summary: Emerging evidence points to a role of CLIC proteins in actin dynamics and membrane trafficking.
RESEARCH ARTICLES
- Ligand-induced growth and compaction of CD36 nanoclusters enriched in Fyn induces Fyn signaling
Highlighted Article: The receptor CD36 exists in nanoclusters enriched with the downstream effector Fyn when unligated; multivalent ligands enhance the clusters and activate Fyn, bypassing de novo recruitment of Fyn to the clusters.
- Phosphorylation of STAT2 on serine-734 negatively regulates the IFN-α-induced antiviral response
Summary: Phosphorylation of STAT2 at S724 selectively regulates the antiviral, but not the anti-proliferative, effects of type I interferons (IFNs) by limiting the expression of a select subset of IFN-stimulated genes.
- ELYS regulates the localization of LBR by modulating its phosphorylation state
Highlighted Article: The nuclear envelope localization of LBR is regulated through a phosphorylation network governed by ELYS, and defects in this phosphorylation network induce the aberrant phosphorylation and mislocalization of LBR.
- HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia
Summary: Phosphorylation of hypoxia inducible factor 2α mediated by casein kinase 1δ increases erythropoietin production by impairing a CRM1-dependent nuclear export mechanism in liver cancer cells.
- Nuclear alignment in myotubes requires centrosome proteins recruited by nesprin-1
Highlighted Article: Nuclear positioning in myotubes requires centrosome proteins recruited early in differentiation to the nuclear envelope in a nesprin-1-dependent manner. These contribute to the recruitment of microtubule motor proteins.
- Acid sphingomyelinase is required for cell surface presentation of Met receptor tyrosine kinase in cancer cells
Summary: Acid sphingomyelinase (ASM) regulates the cell surface levels of Met receptor tyrosine kinase through selective regulation of the exit of Met from the Golgi.
- A new isoform of Drosophila non-muscle Tropomyosin 1 interacts with Kinesin-1 and functions in oskar mRNA localization
Highlighted Article: A previously uncharacterized isoform of Tropomyosin, referred to as Tm1C, directly interacts with Kinesin heavy chain and functions along with this microtubule motor to localize oskar mRNA in Drosophila oocytes.
- The C-terminal domain of Kv1.3 regulates functional interactions with the KCNE4 subunit
Summary: Kv1.3 and KCNE4 form functional channels in leukocytes. KCNE4 associates with the C-terminal domain of Kv1.3 providing two independent and additive mechanisms for the intracellular retention of the complex.
- Control of apico–basal epithelial polarity by the microtubule minus-end-binding protein CAMSAP3 and spectraplakin ACF7
Highlighted Article: The spectraplakin ACF7 and microtubule minus-end-stabilizing protein CAMSAP3 cooperate in organizing non-centrosomal microtubule arrays in intestinal epithelial cells.
- Atg20- and Atg24-family proteins promote organelle autophagy in fission yeast
Summary: Fission yeast Atg20- and Atg24-family proteins promote starvation-induced autophagy of ER and mitochondria, and we propose that their function is to ensure that autophagosomes are of a sufficient size.
- HMGB2 regulates satellite-cell-mediated skeletal muscle regeneration through IGF2BP2
Summary: HMGB2 promotes myoblast proliferation and muscle regeneration through IGF2BP2, which regulates the protein production of cyclin A2 and Myf5.
ARTICLES OF INTEREST IN OUR OTHER JOURNALS
From Development
This issue
JUMP TO
Other journals from The Company of Biologists
JCS and COVID-19
We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.
Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.
Introducing FocalPlane – where biology meets microscopy
JCS is excited to announce to the development of a brand new microscopy community site. Launching in summer 2020, the site will provide a trusted, curated and centralised forum to connect people, resources and information within the microscopy community. Follow us on Twitter @focalplane_js or sign up to for news alerts for the latest developments.
Behind the scenes of a JCS Meeting
See for yourself what JCS Meetings are really like with this video from the 2019 Meeting, held in Lisbon, Portugal. Scientists studying the interface between organelles and the cytoskeleton gathered to discuss cutting-edge research and new techniques in the field. Find out more about Meetings run by The Company of Biologists.
Meet the preLighters – an interview with Tim
Tim Fessenden is a postdoc in the Spranger Lab at the Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology (MIT), Cambridge, MA, USA. In an interview, he talks about his immunology research, science communication and preprints.
The Biology Open transfer option
JCS authors have the option to transfer their submissions to our sister journal Biology Open with just one click. An online Open Access journal, BiO also welcomes direct submissions and focuses on the swift publication of high-quality, sound research. Recent cell biology highlights in BiO include work from Saverio Brogna’s lab describing their novel method for visualising ribosomes. Find out more about how to transfer.
Interviews – Nadine, Roopali and Alexander
In this issue, first authors Nadine Sen Nkwe, Roopali Pradhan and Alexander Kiepas each talk about their JCS papers, those ‘eureka’ moments and their role models in science. Catch up with the full archive of interviews with our first authors.
Publishing peer review reports
To continue working towards transparency around the editorial process, JCS now publishes a ‘Peer review history file’ alongside published papers. Read more about the policy and see the reports for yourself in one of the first papers to take advantage of this initiative (under the ‘Info & metrics’ tab).